Q13069 (GAGE5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G antigen 5
Short name=GAGE-5

Alternative name(s):
Cancer/testis antigen 4.5
Short name=CT4.5

Gene names

Name:

GAGE5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in a variety of tumor tissues but not in normal tissues, except testis.
Miscellaneous	This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.
Sequence similarities	Belongs to the GAGE family.
Caution	The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.5 presented a new GAGE gene nomenclature based on the identified genes and their products.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	G antigen 5		PRO_0000148343
Experimental info
	Sequence conflict	23	1	V → M in CAG47032. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q13069 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 234A865E2ECDDD06	FASTA	117	12,924
	10 20 30 40 50 60 MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE 70 80 90 100 110 DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma." van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T. J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Melanoma.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[4]	"Characterization of the GAGE genes that are expressed in various human cancers and in normal testis." De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P. Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
[5]	"An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members." Gjerstorff M.F., Ditzel H.J. Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GAGE FAMILY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19146 mRNA. Translation: AAA82748.1. CR542236 mRNA. Translation: CAG47032.1. BC024914 mRNA. Translation: AAH24914.1.
IPI	IPI00011531.
RefSeq	NP_001465.1. NM_001474.1. NP_001466.1. NM_001475.1.
UniGene	Hs.460641. Hs.722100.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13069. 1 interaction.
MINT	MINT-1453280.
PTM databases
PhosphoSite	Q13069.
Polymorphism databases
DMDM	3023875.
Protocols and materials databases
DNASU	2576.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2576. 2577.
KEGG	hsa:2576. hsa:2577.
Organism-specific databases
CTD	2576. 2577.
GeneCards	GC0XU990068.
HGNC	HGNC:4102. GAGE5.
HPA	HPA043232.
MIM	300598. gene.
neXtProt	NX_Q13069.
PharmGKB	PA28517.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG056227.
InParanoid	Q13069.
Gene expression databases
Genevestigator	Q13069.
GermOnline	ENSG00000068990. Homo sapiens. ENSG00000198716. Homo sapiens. ENSG00000205777. Homo sapiens.
Family and domain databases
InterPro	IPR008625. GAGE. [Graphical view]
Pfam	PF05831. GAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	10185.
SOURCE	Search...

Entry information

Entry name

GAGE5_HUMAN

Accession

Primary (citable) accession number: Q13069
Secondary accession number(s): Q6FG72

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.