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Protein

G antigen 1

Gene

GAGE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

GO - Biological processi

  • cellular defense response Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 1
Short name:
GAGE-1
Alternative name(s):
Antigen MZ2-F
Cancer/testis antigen 4.1
Short name:
CT4.1
Gene namesi
Name:GAGE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000205777.17.
HGNCiHGNC:4098. GAGE1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi2543.
2576.
2577.
OpenTargetsiENSG00000205777.

Polymorphism and mutation databases

DMDMi332278184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483391 – 139G antigen 1Add BLAST139

Proteomic databases

MaxQBiQ13065.
PaxDbiQ13065.
PeptideAtlasiQ13065.
PRIDEiQ13065.

PTM databases

iPTMnetiQ13065.
PhosphoSitePlusiQ13065.

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Gene expression databases

BgeeiENSG00000205777.
CleanExiHS_GAGE1.
ExpressionAtlasiQ13065. baseline and differential.
GenevisibleiQ13065. HS.

Organism-specific databases

HPAiHPA043232.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ13065. 3 interactors.
STRINGi9606.ENSP00000371128.

Structurei

3D structure databases

ProteinModelPortaliQ13065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
GeneTreeiENSGT00860000133863.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ13065.
OMAiCECEKQS.
PhylomeDBiQ13065.
TreeFamiTF340669.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP
110 120 130
NPEEVKTPEE EMRSHYVAQT GILWLLMNNC FLNLSPRKP
Length:139
Mass (Da):15,610
Last modified:May 3, 2011 - v2
Checksum:iAEF5EA1BC7F59811
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11Missing in AAA82744 (PubMed:7544395).Curated1
Sequence conflicti19Q → E in AAA82744 (PubMed:7544395).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19142 mRNA. Translation: AAA82744.1.
AC142496 Genomic DNA. No translation available.
AC142497 Genomic DNA. No translation available.
UniGeneiHs.278606.

Genome annotation databases

EnsembliENST00000381709; ENSP00000371128; ENSG00000205777.
UCSCiuc004dok.3. human.

Similar proteinsi

Entry informationi

Entry nameiGAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q13065
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 3, 2011
Last modified: September 27, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families