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Protein

Protein flightless-1 homolog

Gene

FLII

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177731-MONOMER.
SIGNORiQ13045.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein flightless-1 homolog
Gene namesi
Name:FLII
Synonyms:FLIL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:3750. FLII.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi586E → K: No change in ESR1 binding but reduced binding to ACTL6A and reduced coactivator function. 1 Publication1
Mutagenesisi603G → S: No change in binding to ACTL6A or in coactivator function. 1 Publication1

Organism-specific databases

DisGeNETi2314.
MalaCardsiFLII.
OpenTargetsiENSG00000177731.
Orphaneti819. Smith-Magenis syndrome.
PharmGKBiPA28171.

Polymorphism and mutation databases

BioMutaiFLII.
DMDMi18202493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187501 – 1269Protein flightless-1 homologAdd BLAST1269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei436Phosphoserine; by SGK3Combined sources1 Publication1
Modified residuei818Phosphothreonine; by SGK31 Publication1
Modified residuei856PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13045.
MaxQBiQ13045.
PaxDbiQ13045.
PeptideAtlasiQ13045.
PRIDEiQ13045.

PTM databases

iPTMnetiQ13045.
PhosphoSitePlusiQ13045.

Expressioni

Tissue specificityi

Strongest expression in skeletal muscle with high expression also in the heart and lung.1 Publication

Gene expression databases

BgeeiENSG00000177731.
CleanExiHS_FLII.
ExpressionAtlasiQ13045. baseline and differential.
GenevisibleiQ13045. HS.

Organism-specific databases

HPAiCAB016132.
HPA007084.
HPA008903.

Interactioni

Subunit structurei

Interacts with actin, ACTL6A, NCOA2, CARM1 and MYD88. Interacts with LRRFIP1 and LRRFIP2. Upon LPS stimulation, LRRFIP2 competes for MYD88-binding. LRRFIP1 constitutively blocks the interaction with MyD88, even in the absence of LPS. Interacts with the nuclear receptors ESR1 and THRB. Interacts with SGK3.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRFIP1Q32MZ42EBI-351549,EBI-1369100

GO - Molecular functioni

  • actin binding Source: HGNC

Protein-protein interaction databases

BioGridi108603. 79 interactors.
IntActiQ13045. 43 interactors.
MINTiMINT-1399971.
STRINGi9606.ENSP00000324573.

Structurei

3D structure databases

ProteinModelPortaliQ13045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 32LRR 1Add BLAST26
Repeati33 – 55LRR 2Add BLAST23
Repeati56 – 78LRR 3Add BLAST23
Repeati80 – 103LRR 4Add BLAST24
Repeati104 – 126LRR 5Add BLAST23
Repeati127 – 149LRR 6Add BLAST23
Repeati150 – 173LRR 7Add BLAST24
Repeati175 – 196LRR 8Add BLAST22
Repeati197 – 222LRR 9Add BLAST26
Repeati223 – 245LRR 10Add BLAST23
Repeati247 – 268LRR 11Add BLAST22
Repeati269 – 291LRR 12Add BLAST23
Repeati293 – 316LRR 13Add BLAST24
Repeati318 – 339LRR 14Add BLAST22
Repeati340 – 363LRR 15Add BLAST24
Repeati501 – 559Gelsolin-like 1Add BLAST59
Repeati640 – 670Gelsolin-like 2Add BLAST31
Repeati755 – 798Gelsolin-like 3Add BLAST44
Repeati1068 – 1115Gelsolin-like 4Add BLAST48
Repeati1176 – 1218Gelsolin-like 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 427Interaction with LRRFIP1 and LRRFIP2Add BLAST427
Regioni495 – 827Interaction with ACTL6A1 PublicationAdd BLAST333

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi411 – 415Poly-Ala5
Compositional biasi892 – 978Glu-richAdd BLAST87

Sequence similaritiesi

Contains 5 gelsolin-like repeats.Curated
Contains 15 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0444. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000016110.
HOVERGENiHBG051627.
InParanoidiQ13045.
OMAiQMKADLT.
OrthoDBiEOG091G00R0.
PhylomeDBiQ13045.
TreeFamiTF313468.

Family and domain databases

Gene3Di3.40.20.10. 7 hits.
3.80.10.10. 3 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR029919. FliI.
IPR007123. Gelsolin-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF42. PTHR11977:SF42. 1 hit.
PfamiPF00626. Gelsolin. 4 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13045-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE
60 70 80 90 100
ELAALQKLEH LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI
110 120 130 140 150
FKLDDLSVLD LSHNQLTECP RELENAKNML VLNLSHNSID TIPNQLFINL
160 170 180 190 200
TDLLYLDLSE NRLESLPPQM RRLVHLQTLV LNGNPLLHAQ LRQLPAMTAL
210 220 230 240 250
QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE CLYTLPSLRR
260 270 280 290 300
LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN
310 320 330 340 350
SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN
360 370 380 390 400
HLVTLPEAIH FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL
410 420 430 440 450
RLAGASPATV AAAAAAGSGP KDPMARKMRL RRRKDSAQDD QAKQVLKGMS
460 470 480 490 500
DVAQEKNKKQ EESADARAPS GKVRRWDQGL EKPRLDYSEF FTEDVGQLPG
510 520 530 540 550
LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS LNWEIYYWIG
560 570 580 590 600
GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY
610 620 630 640 650
IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL
660 670 680 690 700
DRGLDIYVWR GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP
710 720 730 740 750
EFWEALGGEP SEIKKHVPED FWPPQPKLYK VGLGLGYLEL PQINYKLSVE
760 770 780 790 800
HKQRPKVELM PRMRLLQSLL DTRCVYILDC WSDVFIWLGR KSPRLVRAAA
810 820 830 840 850
LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD VLTVDYTRNA
860 870 880 890 900
EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW
910 920 930 940 950
NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE
960 970 980 990 1000
KKEDKEEKAE GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF
1010 1020 1030 1040 1050
TFSLQKKFES LFPGKLEVVR MTQQQENPKF LSHFKRKFII HRGKRKAVQG
1060 1070 1080 1090 1100
AQQPSLYQIR TNGSALCTRC IQINTDSSLL NSEFCFILKV PFESEDNQGI
1110 1120 1130 1140 1150
VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP ENFFWVGIGA
1160 1170 1180 1190 1200
QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN
1210 1220 1230 1240 1250
GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE
1260
QHAFTRCFHA WSAFCKALA
Length:1,269
Mass (Da):144,751
Last modified:January 1, 1998 - v2
Checksum:i29AC7C07738B7B47
GO
Isoform 2 (identifier: Q13045-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-191: Missing.
     416-416: Missing.

Note: No experimental confirmation available.
Show »
Length:1,214
Mass (Da):138,493
Checksum:iC0ACCF1BB28C366C
GO
Isoform 3 (identifier: Q13045-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEATGVLPFVRGVDLSGNDFK → MDLRGLRPVP

Show »
Length:1,258
Mass (Da):143,652
Checksum:i8D087C091CFAD08B
GO

Sequence cautioni

The sequence BAG58522 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in BAG58522 (PubMed:14702039).Curated1
Sequence conflicti298Y → N in BAG58522 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0292581243R → H.Corresponds to variant rs8821dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468871 – 21MEATG…GNDFK → MDLRGLRPVP in isoform 3. CuratedAdd BLAST21
Alternative sequenceiVSP_044686138 – 191Missing in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_044687416Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80184 Genomic DNA. Translation: AAC02796.1.
AK295655 mRNA. Translation: BAG58522.1. Different initiation.
AC127537 Genomic DNA. No translation available.
BC025300 mRNA. Translation: AAH25300.1.
U01184 mRNA. Translation: AAC03568.1.
CCDSiCCDS11192.1. [Q13045-1]
CCDS58521.1. [Q13045-3]
CCDS58522.1. [Q13045-2]
PIRiA49674.
RefSeqiNP_001243193.1. NM_001256264.1. [Q13045-3]
NP_001243194.1. NM_001256265.1. [Q13045-2]
NP_002009.1. NM_002018.3. [Q13045-1]
UniGeneiHs.513984.

Genome annotation databases

EnsembliENST00000327031; ENSP00000324573; ENSG00000177731. [Q13045-1]
ENST00000545457; ENSP00000438536; ENSG00000177731. [Q13045-2]
ENST00000579294; ENSP00000463534; ENSG00000177731. [Q13045-3]
GeneIDi2314.
KEGGihsa:2314.
UCSCiuc002gsr.3. human. [Q13045-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80184 Genomic DNA. Translation: AAC02796.1.
AK295655 mRNA. Translation: BAG58522.1. Different initiation.
AC127537 Genomic DNA. No translation available.
BC025300 mRNA. Translation: AAH25300.1.
U01184 mRNA. Translation: AAC03568.1.
CCDSiCCDS11192.1. [Q13045-1]
CCDS58521.1. [Q13045-3]
CCDS58522.1. [Q13045-2]
PIRiA49674.
RefSeqiNP_001243193.1. NM_001256264.1. [Q13045-3]
NP_001243194.1. NM_001256265.1. [Q13045-2]
NP_002009.1. NM_002018.3. [Q13045-1]
UniGeneiHs.513984.

3D structure databases

ProteinModelPortaliQ13045.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108603. 79 interactors.
IntActiQ13045. 43 interactors.
MINTiMINT-1399971.
STRINGi9606.ENSP00000324573.

PTM databases

iPTMnetiQ13045.
PhosphoSitePlusiQ13045.

Polymorphism and mutation databases

BioMutaiFLII.
DMDMi18202493.

Proteomic databases

EPDiQ13045.
MaxQBiQ13045.
PaxDbiQ13045.
PeptideAtlasiQ13045.
PRIDEiQ13045.

Protocols and materials databases

DNASUi2314.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327031; ENSP00000324573; ENSG00000177731. [Q13045-1]
ENST00000545457; ENSP00000438536; ENSG00000177731. [Q13045-2]
ENST00000579294; ENSP00000463534; ENSG00000177731. [Q13045-3]
GeneIDi2314.
KEGGihsa:2314.
UCSCiuc002gsr.3. human. [Q13045-1]

Organism-specific databases

CTDi2314.
DisGeNETi2314.
GeneCardsiFLII.
HGNCiHGNC:3750. FLII.
HPAiCAB016132.
HPA007084.
HPA008903.
MalaCardsiFLII.
MIMi600362. gene.
neXtProtiNX_Q13045.
OpenTargetsiENSG00000177731.
Orphaneti819. Smith-Magenis syndrome.
PharmGKBiPA28171.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0444. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000016110.
HOVERGENiHBG051627.
InParanoidiQ13045.
OMAiQMKADLT.
OrthoDBiEOG091G00R0.
PhylomeDBiQ13045.
TreeFamiTF313468.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177731-MONOMER.
SIGNORiQ13045.

Miscellaneous databases

ChiTaRSiFLII. human.
GeneWikiiFLII.
GenomeRNAii2314.
PROiQ13045.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177731.
CleanExiHS_FLII.
ExpressionAtlasiQ13045. baseline and differential.
GenevisibleiQ13045. HS.

Family and domain databases

Gene3Di3.40.20.10. 7 hits.
3.80.10.10. 3 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR029919. FliI.
IPR007123. Gelsolin-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF42. PTHR11977:SF42. 1 hit.
PfamiPF00626. Gelsolin. 4 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLII_HUMAN
AccessioniPrimary (citable) accession number: Q13045
Secondary accession number(s): B4DIL0, F5H407, J3QLG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 172 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.