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Protein

G antigen 5

Gene

GAGE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 5
Short name:
GAGE-5
Alternative name(s):
Cancer/testis antigen 4.5
Short name:
CT4.5
Gene namesi
Name:GAGE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4102. GAGE5.

Pathology & Biotechi

Organism-specific databases

DisGeNETi2543.
2576.
2577.
PharmGKBiPA28517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483431 – 117G antigen 5Add BLAST117

Proteomic databases

MaxQBiQ13069.
PaxDbiQ13069.
PRIDEiQ13069.
TopDownProteomicsiQ13069.

PTM databases

iPTMnetiQ13069.
PhosphoSitePlusiQ13069.

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Organism-specific databases

HPAiHPA043232.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FLJ13057Q53SE73EBI-745702,EBI-10172181
GMCL1Q96IK53EBI-745702,EBI-2548508
GMCL1P1Q8NEA96EBI-745702,EBI-745707
TERF2IPQ9NYB02EBI-745702,EBI-750109

Protein-protein interaction databases

BioGridi108850. 3 interactors.
IntActiQ13069. 4 interactors.
MINTiMINT-1453280.

Structurei

3D structure databases

ProteinModelPortaliQ13069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOVERGENiHBG056227.
InParanoidiQ13069.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
SMARTiSM01379. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,924
Last modified:November 1, 1996 - v1
Checksum:i234A865E2ECDDD06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23V → M in CAG47032 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19146 mRNA. Translation: AAA82748.1.
CR542236 mRNA. Translation: CAG47032.1.
BC024914 mRNA. Translation: AAH24914.1.
RefSeqiNP_001465.1. NM_001474.1.
NP_001466.1. NM_001475.1.
UniGeneiHs.460641.
Hs.695912.
Hs.722100.

Genome annotation databases

GeneIDi2576.
2577.
KEGGihsa:2576.
hsa:2577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19146 mRNA. Translation: AAA82748.1.
CR542236 mRNA. Translation: CAG47032.1.
BC024914 mRNA. Translation: AAH24914.1.
RefSeqiNP_001465.1. NM_001474.1.
NP_001466.1. NM_001475.1.
UniGeneiHs.460641.
Hs.695912.
Hs.722100.

3D structure databases

ProteinModelPortaliQ13069.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108850. 3 interactors.
IntActiQ13069. 4 interactors.
MINTiMINT-1453280.

PTM databases

iPTMnetiQ13069.
PhosphoSitePlusiQ13069.

Proteomic databases

MaxQBiQ13069.
PaxDbiQ13069.
PRIDEiQ13069.
TopDownProteomicsiQ13069.

Protocols and materials databases

DNASUi2576.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2576.
2577.
KEGGihsa:2576.
hsa:2577.

Organism-specific databases

CTDi2576.
2577.
DisGeNETi2543.
2576.
2577.
GeneCardsiGAGE5.
HGNCiHGNC:4102. GAGE5.
HPAiHPA043232.
MIMi300598. gene.
neXtProtiNX_Q13069.
PharmGKBiPA28517.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOVERGENiHBG056227.
InParanoidiQ13069.

Miscellaneous databases

PROiQ13069.
SOURCEiSearch...

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
SMARTiSM01379. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAGE5_HUMAN
AccessioniPrimary (citable) accession number: Q13069
Secondary accession number(s): Q6FG72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.