Q13067 (GAGE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G antigen 3
Short name=GAGE-3

Alternative name(s):
Cancer/testis antigen 4.3
Short name=CT4.3

Gene names

Name:

GAGE3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in a variety of tumor tissues but not in normal tissues, except testis.
Miscellaneous	This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.
Sequence similarities	Belongs to the GAGE family.
Caution	The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.3 presented a new GAGE gene nomenclature based on the identified genes and their products.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	G antigen 3		PRO_0000148341

Sequences

	Sequence		Length	Mass (Da)
	Q13067 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D97EEBB19E735103	FASTA	118	12,937
	10 20 30 40 50 60 MNLSRGKSTY YWPRPRRYVQ PPEVIGPMRP EQFSDEVEPA TPEEGEPATQ RQDPAAAQEG 70 80 90 100 110 EDEGASAGQG PKPEADSQEQ GHPQTGCECE DGPDGQEMDP PNPEEVKTPE EGEKQSQC

References

[1]	"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma." van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T. J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Melanoma.
[2]	"Characterization of the GAGE genes that are expressed in various human cancers and in normal testis." De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P. Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
[3]	"An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members." Gjerstorff M.F., Ditzel H.J. Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GAGE FAMILY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19144 mRNA. Translation: AAA82746.1.
IPI	IPI00011529.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q13067.
Polymorphism databases
DMDM	3023873.
Proteomic databases
PaxDb	Q13067.
PRIDE	Q13067.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC0XU990066.
HGNC	HGNC:4100. GAGE3.
HPA	HPA043232.
MIM	300596. gene.
neXtProt	NX_Q13067.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293879.
HOGENOM	HOG000237345.
HOVERGEN	HBG056227.
InParanoid	Q13067.
OrthoDB	EOG4C5CM1.
Gene expression databases
Genevestigator	Q13067.
GermOnline	ENSG00000068990. Homo sapiens. ENSG00000198716. Homo sapiens. ENSG00000205777. Homo sapiens.
Family and domain databases
InterPro	IPR008625. GAGE. [Graphical view]
Pfam	PF05831. GAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

GAGE3_HUMAN

Accession

Primary (citable) accession number: Q13067

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.