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Q13067 (GAGE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G antigen 3

Short name=GAGE-3
Alternative name(s):
Cancer/testis antigen 4.3
Short name=CT4.3
Gene names
Name:GAGE3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length118 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Sequence similarities

Belongs to the GAGE family.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.3 presented a new GAGE gene nomenclature based on the identified genes and their products.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 118118G antigen 3
PRO_0000148341

Sequences

Sequence LengthMass (Da)Tools
Q13067 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D97EEBB19E735103

FASTA11812,937
        10         20         30         40         50         60 
MNLSRGKSTY YWPRPRRYVQ PPEVIGPMRP EQFSDEVEPA TPEEGEPATQ RQDPAAAQEG 

        70         80         90        100        110 
EDEGASAGQG PKPEADSQEQ GHPQTGCECE DGPDGQEMDP PNPEEVKTPE EGEKQSQC 

« Hide

References

[1]"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Melanoma.
[2]"Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
[3]"An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
Gjerstorff M.F., Ditzel H.J.
Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GAGE FAMILY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19144 mRNA. Translation: AAA82746.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ13067.

Polymorphism databases

DMDM3023873.

Proteomic databases

PaxDbQ13067.
PRIDEQ13067.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC0XU990066.
HGNCHGNC:4100. GAGE3.
HPAHPA043232.
MIM300596. gene.
neXtProtNX_Q13067.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293879.
HOGENOMHOG000237345.
HOVERGENHBG056227.
InParanoidQ13067.

Gene expression databases

GenevestigatorQ13067.

Family and domain databases

InterProIPR008625. GAGE.
[Graphical view]
PfamPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ13067.
SOURCESearch...

Entry information

Entry nameGAGE3_HUMAN
AccessionPrimary (citable) accession number: Q13067
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 22, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM