Reviewed,
UniProtKB/Swiss-Prot Q13033 (STRN3_HUMAN)
Last modified
November 25, 2008.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Striatin-3 Alternative name(s): Cell-cycle autoantigen SG2NA S/G2 antigen | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 797 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. |
| Subunit structure | Interacts with protein phosphatase 2A (PP2A) Potential. |
| Subcellular location | CytoplasmBy similarity. Membrane; Peripheral membrane proteinBy similarity. |
| Sequence similarities | Belongs to the WD repeat striatin family. Contains 6 WD repeats. |
| Caution | Was originally (Ref.1) thought to be nuclear. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil Repeat WD repeat |
| Ligand | Calmodulin-binding |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from direct assay. Source: UniProtKB |
| Cellular component | cytoskeleton Inferred from direct assay. Source: HPA cytosol Ref.2Non-traceable author statement. Source: UniProtKB membraneInferred from electronic annotation. Source: UniProtKB-KW membrane fraction Ref.2Non-traceable author statement. Source: UniProtKB nucleusInferred from direct assay. Source: UniProtKB |
| Molecular function | calmodulin binding Ref.2 Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| MCC | P23508 | 1 | EBI-1053857,EBI-307531 | |
| STK24 | Q5T5B3 | 1 | EBI-1053857,EBI-1054809 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] Notes: Additional isoforms seem to exist. | ||||||
| Isoform Beta (identifier: Q13033-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Alpha (identifier: Q13033-2) The sequence of this isoform differs from the canonical sequence as follows: 330-413: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 797 | 797 | Striatin-3 | PRO_0000051236 | |||||
Regions | |||||||||
| Repeat | 478 – 517 | 40 | WD 1 | ||||||
| Repeat | 531 – 570 | 40 | WD 2 | ||||||
| Repeat | 584 – 623 | 40 | WD 3 | ||||||
| Repeat | 679 – 718 | 40 | WD 4 | ||||||
| Repeat | 721 – 760 | 40 | WD 5 | ||||||
| Repeat | 767 – 796 | 30 | WD 6 | ||||||
| Region | 71 – 79 | 9 | Caveolin-binding Potential | ||||||
| Region | 166 – 183 | 18 | Calmodulin-binding Potential | ||||||
| Coiled coil | 77 – 136 | 60 | Potential | ||||||
| Compositional bias | 6 – 13 | 8 | Poly-Gly | ||||||
Amino acid modifications | |||||||||
| Modified residue | 229 | 1 | Phosphoserine | ||||||
| Modified residue | 257 | 1 | Phosphoserine | ||||||
Natural variations | |||||||||
| Alternative sequence | 330 – 413 | 84 | Missing in isoform Alpha. | VSP_006786 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells." Muro Y., Chan E.K., Landberg G., Tan E.M. Biochem. Biophys. Res. Commun. 207:1029-1037(1995) [PubMed: 7864889] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA). Tissue: Liver. |
| [2] | "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain." Castets F., Rakitina T., Gaillard S., Moqrich A., Mattei M.-G., Monneron A. J. Biol. Chem. 275:19970-19977(2000) [PubMed: 10748158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 120-797 (ISOFORM BETA). |
| [3] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, MASS SPECTROMETRY. Tissue: Epithelium. |
| [4] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, MASS SPECTROMETRY. Tissue: Epithelium. |
| [5] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, MASS SPECTROMETRY. |
| [6] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229 AND SER-257, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| U17989 mRNA. Translation: AAB81551.1. AF243424 mRNA. Translation: AAF81201.1. | |
| PIR | JC2522. |
| UniGene | Hs.401843 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q13033. |
PTM databases | |
| PhosphoSite | Q13033. |
Genome annotation databases | |
| Ensembl | ENSG00000196792. Homo sapiens. [Contig view] |
Organism-specific databases | |
| H-InvDB | HIX0037669. |
| HGNC | HGNC:15720. STRN3. |
| HPA | HPA003392. HPA004636. |
| PharmGKB | PA38394. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q13033. |
| HOVERGEN | Q13033. |
Gene expression databases | |
| ArrayExpress | Q13033. |
| CleanEx | HS_STRN3. |
| GermOnline | ENSG00000196792. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013258. Striatin_N. IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. [Graphical view] |
| Gene3D | G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit. |
| Pfam | PF08232. Striatin. 1 hit. PF00400. WD40. 4 hits. [Graphical view] |
| PRINTS | PR00320. GPROTEINBRPT. |
| ProDom | PD000018. WD40. 2 hits. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00320. WD40. 7 hits. [Graphical view] |
| PROSITE | PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | STRN3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13033 Secondary accession number(s): Q9NRA5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


