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Protein

G antigen 1

Gene

GAGE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

GO - Biological processi

  1. cellular defense response Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 1
Short name:
GAGE-1
Alternative name(s):
Antigen MZ2-F
Cancer/testis antigen 4.1
Short name:
CT4.1
Gene namesi
Name:GAGE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:4098. GAGE1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139G antigen 1PRO_0000148339Add
BLAST

Proteomic databases

MaxQBiQ13065.
PaxDbiQ13065.
PRIDEiQ13065.

PTM databases

PhosphoSiteiQ13065.

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Gene expression databases

BgeeiQ13065.
CleanExiHS_GAGE1.
ExpressionAtlasiQ13065. baseline and differential.
GenevestigatoriQ13065.

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

BioGridi108818. 3 interactions.
STRINGi9606.ENSP00000347280.

Structurei

3D structure databases

ProteinModelPortaliQ13065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG293879.
GeneTreeiENSGT00760000119480.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ13065.
OrthoDBiEOG7XM316.
PhylomeDBiQ13065.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13065-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP
110 120 130
NPEEVKTPEE EMRSHYVAQT GILWLLMNNC FLNLSPRKP
Length:139
Mass (Da):15,610
Last modified:May 3, 2011 - v2
Checksum:iAEF5EA1BC7F59811
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111Missing in AAA82744. (PubMed:7544395)Curated
Sequence conflicti19 – 191Q → E in AAA82744. (PubMed:7544395)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19142 mRNA. Translation: AAA82744.1.
AC142496 Genomic DNA. No translation available.
AC142497 Genomic DNA. No translation available.
UniGeneiHs.278606.

Genome annotation databases

EnsembliENST00000381709; ENSP00000371128; ENSG00000205777.
UCSCiuc004dok.2. human.

Polymorphism databases

DMDMi332278184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19142 mRNA. Translation: AAA82744.1.
AC142496 Genomic DNA. No translation available.
AC142497 Genomic DNA. No translation available.
UniGeneiHs.278606.

3D structure databases

ProteinModelPortaliQ13065.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108818. 3 interactions.
STRINGi9606.ENSP00000347280.

PTM databases

PhosphoSiteiQ13065.

Polymorphism databases

DMDMi332278184.

Proteomic databases

MaxQBiQ13065.
PaxDbiQ13065.
PRIDEiQ13065.

Protocols and materials databases

DNASUi2543.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381709; ENSP00000371128; ENSG00000205777.
UCSCiuc004dok.2. human.

Organism-specific databases

GeneCardsiGC0XP049361.
HGNCiHGNC:4098. GAGE1.
HPAiHPA043232.
MIMi300594. gene.
neXtProtiNX_Q13065.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG293879.
GeneTreeiENSGT00760000119480.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ13065.
OrthoDBiEOG7XM316.
PhylomeDBiQ13065.
TreeFamiTF340669.

Miscellaneous databases

NextBioi10035.
PROiQ13065.
SOURCEiSearch...

Gene expression databases

BgeeiQ13065.
CleanExiHS_GAGE1.
ExpressionAtlasiQ13065. baseline and differential.
GenevestigatoriQ13065.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
    van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
    J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Melanoma.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
    De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
    Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
  4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q13065
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 3, 2011
Last modified: February 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.