ID   GAG2B_HUMAN             Reviewed;         116 AA.
AC   Q13066; C9K0W9; Q4V322;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   08-NOV-2023, entry version 154.
DE   RecName: Full=G antigen 2B/2C;
DE            Short=GAGE-2B;
DE            Short=GAGE-2C;
DE   AltName: Full=Cancer/testis antigen 4.2;
DE            Short=CT4.2;
DE   AltName: Full=G antigen 2C;
GN   Name=GAGE2B; Synonyms=GAGE2;
GN   and
GN   Name=GAGE2C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Melanoma;
RX   PubMed=7544395; DOI=10.1084/jem.182.3.689;
RA   van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.;
RT   "A new family of genes coding for an antigen recognized by autologous
RT   cytolytic T lymphocytes on a human melanoma.";
RL   J. Exp. Med. 182:689-698(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- FUNCTION: Antigen, recognized on melanoma by autologous cytolytic T-
CC       lymphocytes.
CC   -!- INTERACTION:
CC       Q13066; Q96IK5: GMCL1; NbExp=6; IntAct=EBI-12329121, EBI-2548508;
CC       Q13066; Q14749: GNMT; NbExp=3; IntAct=EBI-12329121, EBI-744239;
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but not in
CC       normal tissues, except testis. {ECO:0000269|PubMed:7544395}.
CC   -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC       clustered repeats. They have a high degree of predicted sequence
CC       identity, but differ by scattered single nucleotide substitution. Their
CC       sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY
CC       which is recognized by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
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DR   EMBL; U19143; AAA82745.1; -; mRNA.
DR   EMBL; BX649339; CAI95424.1; -; Genomic_DNA.
DR   EMBL; BX649339; CAI95425.1; -; Genomic_DNA.
DR   EMBL; BC069309; AAH69309.1; -; mRNA.
DR   EMBL; BC069558; AAH69558.1; -; mRNA.
DR   EMBL; BC113926; AAI13927.1; -; mRNA.
DR   RefSeq; NP_001091881.1; NM_001098411.3.
DR   RefSeq; NP_001463.1; NM_001472.2.
DR   AlphaFoldDB; Q13066; -.
DR   BioGRID; 108847; 3.
DR   BioGRID; 570105; 1.
DR   IntAct; Q13066; 2.
DR   iPTMnet; Q13066; -.
DR   PhosphoSitePlus; Q13066; -.
DR   BioMuta; HGNC:31957; -.
DR   DMDM; 3023872; -.
DR   jPOST; Q13066; -.
DR   MassIVE; Q13066; -.
DR   MaxQB; Q13066; -.
DR   PeptideAtlas; Q13066; -.
DR   Pumba; Q13066; -.
DR   TopDownProteomics; Q13066; -.
DR   DNASU; 2574; -.
DR   GeneID; 2574; -.
DR   GeneID; 645037; -.
DR   KEGG; hsa:2574; -.
DR   KEGG; hsa:645037; -.
DR   AGR; HGNC:31957; -.
DR   AGR; HGNC:31958; -.
DR   CTD; 2574; -.
DR   CTD; 645037; -.
DR   DisGeNET; 2574; -.
DR   DisGeNET; 645037; -.
DR   GeneCards; GAGE2B; -.
DR   GeneCards; GAGE2C; -.
DR   HGNC; HGNC:31957; GAGE2B.
DR   HGNC; HGNC:31958; GAGE2C.
DR   MIM; 300595; gene.
DR   MIM; 300726; gene.
DR   neXtProt; NX_Q13066; -.
DR   PharmGKB; PA162389260; -.
DR   InParanoid; Q13066; -.
DR   PhylomeDB; Q13066; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; Q13066; -.
DR   SignaLink; Q13066; -.
DR   BioGRID-ORCS; 2574; 1 hit in 39 CRISPR screens.
DR   BioGRID-ORCS; 645037; 6 hits in 117 CRISPR screens.
DR   Pharos; Q13066; Tdark.
DR   PRO; PR:Q13066; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q13066; Protein.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047:SF30; G ANTIGEN 1-RELATED; 1.
DR   PANTHER; PTHR14047; P ANTIGEN FAMILY MEMBER 5-RELATED; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..116
FT                   /note="G antigen 2B/2C"
FT                   /id="PRO_0000148340"
FT   REGION          1..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   116 AA;  12786 MW;  DD305D5CA29AF19A CRC64;
     MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED
     EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQC
//