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Protein

Putative pregnancy-specific beta-1-glycoprotein 7

Gene

PSG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

GO - Biological processi

  • female pregnancy Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pregnancy-specific beta-1-glycoprotein 7
Short name:
PS-beta-G-7
Short name:
PSBG-7
Short name:
Pregnancy-specific glycoprotein 7
Gene namesi
Name:PSG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000221878.10
HGNCiHGNC:9524 PSG7
MIMi176396 gene
neXtProtiNX_Q13046

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5676
OpenTargetsiENSG00000221878
PharmGKBiPA33869

Polymorphism and mutation databases

BioMutaiPSG7
DMDMi108935881

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491435 – 419Putative pregnancy-specific beta-1-glycoprotein 7Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ13046
PeptideAtlasiQ13046
PRIDEiQ13046

PTM databases

iPTMnetiQ13046
PhosphoSitePlusiQ13046

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000221878
CleanExiHS_PSG7
ExpressionAtlasiA0A087WSZ1 baseline and differential

Organism-specific databases

HPAiHPA046327

Structurei

3D structure databases

ProteinModelPortaliQ13046
SMRiQ13046
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini240 – 327Ig-like C2-type 2Add BLAST88
Domaini335 – 410Ig-like C2-type 3Add BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00760000119187
HOVERGENiHBG007922
InParanoidiQ13046
KOiK06500

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QIRDLYHYVT SYIVDGQIIK YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTQEDTGSY TLHIIKRGDG TGGVTGRFTF TLYLETPKPS
160 170 180 190 200
ISSSNFNPRE ATEAVILTCD PETPDASYLW WMNGQSLPMT HSLQLSETNR
210 220 230 240 250
TLYLFGVTNY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN
260 270 280 290 300
PRENKDVSTF TCEPKSENYT YIWWLNGQSL PVSPRVKRRI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYHSGQNL
360 370 380 390 400
YLSCFADSNP PAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA
410
TGKESSKSVT VRVSDWTLP
Length:419
Mass (Da):47,027
Last modified:March 28, 2018 - v3
Checksum:i57219C6FB683BF33
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83I → V in AAA75293 (PubMed:7794280).Curated1
Sequence conflicti233 – 237LNLLP → IIVPV in AAA60200 (PubMed:1690992).Curated5
Sequence conflicti348Q → E in AAA60200 (PubMed:1690992).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05607565Y → H. Corresponds to variant dbSNP:rs7245978Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18467 mRNA Translation: AAA75293.1
AC005260 Genomic DNA No translation available.
KF454892 Genomic DNA No translation available.
AC093055 Genomic DNA No translation available.
M32619, M32617, M32618 Genomic DNA Translation: AAA60200.1
PIRiI83053
JC4123
RefSeqiNP_002774.2, NM_002783.2
UniGeneiHs.709203

Genome annotation databases

EnsembliENST00000406070; ENSP00000421986; ENSG00000221878
GeneIDi5676
KEGGihsa:5676

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPSG7_HUMAN
AccessioniPrimary (citable) accession number: Q13046
Secondary accession number(s): A0A087WSZ1, Q15232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health