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Protein

Putative pregnancy-specific beta-1-glycoprotein 7

Gene

PSG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pregnancy-specific beta-1-glycoprotein 7
Short name:
PS-beta-G-7
Short name:
PSBG-7
Short name:
Pregnancy-specific glycoprotein 7
Gene namesi
Name:PSG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9524. PSG7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33869.

Polymorphism and mutation databases

BioMutaiPSG7.
DMDMi108935881.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 419385Putative pregnancy-specific beta-1-glycoprotein 7PRO_0000014914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi169 ↔ 217Curated
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi262 ↔ 310Curated
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ13046.
PRIDEiQ13046.

PTM databases

iPTMnetiQ13046.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

CleanExiHS_PSG7.

Organism-specific databases

HPAiHPA046327.

Structurei

3D structure databases

ProteinModelPortaliQ13046.
SMRiQ13046. Positions 34-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-typeAdd
BLAST
Domaini147 – 23488Ig-like C2-type 1Add
BLAST
Domaini240 – 32788Ig-like C2-type 2Add
BLAST
Domaini335 – 41076Ig-like C2-type 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1293Cell attachment siteSequence analysis

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG007922.
InParanoidiQ13046.
KOiK06500.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGHIWYKG QIRDLYHYVT SYIVDGQIIK YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTQEDTGSY TLHIIKRGDG TGGVTGRFTF TLYLETPKPS
160 170 180 190 200
ISSSNFNPRE ATEAVILTCD PETPDASYLW WMNGQSLPMT HSLQLSETNR
210 220 230 240 250
TLYLFGVTNY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN
260 270 280 290 300
PRENKDVSTF TCEPKSENYT YIWWLNGQSL PVSPRVKRRI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYHSGQNL
360 370 380 390 400
YLSCFADSNP PAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA
410
TGKESSKSVT VRVSDWTLP
Length:419
Mass (Da):47,001
Last modified:June 13, 2006 - v2
Checksum:i70FAF23F4CDC1C7E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831I → V in AAA75293 (PubMed:7794280).Curated
Sequence conflicti233 – 2375LNLLP → IIVPV (PubMed:1690992).Curated
Sequence conflicti348 – 3481Q → E in AAA60200 (PubMed:1690992).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651H → Y.1 Publication
Corresponds to variant rs7245978 [ dbSNP | Ensembl ].
VAR_056075

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18467 mRNA. Translation: AAA75293.1.
AC005260 Genomic DNA. Translation: AAC25621.1.
AC093055 Genomic DNA. No translation available.
M32619, M32617, M32618 Genomic DNA. Translation: AAA60200.1.
PIRiI83053.
JC4123.
RefSeqiNP_002774.2. NM_002783.2.
UniGeneiHs.709203.

Genome annotation databases

GeneIDi5676.
KEGGihsa:5676.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18467 mRNA. Translation: AAA75293.1.
AC005260 Genomic DNA. Translation: AAC25621.1.
AC093055 Genomic DNA. No translation available.
M32619, M32617, M32618 Genomic DNA. Translation: AAA60200.1.
PIRiI83053.
JC4123.
RefSeqiNP_002774.2. NM_002783.2.
UniGeneiHs.709203.

3D structure databases

ProteinModelPortaliQ13046.
SMRiQ13046. Positions 34-411.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ13046.

Polymorphism and mutation databases

BioMutaiPSG7.
DMDMi108935881.

Proteomic databases

PeptideAtlasiQ13046.
PRIDEiQ13046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5676.
KEGGihsa:5676.

Organism-specific databases

CTDi5676.
GeneCardsiPSG7.
HGNCiHGNC:9524. PSG7.
HPAiHPA046327.
MIMi176396. gene.
neXtProtiNX_Q13046.
PharmGKBiPA33869.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG007922.
InParanoidiQ13046.
KOiK06500.

Miscellaneous databases

GenomeRNAii5676.
PROiQ13046.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PSG7.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants."
    Teglund S., Zhou G.Q., Hammarstroem S.
    Biochem. Biophys. Res. Commun. 211:656-664(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-65.
    Tissue: Liver.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed."
    Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H., Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D., Hardman N.
    Biochem. Biophys. Res. Commun. 167:848-859(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-414.

Entry informationi

Entry nameiPSG7_HUMAN
AccessioniPrimary (citable) accession number: Q13046
Secondary accession number(s): Q15232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 13, 2006
Last modified: July 6, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.