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Q13069

- GAGE5_HUMAN

UniProt

Q13069 - GAGE5_HUMAN

Protein

G antigen 5

Gene

GAGE5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 5
    Short name:
    GAGE-5
    Alternative name(s):
    Cancer/testis antigen 4.5
    Short name:
    CT4.5
    Gene namesi
    Name:GAGE5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4102. GAGE5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28517.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 117117G antigen 5PRO_0000148343Add
    BLAST

    PTM databases

    PhosphoSiteiQ13069.

    Expressioni

    Tissue specificityi

    Expressed in a variety of tumor tissues but not in normal tissues, except testis.

    Gene expression databases

    GenevestigatoriQ13069.

    Organism-specific databases

    HPAiHPA043232.

    Interactioni

    Protein-protein interaction databases

    BioGridi108850. 2 interactions.
    IntActiQ13069. 2 interactions.
    MINTiMINT-1453280.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    HOVERGENiHBG056227.
    InParanoidiQ13069.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13069-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR    50
    QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP 100
    NPEEVKTPEE GEKQSQC 117
    Length:117
    Mass (Da):12,924
    Last modified:November 1, 1996 - v1
    Checksum:i234A865E2ECDDD06
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231V → M in CAG47032. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19146 mRNA. Translation: AAA82748.1.
    CR542236 mRNA. Translation: CAG47032.1.
    BC024914 mRNA. Translation: AAH24914.1.
    RefSeqiNP_001465.1. NM_001474.1.
    NP_001466.1. NM_001475.1.
    UniGeneiHs.460641.
    Hs.695912.
    Hs.722100.

    Genome annotation databases

    GeneIDi2576.
    2577.
    KEGGihsa:2576.
    hsa:2577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19146 mRNA. Translation: AAA82748.1 .
    CR542236 mRNA. Translation: CAG47032.1 .
    BC024914 mRNA. Translation: AAH24914.1 .
    RefSeqi NP_001465.1. NM_001474.1.
    NP_001466.1. NM_001475.1.
    UniGenei Hs.460641.
    Hs.695912.
    Hs.722100.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108850. 2 interactions.
    IntActi Q13069. 2 interactions.
    MINTi MINT-1453280.

    PTM databases

    PhosphoSitei Q13069.

    Protocols and materials databases

    DNASUi 2576.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2576.
    2577.
    KEGGi hsa:2576.
    hsa:2577.

    Organism-specific databases

    CTDi 2576.
    2577.
    GeneCardsi GC0XU990068.
    HGNCi HGNC:4102. GAGE5.
    HPAi HPA043232.
    MIMi 300598. gene.
    neXtProti NX_Q13069.
    PharmGKBi PA28517.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG056227.
    InParanoidi Q13069.

    Miscellaneous databases

    NextBioi 10185.
    PROi Q13069.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q13069.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
      van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
      J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Melanoma.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
      De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
      Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
    5. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGAGE5_HUMAN
    AccessioniPrimary (citable) accession number: Q13069
    Secondary accession number(s): Q6FG72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3