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Q13069 (GAGE5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G antigen 5

Short name=GAGE-5
Alternative name(s):
Cancer/testis antigen 4.5
Short name=CT4.5
Gene names
Name:GAGE5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Sequence similarities

Belongs to the GAGE family.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.5 presented a new GAGE gene nomenclature based on the identified genes and their products.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 117117G antigen 5
PRO_0000148343

Experimental info

Sequence conflict231V → M in CAG47032. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q13069 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 234A865E2ECDDD06

FASTA11712,924
        10         20         30         40         50         60 
MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE 

        70         80         90        100        110 
DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC 

« Hide

References

« Hide 'large scale' references
[1]"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Melanoma.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[4]"Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
[5]"An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
Gjerstorff M.F., Ditzel H.J.
Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GAGE FAMILY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19146 mRNA. Translation: AAA82748.1.
CR542236 mRNA. Translation: CAG47032.1.
BC024914 mRNA. Translation: AAH24914.1.
RefSeqNP_001465.1. NM_001474.1.
NP_001466.1. NM_001475.1.
UniGeneHs.460641.
Hs.695912.
Hs.722100.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108850. 2 interactions.
IntActQ13069. 2 interactions.
MINTMINT-1453280.

PTM databases

PhosphoSiteQ13069.

Protocols and materials databases

DNASU2576.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2576.
2577.
KEGGhsa:2576.
hsa:2577.

Organism-specific databases

CTD2576.
2577.
GeneCardsGC0XU990068.
HGNCHGNC:4102. GAGE5.
HPAHPA043232.
MIM300598. gene.
neXtProtNX_Q13069.
PharmGKBPA28517.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG056227.
InParanoidQ13069.

Gene expression databases

GenevestigatorQ13069.

Family and domain databases

InterProIPR008625. GAGE.
[Graphical view]
PfamPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio10185.
PROQ13069.
SOURCESearch...

Entry information

Entry nameGAGE5_HUMAN
AccessionPrimary (citable) accession number: Q13069
Secondary accession number(s): Q6FG72
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM