Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q13049

- TRI32_HUMAN

UniProt

Q13049 - TRI32_HUMAN

Protein

E3 ubiquitin-protein ligase TRIM32

Gene

TRIM32

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 158 (01 Oct 2014)
      Sequence version 2 (16 Apr 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.2 Publications

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri20 – 6546RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri103 – 13331B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. myosin binding Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. protein self-association Source: UniProtKB
    5. RNA binding Source: BHF-UCL
    6. Tat protein binding Source: BHF-UCL
    7. transcription coactivator activity Source: ProtInc
    8. translation initiation factor binding Source: BHF-UCL
    9. ubiquitin binding Source: UniProtKB
    10. ubiquitin-protein transferase activity Source: UniProtKB
    11. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fat cell differentiation Source: BHF-UCL
    2. innate immune response Source: UniProt
    3. negative regulation of fibroblast proliferation Source: BHF-UCL
    4. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
    5. negative regulation of viral release from host cell Source: UniProt
    6. negative regulation of viral transcription Source: UniProt
    7. positive regulation of cell cycle Source: BHF-UCL
    8. positive regulation of cell growth Source: BHF-UCL
    9. positive regulation of cell migration Source: BHF-UCL
    10. positive regulation of cell motility Source: BHF-UCL
    11. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProt
    12. positive regulation of neurogenesis Source: BHF-UCL
    13. positive regulation of neuron differentiation Source: BHF-UCL
    14. positive regulation of NF-kappaB transcription factor activity Source: UniProt
    15. positive regulation of protein catabolic process Source: BHF-UCL
    16. positive regulation of proteolysis Source: BHF-UCL
    17. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProt
    18. positive regulation of type I interferon production Source: Reactome
    19. protein polyubiquitination Source: BHF-UCL
    20. protein ubiquitination Source: BHF-UCL
    21. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
    22. regulation of type I interferon production Source: Reactome
    23. response to tumor necrosis factor Source: BHF-UCL
    24. response to UV Source: BHF-UCL

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_163977. Regulation of innate immune responses to cytosolic DNA.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    SignaLinkiQ13049.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TRIM32 (EC:6.3.2.-)
    Alternative name(s):
    72 kDa Tat-interacting protein
    Tripartite motif-containing protein 32
    Zinc finger protein HT2A
    Gene namesi
    Name:TRIM32
    Synonyms:HT2A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:16380. TRIM32.

    Subcellular locationi

    Cytoplasm
    Note: Localized in cytoplasmic bodies, often located around the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. nucleus Source: BHF-UCL
    4. striated muscle myosin thick filament Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti394 – 3941R → H in LGMD2H. 1 Publication
    VAR_042939
    Natural varianti487 – 4871D → N in LGMD2H. 1 Publication
    VAR_018725
    Natural varianti588 – 5881Missing in LGMD2H. 1 Publication
    VAR_042940
    Bardet-Biedl syndrome 11 (BBS11) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry. It has been suggested that TRIM32 might be the E3 ubiquitin ligase for BBS2, a component of the BBSome complex involved in ciliogenesis, that is ubiquitinated and degraded by the proteasome (PubMed:22500027).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301P → S in BBS11. 1 Publication
    VAR_038807

    Keywords - Diseasei

    Bardet-Biedl syndrome, Ciliopathy, Disease mutation, Limb-girdle muscular dystrophy, Mental retardation, Obesity

    Organism-specific databases

    MIMi209900. phenotype.
    254110. phenotype.
    Orphaneti1878. Autosomal recessive limb-girdle muscular dystrophy type 2H.
    110. Bardet-Biedl syndrome.
    PharmGKBiPA38130.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 653652E3 ubiquitin-protein ligase TRIM32PRO_0000056246Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Post-translational modificationi

    Ubiquitinated.1 Publication

    Keywords - PTMi

    Acetylation, Ubl conjugation

    Proteomic databases

    MaxQBiQ13049.
    PaxDbiQ13049.
    PRIDEiQ13049.

    PTM databases

    PhosphoSiteiQ13049.

    Expressioni

    Tissue specificityi

    Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ13049.
    BgeeiQ13049.
    CleanExiHS_TRIM32.
    GenevestigatoriQ13049.

    Organism-specific databases

    HPAiHPA050060.

    Interactioni

    Subunit structurei

    Interacts with DTNBP1. It self-associates.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATXN1P542532EBI-742790,EBI-930964
    Irak1Q99J342EBI-742790,EBI-6117042From a different organism.
    PDE9AO760833EBI-742790,EBI-742764
    TRIM5Q9C0352EBI-742790,EBI-924214
    UBQLN4Q9NRR53EBI-742790,EBI-711226

    Protein-protein interaction databases

    BioGridi116608. 52 interactions.
    IntActiQ13049. 18 interactions.
    MINTiMINT-2854880.
    STRINGi9606.ENSP00000363095.

    Structurei

    Secondary structure

    1
    653
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni21 – 233
    Beta strandi34 – 363
    Beta strandi38 – 403
    Beta strandi42 – 443
    Helixi45 – 5410
    Turni62 – 643
    Turni73 – 753
    Beta strandi76 – 783
    Turni80 – 834

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CT2NMR-A10-84[»]
    ProteinModelPortaliQ13049.
    SMRiQ13049. Positions 3-90, 353-594, 614-647.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13049.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati358 – 40144NHL 1Add
    BLAST
    Repeati415 – 45844NHL 2Add
    BLAST
    Repeati459 – 49941NHL 3Add
    BLAST
    Repeati562 – 60544NHL 4Add
    BLAST
    Repeati606 – 64641NHL 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili138 – 19760Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 65Poly-Ala

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 5 NHL repeats.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri20 – 6546RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri103 – 13331B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG269289.
    HOGENOMiHOG000120114.
    HOVERGENiHBG060344.
    InParanoidiQ13049.
    KOiK10607.
    OMAiGHTICRQ.
    OrthoDBiEOG7BCNB8.
    PhylomeDBiQ13049.
    TreeFamiTF331018.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR001258. NHL_repeat.
    IPR013017. NHL_repeat_subgr.
    IPR027370. Znf-RING_LisH.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF01436. NHL. 3 hits.
    PF13445. zf-RING_UBOX. 1 hit.
    [Graphical view]
    SMARTiSM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS51125. NHL. 5 hits.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK    50
    LLASSINGVR CPFCSKITRI TSLTQLTDNL TVLKIIDTAG LSEAVGLLMC 100
    RSCGRRLPRQ FCRSCGLVLC EPCREADHQP PGHCTLPVKE AAEERRRDFG 150
    EKLTRLRELM GELQRRKAAL EGVSKDLQAR YKAVLQEYGH EERRVQDELA 200
    RSRKFFTGSL AEVEKSNSQV VEEQSYLLNI AEVQAVSRCD YFLAKIKQAD 250
    VALLEETADE EEPELTASLP RELTLQDVEL LKVGHVGPLQ IGQAVKKPRT 300
    VNVEDSWAME ATASAASTSV TFREMDMSPE EVVASPRASP AKQRGPEAAS 350
    NIQQCLFLKK MGAKGSTPGM FNLPVSLYVT SQGEVLVADR GNYRIQVFTR 400
    KGFLKEIRRS PSGIDSFVLS FLGADLPNLT PLSVAMNCQG LIGVTDSYDN 450
    SLKVYTLDGH CVACHRSQLS KPWGITALPS GQFVVTDVEG GKLWCFTVDR 500
    GSGVVKYSCL CSAVRPKFVT CDAEGTVYFT QGLGLNLENR QNEHHLEGGF 550
    SIGSVGPDGQ LGRQISHFFS ENEDFRCIAG MCVDARGDLI VADSSRKEIL 600
    HFPKGGGYSV LIREGLTCPV GIALTPKGQL LVLDCWDHCI KIYSYHLRRY 650
    STP 653
    Length:653
    Mass (Da):71,989
    Last modified:April 16, 2002 - v2
    Checksum:iD83B1595CA8378FD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271F → I in AAA86474. (PubMed:7778269)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301P → S in BBS11. 1 Publication
    VAR_038807
    Natural varianti257 – 2571T → R.
    Corresponds to variant rs3747834 [ dbSNP | Ensembl ].
    VAR_038808
    Natural varianti299 – 2991R → Q in a patient with Bardet-Biedl syndrome; unknown pathological significance. 1 Publication
    VAR_066295
    Natural varianti394 – 3941R → H in LGMD2H. 1 Publication
    VAR_042939
    Natural varianti408 – 4081R → C.
    Corresponds to variant rs3747835 [ dbSNP | Ensembl ].
    VAR_038809
    Natural varianti487 – 4871D → N in LGMD2H. 1 Publication
    VAR_018725
    Natural varianti588 – 5881Missing in LGMD2H. 1 Publication
    VAR_042940

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18543 mRNA. Translation: AAA86474.1.
    AL133284 Genomic DNA. Translation: CAB92723.1.
    BC003154 mRNA. Translation: AAH03154.1.
    CCDSiCCDS6817.1.
    RefSeqiNP_001093149.1. NM_001099679.1.
    NP_036342.2. NM_012210.3.
    XP_005251870.1. XM_005251813.1.
    UniGeneiHs.591910.

    Genome annotation databases

    EnsembliENST00000373983; ENSP00000363095; ENSG00000119401.
    ENST00000450136; ENSP00000408292; ENSG00000119401.
    GeneIDi22954.
    KEGGihsa:22954.
    UCSCiuc004bjw.2. human.

    Polymorphism databases

    DMDMi20178303.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Leiden Muscular Dystrophy pages

    TRIM32

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18543 mRNA. Translation: AAA86474.1 .
    AL133284 Genomic DNA. Translation: CAB92723.1 .
    BC003154 mRNA. Translation: AAH03154.1 .
    CCDSi CCDS6817.1.
    RefSeqi NP_001093149.1. NM_001099679.1.
    NP_036342.2. NM_012210.3.
    XP_005251870.1. XM_005251813.1.
    UniGenei Hs.591910.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CT2 NMR - A 10-84 [» ]
    ProteinModelPortali Q13049.
    SMRi Q13049. Positions 3-90, 353-594, 614-647.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116608. 52 interactions.
    IntActi Q13049. 18 interactions.
    MINTi MINT-2854880.
    STRINGi 9606.ENSP00000363095.

    PTM databases

    PhosphoSitei Q13049.

    Polymorphism databases

    DMDMi 20178303.

    Proteomic databases

    MaxQBi Q13049.
    PaxDbi Q13049.
    PRIDEi Q13049.

    Protocols and materials databases

    DNASUi 22954.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373983 ; ENSP00000363095 ; ENSG00000119401 .
    ENST00000450136 ; ENSP00000408292 ; ENSG00000119401 .
    GeneIDi 22954.
    KEGGi hsa:22954.
    UCSCi uc004bjw.2. human.

    Organism-specific databases

    CTDi 22954.
    GeneCardsi GC09P119449.
    GeneReviewsi TRIM32.
    HGNCi HGNC:16380. TRIM32.
    HPAi HPA050060.
    MIMi 209900. phenotype.
    254110. phenotype.
    602290. gene.
    neXtProti NX_Q13049.
    Orphaneti 1878. Autosomal recessive limb-girdle muscular dystrophy type 2H.
    110. Bardet-Biedl syndrome.
    PharmGKBi PA38130.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269289.
    HOGENOMi HOG000120114.
    HOVERGENi HBG060344.
    InParanoidi Q13049.
    KOi K10607.
    OMAi GHTICRQ.
    OrthoDBi EOG7BCNB8.
    PhylomeDBi Q13049.
    TreeFami TF331018.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_163977. Regulation of innate immune responses to cytosolic DNA.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    SignaLinki Q13049.

    Miscellaneous databases

    EvolutionaryTracei Q13049.
    GeneWikii TRIM32.
    GenomeRNAii 22954.
    NextBioi 43741.
    PROi Q13049.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13049.
    Bgeei Q13049.
    CleanExi HS_TRIM32.
    Genevestigatori Q13049.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR001258. NHL_repeat.
    IPR013017. NHL_repeat_subgr.
    IPR027370. Znf-RING_LisH.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF01436. NHL. 3 hits.
    PF13445. zf-RING_UBOX. 1 hit.
    [Graphical view ]
    SMARTi SM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS51125. NHL. 5 hits.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins."
      Fridell R.A., Harding L.S., Bogerd H.P., Cullen B.R.
      Virology 209:347-357(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    4. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-15; 51-60; 70-101; 205-238; 248-282; 345-359; 467-500; 587-596 AND 605-613, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryonic kidney.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, UBIQUITINATION, SELF-ASSOCIATION, INTERACTION WITH DTNBP1.
    7. "Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable Bardet-Biedl syndrome protein complex, the BBSome."
      Zhang Q., Yu D., Seo S., Stone E.M., Sheffield V.C.
      J. Biol. Chem. 287:20625-20635(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Solution structure of the RING domain of the tripartite motif protein 32."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 10-84.
    9. "Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene."
      Frosk P., Weiler T., Nylen E., Sudha T., Greenberg C.R., Morgan K., Fujiwara T.M., Wrogemann K.
      Am. J. Hum. Genet. 70:663-672(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LGMD2H ASN-487, TISSUE SPECIFICITY.
    10. Cited for: VARIANT BBS11 SER-130.
    11. "Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H."
      Saccone V., Palmieri M., Passamano L., Piluso G., Meroni G., Politano L., Nigro V.
      Hum. Mutat. 29:240-247(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LGMD2H HIS-394 AND ASP-588 DEL.
    12. Cited for: VARIANT GLN-299.

    Entry informationi

    Entry nameiTRI32_HUMAN
    AccessioniPrimary (citable) accession number: Q13049
    Secondary accession number(s): Q9NQP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 158 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3