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Q13065

- GAGE1_HUMAN

UniProt

Q13065 - GAGE1_HUMAN

Protein

G antigen 1

Gene

GAGE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

    GO - Biological processi

    1. cellular defense response Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 1
    Short name:
    GAGE-1
    Alternative name(s):
    Antigen MZ2-F
    Cancer/testis antigen 4.1
    Short name:
    CT4.1
    Gene namesi
    Name:GAGE1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4098. GAGE1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139G antigen 1PRO_0000148339Add
    BLAST

    Proteomic databases

    MaxQBiQ13065.
    PaxDbiQ13065.
    PRIDEiQ13065.

    PTM databases

    PhosphoSiteiQ13065.

    Expressioni

    Tissue specificityi

    Expressed in a variety of tumor tissues but not in normal tissues, except testis.

    Gene expression databases

    ArrayExpressiQ13065.
    BgeeiQ13065.
    CleanExiHS_GAGE1.
    GenevestigatoriQ13065.

    Organism-specific databases

    HPAiHPA043232.

    Interactioni

    Protein-protein interaction databases

    BioGridi108818. 1 interaction.
    STRINGi9606.ENSP00000347280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13065.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    eggNOGiNOG293879.
    HOGENOMiHOG000237345.
    HOVERGENiHBG056227.
    InParanoidiQ13065.
    OMAiSHYVAQT.
    OrthoDBiEOG7XM316.
    PhylomeDBiQ13065.
    TreeFamiTF340669.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13065-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR    50
    QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP 100
    NPEEVKTPEE EMRSHYVAQT GILWLLMNNC FLNLSPRKP 139
    Length:139
    Mass (Da):15,610
    Last modified:May 3, 2011 - v2
    Checksum:iAEF5EA1BC7F59811
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111Missing in AAA82744. (PubMed:7544395)Curated
    Sequence conflicti19 – 191Q → E in AAA82744. (PubMed:7544395)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19142 mRNA. Translation: AAA82744.1.
    AC142496 Genomic DNA. No translation available.
    AC142497 Genomic DNA. No translation available.
    UniGeneiHs.278606.

    Genome annotation databases

    EnsembliENST00000381709; ENSP00000371128; ENSG00000205777.
    UCSCiuc004dok.2. human.

    Polymorphism databases

    DMDMi332278184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19142 mRNA. Translation: AAA82744.1 .
    AC142496 Genomic DNA. No translation available.
    AC142497 Genomic DNA. No translation available.
    UniGenei Hs.278606.

    3D structure databases

    ProteinModelPortali Q13065.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108818. 1 interaction.
    STRINGi 9606.ENSP00000347280.

    PTM databases

    PhosphoSitei Q13065.

    Polymorphism databases

    DMDMi 332278184.

    Proteomic databases

    MaxQBi Q13065.
    PaxDbi Q13065.
    PRIDEi Q13065.

    Protocols and materials databases

    DNASUi 2543.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381709 ; ENSP00000371128 ; ENSG00000205777 .
    UCSCi uc004dok.2. human.

    Organism-specific databases

    GeneCardsi GC0XP049361.
    HGNCi HGNC:4098. GAGE1.
    HPAi HPA043232.
    MIMi 300594. gene.
    neXtProti NX_Q13065.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293879.
    HOGENOMi HOG000237345.
    HOVERGENi HBG056227.
    InParanoidi Q13065.
    OMAi SHYVAQT.
    OrthoDBi EOG7XM316.
    PhylomeDBi Q13065.
    TreeFami TF340669.

    Miscellaneous databases

    NextBioi 10035.
    PROi Q13065.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13065.
    Bgeei Q13065.
    CleanExi HS_GAGE1.
    Genevestigatori Q13065.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."
      van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.
      J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Melanoma.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
      De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
      Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ANTIGENIC PEPTIDES.
    4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGAGE1_HUMAN
    AccessioniPrimary (citable) accession number: Q13065
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3