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Protein

G antigen 3

Gene

GAGE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 3
Short name:
GAGE-3
Alternative name(s):
Cancer/testis antigen 4.3
Short name:
CT4.3
Gene namesi
Name:GAGE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4100. GAGE3.

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi3023873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118G antigen 3PRO_0000148341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13067.
PaxDbiQ13067.
PRIDEiQ13067.

PTM databases

PhosphoSiteiQ13067.

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Gene expression databases

GenevestigatoriQ13067.

Organism-specific databases

HPAiHPA043232.

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG293879.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ13067.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSRGKSTY YWPRPRRYVQ PPEVIGPMRP EQFSDEVEPA TPEEGEPATQ
60 70 80 90 100
RQDPAAAQEG EDEGASAGQG PKPEADSQEQ GHPQTGCECE DGPDGQEMDP
110
PNPEEVKTPE EGEKQSQC
Length:118
Mass (Da):12,937
Last modified:November 1, 1996 - v1
Checksum:iD97EEBB19E735103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19144 mRNA. Translation: AAA82746.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19144 mRNA. Translation: AAA82746.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ13067.

Polymorphism and mutation databases

DMDMi3023873.

Proteomic databases

MaxQBiQ13067.
PaxDbiQ13067.
PRIDEiQ13067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC0XU990066.
HGNCiHGNC:4100. GAGE3.
HPAiHPA043232.
MIMi300596. gene.
neXtProtiNX_Q13067.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG293879.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ13067.

Miscellaneous databases

PROiQ13067.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ13067.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
    van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
    J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Melanoma.
  2. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
    De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
    Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
  3. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGAGE3_HUMAN
AccessioniPrimary (citable) accession number: Q13067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.