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Protein

G antigen 5

Gene

GAGE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 5
Short name:
GAGE-5
Alternative name(s):
Cancer/testis antigen 4.5
Short name:
CT4.5
Gene namesi
Name:GAGE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4102 GAGE5
MIMi300598 gene
neXtProtiNX_Q13069

Pathology & Biotechi

Organism-specific databases

DisGeNETi2543
2576
2577
PharmGKBiPA28517

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483431 – 117G antigen 5Add BLAST117

Proteomic databases

MaxQBiQ13069
PeptideAtlasiQ13069
PRIDEiQ13069
TopDownProteomicsiQ13069

PTM databases

iPTMnetiQ13069
PhosphoSitePlusiQ13069

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Organism-specific databases

HPAiHPA043232

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108850, 3 interactors
IntActiQ13069, 4 interactors
MINTiQ13069

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
HOVERGENiHBG056227
InParanoidiQ13069

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q13069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,924
Last modified:November 1, 1996 - v1
Checksum:i234A865E2ECDDD06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23V → M in CAG47032 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19146 mRNA Translation: AAA82748.1
CR542236 mRNA Translation: CAG47032.1
BC024914 mRNA Translation: AAH24914.1
RefSeqiNP_001465.1, NM_001474.1
NP_001466.1, NM_001475.1
UniGeneiHs.460641
Hs.695912
Hs.722100

Genome annotation databases

GeneIDi2576
2577
KEGGihsa:2576
hsa:2577

Similar proteinsi

Entry informationi

Entry nameiGAGE5_HUMAN
AccessioniPrimary (citable) accession number: Q13069
Secondary accession number(s): Q6FG72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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