Q13066 (GAG2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G antigen 2B/2C
Short name=GAGE-2B
Short name=GAGE-2C

Alternative name(s):
Cancer/testis antigen 4.2
Short name=CT4.2
G antigen 2C

Gene names

Name:	GAGE2B
Synonyms:	GAGE2
AND
Name:	GAGE2C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.
Tissue specificity	Expressed in a variety of tumor tissues but not in normal tissues, except testis. Ref.1
Miscellaneous	This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T cells.
Sequence similarities	Belongs to the GAGE family.
Caution	The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.5 presented a new GAGE gene nomenclature based on the identified genes and their products.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	G antigen 2B/2C		PRO_0000148340
Amino acid modifications
	Modified residue	39	1	Phosphothreonine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q13066 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: DD305D5CA29AF19A	FASTA	116	12,786
	10 20 30 40 50 60 MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED 70 80 90 100 110 EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma." van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T. J. Exp. Med. 182:689-698(1995) [PubMed: 7544395] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Melanoma.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-39, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members." Gjerstorff M.F., Ditzel H.J. Tissue Antigens 71:187-192(2008) [PubMed: 18179644] [Abstract] Cited for: GAGE FAMILY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19143 mRNA. Translation: AAA82745.1. BX649339 Genomic DNA. Translation: CAI95424.1. BX649339 Genomic DNA. Translation: CAI95425.1. BC069309 mRNA. Translation: AAH69309.1. BC069558 mRNA. Translation: AAH69558.1. BC113926 mRNA. Translation: AAI13927.1.
IPI	IPI00011527.
RefSeq	NP_001463.1. NM_001472.2.
UniGene	Hs.460641. Hs.714681. Hs.722100.
3D structure databases
ProteinModelPortal	Q13066.
ModBase	Search...
Protein-protein interaction databases
STRING	Q13066.
PTM databases
PhosphoSite	Q13066.
Polymorphism databases
DMDM	3023872.
Proteomic databases
PRIDE	Q13066.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376179; ENSP00000365350; ENSG00000236249. ENST00000381708; ENSP00000371127; ENSG00000236249. ENST00000381725; ENSP00000371144; ENSG00000231850. ENST00000407783; ENSP00000385617; ENSG00000236249.
GeneID	2574.
KEGG	hsa:2574.
UCSC	uc004dnr.2. human.
Organism-specific databases
CTD	2574.
GeneCards	GC0XP049226. GC0XP049234.
HGNC	HGNC:31957. GAGE2B. HGNC:31958. GAGE2C.
MIM	300595. gene. 300726. gene.
neXtProt	NX_Q13066.
PharmGKB	PA162389260.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063902.
HOGENOM	HBG507276.
HOVERGEN	HBG056227.
OrthoDB	EOG40S0HR.
Gene expression databases
CleanEx	HS_GAGE2B.
Genevestigator	Q13066.
GermOnline	ENSG00000205775. Homo sapiens. ENSG00000205777. Homo sapiens.
Family and domain databases
InterPro	IPR008625. GAGE. [Graphical view]
Pfam	PF05831. GAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	10179.
SOURCE	Search...

Entry information

Entry name

GAG2B_HUMAN

Accession

Primary (citable) accession number: Q13066
Secondary accession number(s): C9K0W9, Q4V322

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.