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Protein

Striatin-3

Gene

STRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

GO - Molecular functioni

  • armadillo repeat domain binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB
  • protein complex binding Source: UniProtKB
  • protein phosphatase 2A binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

SignaLinkiQ13033.

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-3
Alternative name(s):
Cell cycle autoantigen SG2NA
S/G2 antigen
Gene namesi
Name:STRN3
Synonyms:GS2NA, SG2NA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15720. STRN3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • neuronal cell body Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38394.

Polymorphism and mutation databases

BioMutaiSTRN3.
DMDMi223634717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 797797Striatin-3PRO_0000051236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei150 – 1501PhosphothreonineBy similarity
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei214 – 2141PhosphoserineCombined sources
Modified residuei229 – 2291PhosphoserineCombined sources
Modified residuei257 – 2571PhosphoserineCombined sources
Modified residuei335 – 3351PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13033.
MaxQBiQ13033.
PaxDbiQ13033.
PeptideAtlasiQ13033.
PRIDEiQ13033.

PTM databases

iPTMnetiQ13033.
PhosphoSiteiQ13033.

Expressioni

Gene expression databases

BgeeiENSG00000196792.
CleanExiHS_STRN3.
ExpressionAtlasiQ13033. baseline and differential.
GenevisibleiQ13033. HS.

Organism-specific databases

HPAiHPA003392.
HPA004636.

Interactioni

Subunit structurei

Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB (PubMed:25743393).Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CTTNBP2NLQ9P2B48EBI-1053857,EBI-1774273
STRNO438159EBI-1053857,EBI-1046642
TRAF3IP3Q9Y2282EBI-1053857,EBI-765817

GO - Molecular functioni

  • armadillo repeat domain binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB
  • protein complex binding Source: UniProtKB
  • protein phosphatase 2A binding Source: UniProtKB

Protein-protein interaction databases

BioGridi118999. 82 interactions.
IntActiQ13033. 61 interactions.
MINTiMINT-121972.
STRINGi9606.ENSP00000350071.

Structurei

Secondary structure

1
797
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi86 – 12944Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4N6JX-ray2.00A/B86-131[»]
ProteinModelPortaliQ13033.
SMRiQ13033. Positions 86-130, 442-796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati478 – 51740WD 1Add
BLAST
Repeati531 – 57040WD 2Add
BLAST
Repeati584 – 62340WD 3Add
BLAST
Repeati679 – 71840WD 4Add
BLAST
Repeati721 – 76040WD 5Add
BLAST
Repeati767 – 79630WD 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni71 – 799Caveolin-bindingSequence analysis
Regioni166 – 18318Calmodulin-bindingSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili77 – 13660Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 138Poly-Gly

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiQ13033.
KOiK17608.
OMAiDDTDVKM.
OrthoDBiEOG091G0509.
PhylomeDBiQ13033.
TreeFamiTF313387.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Beta (identifier: Q13033-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDELAGGGGG GPGMAAPPRQ QQGPGGNLGL SPGGNGAAGG GGPPASEGAG
60 70 80 90 100
PAAGPELSRP QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL
110 120 130 140 150
QGERKGQENL KKDLVRRIKM LEYALKQERA KYHKLKYGTE LNQGDLKMPT
160 170 180 190 200
FESEETKDTE APTAPQNSQL TWKQGRQLLR QYLQEVGYTD TILDVRSQRV
210 220 230 240 250
RSLLGLSNSE PNGSVETKNL EQILNGGESP KQKGQEIKRS SGDVLETFNF
260 270 280 290 300
LENADDSDED EENDMIEGIP EGKDKHRMNK HKIGNEGLAA DLTDDPDTEE
310 320 330 340 350
ALKEFDFLVT AEDGEGAGEA RSSGDGTEWD KDDLSPTAEV WDVDQGLISK
360 370 380 390 400
LKEQYKKERK GKKGVKRANR TKLYDMIADL GDDELPHIPS GIINQSRSAS
410 420 430 440 450
TRMTDHEGAR AEEAEPITFP SGGGKSFIMG SDDVLLSVLG LGDLADLTVT
460 470 480 490 500
NDADYSYDLP ANKDAFRKTW NPKYTLRSHF DGVRALAFHP VEPVLVTASE
510 520 530 540 550
DHTLKLWNLQ KTVPAKKSAS LDVEPIYTFR AHIGPVLSLA ISSNGEQCFS
560 570 580 590 600
GGIDATIQWW NMPSPSVDPY DTYEPNVLAG TLVGHTDAVW GLAYSGIKNQ
610 620 630 640 650
LLSCSADGTV RLWNPQEKLP CICTYNGDKK HGIPTSVDFI GCDPAHMVTS
660 670 680 690 700
FNTGSAVIYD LETSQSLVIL SSQVDSGLQS NNHINRVVSH PTLPVTITAH
710 720 730 740 750
EDRHIKFFDN KTGKMIHSMV AHLDAVTSLA VDPNGIYLMS GSHDCSIRLW
760 770 780 790
NLDSKTCVQE ITAHRKKLDE SIYDVAFHSS KAYIASAGAD ALAKVFV
Length:797
Mass (Da):87,209
Last modified:February 10, 2009 - v3
Checksum:i2179BD257186DFB0
GO
Isoform Alpha (identifier: Q13033-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-413: Missing.

Show »
Length:713
Mass (Da):77,745
Checksum:i8252FEA677586912
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631Y → N in AAB81551 (PubMed:7864889).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti471 – 4711N → S.2 Publications
Corresponds to variant rs2273171 [ dbSNP | Ensembl ].
VAR_054337

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei330 – 41384Missing in isoform Alpha. 3 PublicationsVSP_006786Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17989 mRNA. Translation: AAB81551.1.
AK314041 mRNA. Translation: BAG36750.1.
AL049830 Genomic DNA. No translation available.
BC132673 mRNA. Translation: AAI32674.1.
AF243424 mRNA. Translation: AAF81201.1.
CCDSiCCDS41938.1. [Q13033-1]
CCDS9641.1. [Q13033-2]
PIRiJC2522.
RefSeqiNP_001077362.1. NM_001083893.1. [Q13033-1]
NP_055389.3. NM_014574.3. [Q13033-2]
UniGeneiHs.401843.

Genome annotation databases

EnsembliENST00000355683; ENSP00000347909; ENSG00000196792. [Q13033-2]
ENST00000357479; ENSP00000350071; ENSG00000196792. [Q13033-1]
GeneIDi29966.
KEGGihsa:29966.
UCSCiuc001wqu.3. human. [Q13033-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17989 mRNA. Translation: AAB81551.1.
AK314041 mRNA. Translation: BAG36750.1.
AL049830 Genomic DNA. No translation available.
BC132673 mRNA. Translation: AAI32674.1.
AF243424 mRNA. Translation: AAF81201.1.
CCDSiCCDS41938.1. [Q13033-1]
CCDS9641.1. [Q13033-2]
PIRiJC2522.
RefSeqiNP_001077362.1. NM_001083893.1. [Q13033-1]
NP_055389.3. NM_014574.3. [Q13033-2]
UniGeneiHs.401843.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4N6JX-ray2.00A/B86-131[»]
ProteinModelPortaliQ13033.
SMRiQ13033. Positions 86-130, 442-796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118999. 82 interactions.
IntActiQ13033. 61 interactions.
MINTiMINT-121972.
STRINGi9606.ENSP00000350071.

PTM databases

iPTMnetiQ13033.
PhosphoSiteiQ13033.

Polymorphism and mutation databases

BioMutaiSTRN3.
DMDMi223634717.

Proteomic databases

EPDiQ13033.
MaxQBiQ13033.
PaxDbiQ13033.
PeptideAtlasiQ13033.
PRIDEiQ13033.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355683; ENSP00000347909; ENSG00000196792. [Q13033-2]
ENST00000357479; ENSP00000350071; ENSG00000196792. [Q13033-1]
GeneIDi29966.
KEGGihsa:29966.
UCSCiuc001wqu.3. human. [Q13033-1]

Organism-specific databases

CTDi29966.
GeneCardsiSTRN3.
H-InvDBHIX0037669.
HGNCiHGNC:15720. STRN3.
HPAiHPA003392.
HPA004636.
MIMi614766. gene.
neXtProtiNX_Q13033.
PharmGKBiPA38394.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiQ13033.
KOiK17608.
OMAiDDTDVKM.
OrthoDBiEOG091G0509.
PhylomeDBiQ13033.
TreeFamiTF313387.

Enzyme and pathway databases

SignaLinkiQ13033.

Miscellaneous databases

ChiTaRSiSTRN3. human.
GeneWikiiSTRN3.
GenomeRNAii29966.
PROiQ13033.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196792.
CleanExiHS_STRN3.
ExpressionAtlasiQ13033. baseline and differential.
GenevisibleiQ13033. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTRN3_HUMAN
AccessioniPrimary (citable) accession number: Q13033
Secondary accession number(s): A2RTX7, A6NHZ7, Q9NRA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 169 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be nuclear.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.