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Q13049

- TRI32_HUMAN

UniProt

Q13049 - TRI32_HUMAN

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Protein

E3 ubiquitin-protein ligase TRIM32

Gene

TRIM32

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.2 Publications

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri20 – 6546RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 13331B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. myosin binding Source: BHF-UCL
  3. protein self-association Source: UniProtKB
  4. RNA binding Source: BHF-UCL
  5. Tat protein binding Source: BHF-UCL
  6. transcription coactivator activity Source: ProtInc
  7. translation initiation factor binding Source: BHF-UCL
  8. ubiquitin binding Source: UniProtKB
  9. ubiquitin-protein transferase activity Source: UniProtKB
  10. zinc ion binding Source: InterPro

GO - Biological processi

  1. fat cell differentiation Source: BHF-UCL
  2. innate immune response Source: UniProt
  3. negative regulation of fibroblast proliferation Source: BHF-UCL
  4. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  5. negative regulation of viral release from host cell Source: UniProt
  6. negative regulation of viral transcription Source: UniProt
  7. positive regulation of cell cycle Source: BHF-UCL
  8. positive regulation of cell growth Source: BHF-UCL
  9. positive regulation of cell migration Source: BHF-UCL
  10. positive regulation of cell motility Source: BHF-UCL
  11. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProt
  12. positive regulation of neurogenesis Source: BHF-UCL
  13. positive regulation of neuron differentiation Source: BHF-UCL
  14. positive regulation of NF-kappaB transcription factor activity Source: UniProt
  15. positive regulation of protein catabolic process Source: BHF-UCL
  16. positive regulation of proteolysis Source: BHF-UCL
  17. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProt
  18. positive regulation of type I interferon production Source: Reactome
  19. protein polyubiquitination Source: BHF-UCL
  20. protein ubiquitination Source: BHF-UCL
  21. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  22. regulation of type I interferon production Source: Reactome
  23. response to tumor necrosis factor Source: BHF-UCL
  24. response to UV Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_163977. Regulation of innate immune responses to cytosolic DNA.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ13049.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM32 (EC:6.3.2.-)
Alternative name(s):
72 kDa Tat-interacting protein
Tripartite motif-containing protein 32
Zinc finger protein HT2A
Gene namesi
Name:TRIM32
Synonyms:HT2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16380. TRIM32.

Subcellular locationi

Cytoplasm
Note: Localized in cytoplasmic bodies, often located around the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. nucleus Source: BHF-UCL
  4. striated muscle myosin thick filament Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti394 – 3941R → H in LGMD2H. 1 Publication
VAR_042939
Natural varianti487 – 4871D → N in LGMD2H. 1 Publication
VAR_018725
Natural varianti588 – 5881Missing in LGMD2H. 1 Publication
VAR_042940
Bardet-Biedl syndrome 11 (BBS11) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry. It has been suggested that TRIM32 might be the E3 ubiquitin ligase for BBS2, a component of the BBSome complex involved in ciliogenesis, that is ubiquitinated and degraded by the proteasome (PubMed:22500027).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301P → S in BBS11. 1 Publication
VAR_038807

Keywords - Diseasei

Bardet-Biedl syndrome, Ciliopathy, Disease mutation, Limb-girdle muscular dystrophy, Mental retardation, Obesity

Organism-specific databases

MIMi209900. phenotype.
254110. phenotype.
Orphaneti1878. Autosomal recessive limb-girdle muscular dystrophy type 2H.
110. Bardet-Biedl syndrome.
PharmGKBiPA38130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 653652E3 ubiquitin-protein ligase TRIM32PRO_0000056246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

MaxQBiQ13049.
PaxDbiQ13049.
PRIDEiQ13049.

PTM databases

PhosphoSiteiQ13049.

Expressioni

Tissue specificityi

Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ13049.
CleanExiHS_TRIM32.
ExpressionAtlasiQ13049. baseline and differential.
GenevestigatoriQ13049.

Organism-specific databases

HPAiHPA050060.

Interactioni

Subunit structurei

Interacts with DTNBP1. It self-associates.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542532EBI-742790,EBI-930964
Irak1Q99J342EBI-742790,EBI-6117042From a different organism.
PDE9AO760833EBI-742790,EBI-742764
TRIM5Q9C0352EBI-742790,EBI-924214
UBQLN4Q9NRR53EBI-742790,EBI-711226

Protein-protein interaction databases

BioGridi116608. 60 interactions.
IntActiQ13049. 18 interactions.
MINTiMINT-2854880.
STRINGi9606.ENSP00000363095.

Structurei

Secondary structure

1
653
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni21 – 233
Beta strandi34 – 363
Beta strandi38 – 403
Beta strandi42 – 443
Helixi45 – 5410
Turni62 – 643
Turni73 – 753
Beta strandi76 – 783
Turni80 – 834

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CT2NMR-A10-84[»]
ProteinModelPortaliQ13049.
SMRiQ13049. Positions 3-90, 353-594.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13049.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati358 – 40144NHL 1Add
BLAST
Repeati415 – 45844NHL 2Add
BLAST
Repeati459 – 49941NHL 3Add
BLAST
Repeati562 – 60544NHL 4Add
BLAST
Repeati606 – 64641NHL 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili138 – 19760Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 65Poly-Ala

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 5 NHL repeats.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri20 – 6546RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 13331B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG269289.
GeneTreeiENSGT00550000074377.
HOGENOMiHOG000120114.
HOVERGENiHBG060344.
InParanoidiQ13049.
KOiK10607.
OMAiGHTICRQ.
OrthoDBiEOG7BCNB8.
PhylomeDBiQ13049.
TreeFamiTF331018.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF01436. NHL. 3 hits.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51125. NHL. 5 hits.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13049-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK
60 70 80 90 100
LLASSINGVR CPFCSKITRI TSLTQLTDNL TVLKIIDTAG LSEAVGLLMC
110 120 130 140 150
RSCGRRLPRQ FCRSCGLVLC EPCREADHQP PGHCTLPVKE AAEERRRDFG
160 170 180 190 200
EKLTRLRELM GELQRRKAAL EGVSKDLQAR YKAVLQEYGH EERRVQDELA
210 220 230 240 250
RSRKFFTGSL AEVEKSNSQV VEEQSYLLNI AEVQAVSRCD YFLAKIKQAD
260 270 280 290 300
VALLEETADE EEPELTASLP RELTLQDVEL LKVGHVGPLQ IGQAVKKPRT
310 320 330 340 350
VNVEDSWAME ATASAASTSV TFREMDMSPE EVVASPRASP AKQRGPEAAS
360 370 380 390 400
NIQQCLFLKK MGAKGSTPGM FNLPVSLYVT SQGEVLVADR GNYRIQVFTR
410 420 430 440 450
KGFLKEIRRS PSGIDSFVLS FLGADLPNLT PLSVAMNCQG LIGVTDSYDN
460 470 480 490 500
SLKVYTLDGH CVACHRSQLS KPWGITALPS GQFVVTDVEG GKLWCFTVDR
510 520 530 540 550
GSGVVKYSCL CSAVRPKFVT CDAEGTVYFT QGLGLNLENR QNEHHLEGGF
560 570 580 590 600
SIGSVGPDGQ LGRQISHFFS ENEDFRCIAG MCVDARGDLI VADSSRKEIL
610 620 630 640 650
HFPKGGGYSV LIREGLTCPV GIALTPKGQL LVLDCWDHCI KIYSYHLRRY

STP
Length:653
Mass (Da):71,989
Last modified:April 16, 2002 - v2
Checksum:iD83B1595CA8378FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271F → I in AAA86474. (PubMed:7778269)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301P → S in BBS11. 1 Publication
VAR_038807
Natural varianti257 – 2571T → R.
Corresponds to variant rs3747834 [ dbSNP | Ensembl ].
VAR_038808
Natural varianti299 – 2991R → Q in a patient with Bardet-Biedl syndrome; unknown pathological significance. 1 Publication
VAR_066295
Natural varianti394 – 3941R → H in LGMD2H. 1 Publication
VAR_042939
Natural varianti408 – 4081R → C.
Corresponds to variant rs3747835 [ dbSNP | Ensembl ].
VAR_038809
Natural varianti487 – 4871D → N in LGMD2H. 1 Publication
VAR_018725
Natural varianti588 – 5881Missing in LGMD2H. 1 Publication
VAR_042940

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18543 mRNA. Translation: AAA86474.1.
AL133284 Genomic DNA. Translation: CAB92723.1.
BC003154 mRNA. Translation: AAH03154.1.
CCDSiCCDS6817.1.
RefSeqiNP_001093149.1. NM_001099679.1.
NP_036342.2. NM_012210.3.
XP_005251870.1. XM_005251813.1.
UniGeneiHs.591910.

Genome annotation databases

EnsembliENST00000373983; ENSP00000363095; ENSG00000119401.
ENST00000450136; ENSP00000408292; ENSG00000119401.
GeneIDi22954.
KEGGihsa:22954.
UCSCiuc004bjw.2. human.

Polymorphism databases

DMDMi20178303.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Leiden Muscular Dystrophy pages

TRIM32

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18543 mRNA. Translation: AAA86474.1 .
AL133284 Genomic DNA. Translation: CAB92723.1 .
BC003154 mRNA. Translation: AAH03154.1 .
CCDSi CCDS6817.1.
RefSeqi NP_001093149.1. NM_001099679.1.
NP_036342.2. NM_012210.3.
XP_005251870.1. XM_005251813.1.
UniGenei Hs.591910.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CT2 NMR - A 10-84 [» ]
ProteinModelPortali Q13049.
SMRi Q13049. Positions 3-90, 353-594.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116608. 60 interactions.
IntActi Q13049. 18 interactions.
MINTi MINT-2854880.
STRINGi 9606.ENSP00000363095.

PTM databases

PhosphoSitei Q13049.

Polymorphism databases

DMDMi 20178303.

Proteomic databases

MaxQBi Q13049.
PaxDbi Q13049.
PRIDEi Q13049.

Protocols and materials databases

DNASUi 22954.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373983 ; ENSP00000363095 ; ENSG00000119401 .
ENST00000450136 ; ENSP00000408292 ; ENSG00000119401 .
GeneIDi 22954.
KEGGi hsa:22954.
UCSCi uc004bjw.2. human.

Organism-specific databases

CTDi 22954.
GeneCardsi GC09P119449.
GeneReviewsi TRIM32.
HGNCi HGNC:16380. TRIM32.
HPAi HPA050060.
MIMi 209900. phenotype.
254110. phenotype.
602290. gene.
neXtProti NX_Q13049.
Orphaneti 1878. Autosomal recessive limb-girdle muscular dystrophy type 2H.
110. Bardet-Biedl syndrome.
PharmGKBi PA38130.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269289.
GeneTreei ENSGT00550000074377.
HOGENOMi HOG000120114.
HOVERGENi HBG060344.
InParanoidi Q13049.
KOi K10607.
OMAi GHTICRQ.
OrthoDBi EOG7BCNB8.
PhylomeDBi Q13049.
TreeFami TF331018.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_163977. Regulation of innate immune responses to cytosolic DNA.
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinki Q13049.

Miscellaneous databases

EvolutionaryTracei Q13049.
GeneWikii TRIM32.
GenomeRNAii 22954.
NextBioi 43741.
PROi Q13049.
SOURCEi Search...

Gene expression databases

Bgeei Q13049.
CleanExi HS_TRIM32.
ExpressionAtlasi Q13049. baseline and differential.
Genevestigatori Q13049.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF01436. NHL. 3 hits.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view ]
SMARTi SM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS51125. NHL. 5 hits.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins."
    Fridell R.A., Harding L.S., Bogerd H.P., Cullen B.R.
    Virology 209:347-357(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-15; 51-60; 70-101; 205-238; 248-282; 345-359; 467-500; 587-596 AND 605-613, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic kidney.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, UBIQUITINATION, SELF-ASSOCIATION, INTERACTION WITH DTNBP1.
  7. "Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable Bardet-Biedl syndrome protein complex, the BBSome."
    Zhang Q., Yu D., Seo S., Stone E.M., Sheffield V.C.
    J. Biol. Chem. 287:20625-20635(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Solution structure of the RING domain of the tripartite motif protein 32."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 10-84.
  9. "Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene."
    Frosk P., Weiler T., Nylen E., Sudha T., Greenberg C.R., Morgan K., Fujiwara T.M., Wrogemann K.
    Am. J. Hum. Genet. 70:663-672(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LGMD2H ASN-487, TISSUE SPECIFICITY.
  10. Cited for: VARIANT BBS11 SER-130.
  11. "Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H."
    Saccone V., Palmieri M., Passamano L., Piluso G., Meroni G., Politano L., Nigro V.
    Hum. Mutat. 29:240-247(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LGMD2H HIS-394 AND ASP-588 DEL.
  12. Cited for: VARIANT GLN-299.

Entry informationi

Entry nameiTRI32_HUMAN
AccessioniPrimary (citable) accession number: Q13049
Secondary accession number(s): Q9NQP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: October 29, 2014
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3