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Q13066

- GAG2B_HUMAN

UniProt

Q13066 - GAG2B_HUMAN

Protein

G antigen 2B/2C

Gene

GAGE2B

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 2B/2C
    Short name:
    GAGE-2B
    Short name:
    GAGE-2C
    Alternative name(s):
    Cancer/testis antigen 4.2
    Short name:
    CT4.2
    G antigen 2C
    Gene namesi
    Name:GAGE2B
    Synonyms:GAGE2
    AND
    Name:GAGE2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:31957. GAGE2B.
    HGNC:31958. GAGE2C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162389260.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116G antigen 2B/2CPRO_0000148340Add
    BLAST

    Proteomic databases

    MaxQBiQ13066.
    PRIDEiQ13066.

    PTM databases

    PhosphoSiteiQ13066.

    Expressioni

    Tissue specificityi

    Expressed in a variety of tumor tissues but not in normal tissues, except testis.1 Publication

    Gene expression databases

    BgeeiQ13066.
    CleanExiHS_GAGE2B.
    GenevestigatoriQ13066.

    Organism-specific databases

    HPAiHPA043232.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000365350.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13066.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    HOGENOMiHOG000237345.
    HOVERGENiHBG056227.
    OMAiEVEGCAP.
    OrthoDBiEOG7XM316.
    PhylomeDBiQ13066.
    TreeFamiTF340669.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13066-1 [UniParc]FASTAAdd to Basket

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    MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ    50
    DPAAAQEGED EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN 100
    PEEVKTPEEG EKQSQC 116
    Length:116
    Mass (Da):12,786
    Last modified:November 1, 1996 - v1
    Checksum:iDD305D5CA29AF19A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19143 mRNA. Translation: AAA82745.1.
    BX649339 Genomic DNA. Translation: CAI95424.1.
    BX649339 Genomic DNA. Translation: CAI95425.1.
    BC069309 mRNA. Translation: AAH69309.1.
    BC069558 mRNA. Translation: AAH69558.1.
    BC113926 mRNA. Translation: AAI13927.1.
    CCDSiCCDS35260.1.
    CCDS48112.1.
    RefSeqiNP_001091881.1. NM_001098411.3.
    NP_001463.1. NM_001472.2.
    UniGeneiHs.460641.
    Hs.714681.
    Hs.722100.

    Genome annotation databases

    GeneIDi2574.
    645037.
    KEGGihsa:2574.
    hsa:645037.
    UCSCiuc004dnn.4. human.

    Polymorphism databases

    DMDMi3023872.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19143 mRNA. Translation: AAA82745.1 .
    BX649339 Genomic DNA. Translation: CAI95424.1 .
    BX649339 Genomic DNA. Translation: CAI95425.1 .
    BC069309 mRNA. Translation: AAH69309.1 .
    BC069558 mRNA. Translation: AAH69558.1 .
    BC113926 mRNA. Translation: AAI13927.1 .
    CCDSi CCDS35260.1.
    CCDS48112.1.
    RefSeqi NP_001091881.1. NM_001098411.3.
    NP_001463.1. NM_001472.2.
    UniGenei Hs.460641.
    Hs.714681.
    Hs.722100.

    3D structure databases

    ProteinModelPortali Q13066.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000365350.

    PTM databases

    PhosphoSitei Q13066.

    Polymorphism databases

    DMDMi 3023872.

    Proteomic databases

    MaxQBi Q13066.
    PRIDEi Q13066.

    Protocols and materials databases

    DNASUi 2574.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2574.
    645037.
    KEGGi hsa:2574.
    hsa:645037.
    UCSCi uc004dnn.4. human.

    Organism-specific databases

    CTDi 2574.
    645037.
    GeneCardsi GC0XP049226.
    GC0XP049235.
    HGNCi HGNC:31957. GAGE2B.
    HGNC:31958. GAGE2C.
    HPAi HPA043232.
    MIMi 300595. gene.
    300726. gene.
    neXtProti NX_Q13066.
    PharmGKBi PA162389260.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000237345.
    HOVERGENi HBG056227.
    OMAi EVEGCAP.
    OrthoDBi EOG7XM316.
    PhylomeDBi Q13066.
    TreeFami TF340669.

    Miscellaneous databases

    NextBioi 10179.
    PROi Q13066.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13066.
    CleanExi HS_GAGE2B.
    Genevestigatori Q13066.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
      van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
      J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Melanoma.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGAG2B_HUMAN
    AccessioniPrimary (citable) accession number: Q13066
    Secondary accession number(s): C9K0W9, Q4V322
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3