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Q13069

- GAGE5_HUMAN

UniProt

Q13069 - GAGE5_HUMAN

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Protein

G antigen 5

Gene

GAGE5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 5
Short name:
GAGE-5
Alternative name(s):
Cancer/testis antigen 4.5
Short name:
CT4.5
Gene namesi
Name:GAGE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4102. GAGE5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117G antigen 5PRO_0000148343Add
BLAST

PTM databases

PhosphoSiteiQ13069.

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Gene expression databases

GenevestigatoriQ13069.

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

BioGridi108850. 2 interactions.
IntActiQ13069. 2 interactions.
MINTiMINT-1453280.

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

HOVERGENiHBG056227.
InParanoidiQ13069.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13069-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,924
Last modified:November 1, 1996 - v1
Checksum:i234A865E2ECDDD06
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231V → M in CAG47032. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19146 mRNA. Translation: AAA82748.1.
CR542236 mRNA. Translation: CAG47032.1.
BC024914 mRNA. Translation: AAH24914.1.
RefSeqiNP_001465.1. NM_001474.1.
NP_001466.1. NM_001475.1.
UniGeneiHs.460641.
Hs.695912.
Hs.722100.

Genome annotation databases

GeneIDi2576.
2577.
KEGGihsa:2576.
hsa:2577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19146 mRNA. Translation: AAA82748.1 .
CR542236 mRNA. Translation: CAG47032.1 .
BC024914 mRNA. Translation: AAH24914.1 .
RefSeqi NP_001465.1. NM_001474.1.
NP_001466.1. NM_001475.1.
UniGenei Hs.460641.
Hs.695912.
Hs.722100.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108850. 2 interactions.
IntActi Q13069. 2 interactions.
MINTi MINT-1453280.

PTM databases

PhosphoSitei Q13069.

Protocols and materials databases

DNASUi 2576.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2576.
2577.
KEGGi hsa:2576.
hsa:2577.

Organism-specific databases

CTDi 2576.
2577.
GeneCardsi GC0XU990068.
HGNCi HGNC:4102. GAGE5.
HPAi HPA043232.
MIMi 300598. gene.
neXtProti NX_Q13069.
PharmGKBi PA28517.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG056227.
InParanoidi Q13069.

Miscellaneous databases

NextBioi 10185.
PROi Q13069.
SOURCEi Search...

Gene expression databases

Genevestigatori Q13069.

Family and domain databases

InterProi IPR008625. GAGE.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
    van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
    J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Melanoma.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
    De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
    Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
  5. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGAGE5_HUMAN
AccessioniPrimary (citable) accession number: Q13069
Secondary accession number(s): Q6FG72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3