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Protein

G antigen 2B/2C

Gene

GAGE2B

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2B/2C
Short name:
GAGE-2B
Short name:
GAGE-2C
Alternative name(s):
Cancer/testis antigen 4.2
Short name:
CT4.2
G antigen 2C
Gene namesi
Name:GAGE2B
Synonyms:GAGE2
AND
Name:GAGE2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31957. GAGE2B.
HGNC:31958. GAGE2C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389260.

Polymorphism and mutation databases

BioMutaiGAGE2B.
DMDMi3023872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483401 – 116G antigen 2B/2CAdd BLAST116

Proteomic databases

MaxQBiQ13066.
PaxDbiQ13066.
PeptideAtlasiQ13066.
PRIDEiQ13066.
TopDownProteomicsiQ13066.

PTM databases

iPTMnetiQ13066.
PhosphoSitePlusiQ13066.

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.1 Publication

Gene expression databases

CleanExiHS_GAGE2B.

Organism-specific databases

HPAiHPA043232.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GMCL1Q96IK54EBI-12329121,EBI-2548508

Protein-protein interaction databases

IntActiQ13066. 3 interactors.
STRINGi9606.ENSP00000371144.

Structurei

3D structure databases

ProteinModelPortaliQ13066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ13066.
PhylomeDBiQ13066.
TreeFamiTF340669.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGED EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN
110
PEEVKTPEEG EKQSQC
Length:116
Mass (Da):12,786
Last modified:November 1, 1996 - v1
Checksum:iDD305D5CA29AF19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19143 mRNA. Translation: AAA82745.1.
BX649339 Genomic DNA. Translation: CAI95424.1.
BX649339 Genomic DNA. Translation: CAI95425.1.
BC069309 mRNA. Translation: AAH69309.1.
BC069558 mRNA. Translation: AAH69558.1.
BC113926 mRNA. Translation: AAI13927.1.
RefSeqiNP_001091881.1. NM_001098411.3.
NP_001463.1. NM_001472.2.
UniGeneiHs.460641.
Hs.714681.
Hs.722100.

Genome annotation databases

GeneIDi2574.
645037.
KEGGihsa:2574.
hsa:645037.

Similar proteinsi

Entry informationi

Entry nameiGAG2B_HUMAN
AccessioniPrimary (citable) accession number: Q13066
Secondary accession number(s): C9K0W9, Q4V322
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families