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Protein

Putative pregnancy-specific beta-1-glycoprotein 7

Gene

PSG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pregnancy-specific beta-1-glycoprotein 7
Short name:
PS-beta-G-7
Short name:
PSBG-7
Short name:
Pregnancy-specific glycoprotein 7
Gene namesi
Name:PSG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9524. PSG7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5676.
PharmGKBiPA33869.

Polymorphism and mutation databases

BioMutaiPSG7.
DMDMi108935881.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491435 – 419Putative pregnancy-specific beta-1-glycoprotein 7Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ13046.
PeptideAtlasiQ13046.
PRIDEiQ13046.

PTM databases

iPTMnetiQ13046.
PhosphoSitePlusiQ13046.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

CleanExiHS_PSG7.

Organism-specific databases

HPAiHPA046327.

Structurei

3D structure databases

ProteinModelPortaliQ13046.
SMRiQ13046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini240 – 327Ig-like C2-type 2Add BLAST88
Domaini335 – 410Ig-like C2-type 3Add BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG007922.
InParanoidiQ13046.
KOiK06500.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGHIWYKG QIRDLYHYVT SYIVDGQIIK YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTQEDTGSY TLHIIKRGDG TGGVTGRFTF TLYLETPKPS
160 170 180 190 200
ISSSNFNPRE ATEAVILTCD PETPDASYLW WMNGQSLPMT HSLQLSETNR
210 220 230 240 250
TLYLFGVTNY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN
260 270 280 290 300
PRENKDVSTF TCEPKSENYT YIWWLNGQSL PVSPRVKRRI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYHSGQNL
360 370 380 390 400
YLSCFADSNP PAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA
410
TGKESSKSVT VRVSDWTLP
Length:419
Mass (Da):47,001
Last modified:June 13, 2006 - v2
Checksum:i70FAF23F4CDC1C7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83I → V in AAA75293 (PubMed:7794280).Curated1
Sequence conflicti233 – 237LNLLP → IIVPV (PubMed:1690992).Curated5
Sequence conflicti348Q → E in AAA60200 (PubMed:1690992).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05607565H → Y.1 PublicationCorresponds to variant rs7245978dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18467 mRNA. Translation: AAA75293.1.
AC005260 Genomic DNA. Translation: AAC25621.1.
AC093055 Genomic DNA. No translation available.
M32619, M32617, M32618 Genomic DNA. Translation: AAA60200.1.
PIRiI83053.
JC4123.
RefSeqiNP_002774.2. NM_002783.2.
UniGeneiHs.709203.

Genome annotation databases

GeneIDi5676.
KEGGihsa:5676.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18467 mRNA. Translation: AAA75293.1.
AC005260 Genomic DNA. Translation: AAC25621.1.
AC093055 Genomic DNA. No translation available.
M32619, M32617, M32618 Genomic DNA. Translation: AAA60200.1.
PIRiI83053.
JC4123.
RefSeqiNP_002774.2. NM_002783.2.
UniGeneiHs.709203.

3D structure databases

ProteinModelPortaliQ13046.
SMRiQ13046.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ13046.
PhosphoSitePlusiQ13046.

Polymorphism and mutation databases

BioMutaiPSG7.
DMDMi108935881.

Proteomic databases

MaxQBiQ13046.
PeptideAtlasiQ13046.
PRIDEiQ13046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5676.
KEGGihsa:5676.

Organism-specific databases

CTDi5676.
DisGeNETi5676.
GeneCardsiPSG7.
HGNCiHGNC:9524. PSG7.
HPAiHPA046327.
MIMi176396. gene.
neXtProtiNX_Q13046.
PharmGKBiPA33869.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG007922.
InParanoidiQ13046.
KOiK06500.

Miscellaneous databases

GenomeRNAii5676.
PROiQ13046.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PSG7.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG7_HUMAN
AccessioniPrimary (citable) accession number: Q13046
Secondary accession number(s): Q15232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 13, 2006
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.