Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G antigen 3

Gene

GAGE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 3
Short name:
GAGE-3
Alternative name(s):
Cancer/testis antigen 4.3
Short name:
CT4.3
Gene namesi
Name:GAGE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4100. GAGE3.

Pathology & Biotechi

Organism-specific databases

DisGeNETi2575.

Polymorphism and mutation databases

DMDMi3023873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483411 – 118G antigen 3Add BLAST118

Proteomic databases

MaxQBiQ13067.
PaxDbiQ13067.
PeptideAtlasiQ13067.
PRIDEiQ13067.
TopDownProteomicsiQ13067.

PTM databases

iPTMnetiQ13067.
PhosphoSitePlusiQ13067.

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Organism-specific databases

HPAiHPA043232.

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ13067.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSRGKSTY YWPRPRRYVQ PPEVIGPMRP EQFSDEVEPA TPEEGEPATQ
60 70 80 90 100
RQDPAAAQEG EDEGASAGQG PKPEADSQEQ GHPQTGCECE DGPDGQEMDP
110
PNPEEVKTPE EGEKQSQC
Length:118
Mass (Da):12,937
Last modified:November 1, 1996 - v1
Checksum:iD97EEBB19E735103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19144 mRNA. Translation: AAA82746.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19144 mRNA. Translation: AAA82746.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ13067.
PhosphoSitePlusiQ13067.

Polymorphism and mutation databases

DMDMi3023873.

Proteomic databases

MaxQBiQ13067.
PaxDbiQ13067.
PeptideAtlasiQ13067.
PRIDEiQ13067.
TopDownProteomicsiQ13067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi2575.
GeneCardsiGAGE3.
HGNCiHGNC:4100. GAGE3.
HPAiHPA043232.
MIMi300596. gene.
neXtProtiNX_Q13067.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ13067.

Miscellaneous databases

PROiPR:Q13067.
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGAGE3_HUMAN
AccessioniPrimary (citable) accession number: Q13067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 12, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.