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Q13065 (GAGE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G antigen 1

Short name=GAGE-1
Alternative name(s):
Antigen MZ2-F
Cancer/testis antigen 4.1
Short name=CT4.1
Gene names
Name:GAGE1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

Tissue specificity

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Sequence similarities

Belongs to the GAGE family.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. Ref.4 presented a new GAGE gene nomenclature based on the identified genes and their products.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular defense response

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 139139G antigen 1
PRO_0000148339

Experimental info

Sequence conflict111Missing in AAA82744. Ref.1
Sequence conflict191Q → E in AAA82744. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q13065 [UniParc].

Last modified May 3, 2011. Version 2.
Checksum: AEF5EA1BC7F59811

FASTA13915,610
        10         20         30         40         50         60 
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE 

        70         80         90        100        110        120 
DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE EMRSHYVAQT 

       130 
GILWLLMNNC FLNLSPRKP 

« Hide

References

« Hide 'large scale' references
[1]"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Melanoma.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
[4]"An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
Gjerstorff M.F., Ditzel H.J.
Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GAGE FAMILY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19142 mRNA. Translation: AAA82744.1.
AC142496 Genomic DNA. No translation available.
AC142497 Genomic DNA. No translation available.
UniGeneHs.278606.

3D structure databases

ProteinModelPortalQ13065.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108818. 1 interaction.
STRING9606.ENSP00000347280.

PTM databases

PhosphoSiteQ13065.

Polymorphism databases

DMDM332278184.

Proteomic databases

MaxQBQ13065.
PaxDbQ13065.
PRIDEQ13065.

Protocols and materials databases

DNASU2543.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381709; ENSP00000371128; ENSG00000205777.
ENST00000595947; ENSP00000473107; ENSG00000269663.
UCSCuc004dok.2. human.

Organism-specific databases

GeneCardsGC0XP049361.
HGNCHGNC:4098. GAGE1.
HPAHPA043232.
MIM300594. gene.
neXtProtNX_Q13065.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293879.
HOGENOMHOG000237345.
HOVERGENHBG056227.
InParanoidQ13065.
OMASHYVAQT.
OrthoDBEOG7XM316.
PhylomeDBQ13065.
TreeFamTF340669.

Gene expression databases

ArrayExpressQ13065.
BgeeQ13065.
CleanExHS_GAGE1.
GenevestigatorQ13065.

Family and domain databases

InterProIPR008625. GAGE.
[Graphical view]
PfamPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio10035.
PROQ13065.
SOURCESearch...

Entry information

Entry nameGAGE1_HUMAN
AccessionPrimary (citable) accession number: Q13065
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM