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Q13066 (GAG2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G antigen 2B/2C

Short name=GAGE-2B
Short name=GAGE-2C
Alternative name(s):
Cancer/testis antigen 4.2
Short name=CT4.2
G antigen 2C
Gene names
Name:GAGE2B
Synonyms:GAGE2
AND
Name:GAGE2C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.

Tissue specificity

Expressed in a variety of tumor tissues but not in normal tissues, except testis. Ref.1

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Sequence similarities

Belongs to the GAGE family.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.4 presented a new GAGE gene nomenclature based on the identified genes and their products.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 116116G antigen 2B/2C
PRO_0000148340

Sequences

Sequence LengthMass (Da)Tools
Q13066 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: DD305D5CA29AF19A

FASTA11612,786
        10         20         30         40         50         60 
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED 

        70         80         90        100        110 
EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQC 

« Hide

References

« Hide 'large scale' references
[1]"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Melanoma.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
Gjerstorff M.F., Ditzel H.J.
Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GAGE FAMILY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19143 mRNA. Translation: AAA82745.1.
BX649339 Genomic DNA. Translation: CAI95424.1.
BX649339 Genomic DNA. Translation: CAI95425.1.
BC069309 mRNA. Translation: AAH69309.1.
BC069558 mRNA. Translation: AAH69558.1.
BC113926 mRNA. Translation: AAI13927.1.
CCDSCCDS35260.1.
CCDS48112.1.
RefSeqNP_001091881.1. NM_001098411.3.
NP_001463.1. NM_001472.2.
UniGeneHs.460641.
Hs.714681.
Hs.722100.

3D structure databases

ProteinModelPortalQ13066.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000365350.

PTM databases

PhosphoSiteQ13066.

Polymorphism databases

DMDM3023872.

Proteomic databases

MaxQBQ13066.
PRIDEQ13066.

Protocols and materials databases

DNASU2574.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381708; ENSP00000371127; ENSG00000236249.
ENST00000381725; ENSP00000371144; ENSG00000231850.
GeneID2574.
645037.
KEGGhsa:2574.
hsa:645037.
UCSCuc004dnn.4. human.

Organism-specific databases

CTD2574.
645037.
GeneCardsGC0XP049226.
GC0XP049235.
HGNCHGNC:31957. GAGE2B.
HGNC:31958. GAGE2C.
HPAHPA043232.
MIM300595. gene.
300726. gene.
neXtProtNX_Q13066.
PharmGKBPA162389260.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000237345.
HOVERGENHBG056227.
OMAEVEGCAP.
OrthoDBEOG7XM316.
PhylomeDBQ13066.
TreeFamTF340669.

Gene expression databases

BgeeQ13066.
CleanExHS_GAGE2B.
GenevestigatorQ13066.

Family and domain databases

InterProIPR008625. GAGE.
[Graphical view]
PfamPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio10179.
PROQ13066.
SOURCESearch...

Entry information

Entry nameGAG2B_HUMAN
AccessionPrimary (citable) accession number: Q13066
Secondary accession number(s): C9K0W9, Q4V322
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM