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Reviewed, UniProtKB/Swiss-Prot Q13023 (AKAP6_HUMAN)

Last modified November 25, 2008. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    A-kinase anchor protein 6
Alternative name(s):
    Protein kinase A-anchoring protein 6
      Short name=PRKA6
    A-kinase anchor protein 100 kDa
      Short name=AKAP 100
    mAKAP
Gene names
Name: AKAP6
Synonyms: AKAP100, KIAA0311
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length2319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

Subunit structure

Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79.

Subcellular location

Sarcoplasmic reticulum. Nucleus membrane. Note= In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.

Tissue specificity

Highly expressed in cardiac and skeletal muscle, followed by brain.

Domain

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Sequence similarities

Contains 2 spectrin repeats.

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Ontologies

Keywords

   Cellular componentMembrane
Nucleus
Sarcoplasmic reticulum
   Coding sequence diversityPolymorphism
   DomainRepeat

Gene Ontology (GO)

   Biological processprotein targeting Ref.1 Ref.4

Non-traceable author statement. Source: UniProtKB

   Cellular componentnuclear membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

sarcoplasmic reticulum Ref.4

Inferred from direct assay. Source: UniProtKB

   Molecular functionprotein kinase A binding Ref.1

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23192319A-kinase anchor protein 6
PRO_0000064530

Regions

Repeat762 – 84887Spectrin 1
Repeat1036 – 1150115Spectrin 2
Region2063 – 207614PKA-RII subunit binding domain
Compositional bias1560 – 1701142Ser-rich

Natural variations

Natural variant3371A → V: dbSNP rs3742926.
VAR_028171
Natural variant4081N → S: dbSNP rs17099240.
VAR_028172
Natural variant9101K → M in a breast cancer sample; somatic mutation.
VAR_035781
Natural variant11921M → I in a breast cancer sample; somatic mutation.
VAR_035782
Natural variant14921A → V: dbSNP rs11845640.
VAR_028173
Natural variant17021E → Q in a breast cancer sample; somatic mutation.
VAR_035783
Natural variant18391P → T in a colorectal cancer sample; somatic mutation.
VAR_035784
Natural variant20351N → D: dbSNP rs1051695.
VAR_028174
Natural variant21711F → Y: dbSNP rs4647899.
VAR_028175
Natural variant22091D → H: dbSNP rs4402458.
VAR_028176

Experimental info

Sequence conflict9741W → C in AAA92354. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q13023-1 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 7607B71AD2140727

FASTA2,319256,720
        10         20         30         40         50         60 
MLTMSVTLSP LRSQDLDPMA TDASPMAINM TPTVEQGEGE EAMKDMDSDQ QYEKPPPLHT 

        70         80         90        100        110        120 
GADWKIVLHL PEIETWLRMT SERVRDLTYS VQQDSDSKHV DVHLVQLKDI CEDISDHVEQ 

       130        140        150        160        170        180 
IHALLETEFS LKLLSYSVNV IVDIHAVQLL WHQLRVSVLV LRERILQGLQ DANGNYTRQT 

       190        200        210        220        230        240 
DILQAFSEET KEGRLDSLTE VDDSGQLTIK CSQNYLSLDC GITAFELSDY SPSEDLLSGL 

       250        260        270        280        290        300 
GDMTSSQVKT KPFDSWSYSE MEKEFPELIR SVGLLTVAAD SISTNGSEAV TEEVSQVSLS 

       310        320        330        340        350        360 
VDDKGGCEED NASAVEEQPG LTLGVSSSSG EALTNAAQPS SETVQQESSS SSHHDAKNQQ 

       370        380        390        400        410        420 
PVPCENATPK RTIRDCFNYN EDSPTQPTLP KRGLFLKEET FKNDLKGNGG KRQMVDLKPE 

       430        440        450        460        470        480 
MSRSTPSLVD PPDRSKLCLV LQSSYPNSPS AASQSYECLH KVGNGNLENT VKFHIKEISS 

       490        500        510        520        530        540 
SLGRLNDCYK EKSRLKKPHK TSEEVPPCRT PKRGTGSGKQ AKNTKSSAVP NGELSYTSKA 

       550        560        570        580        590        600 
IEGPQTNSAS TSSLEPCNQR SWNAKLQLQS ETSSSPAFTQ SSESSVGSDN IMSPVPLLSK 

       610        620        630        640        650        660 
HKSKKGQASS PSHVTRNGEV VEAWYGSDEY LALPSHLKQT EVLALKLENL TKLLPQKPRG 

       670        680        690        700        710        720 
ETIQNIDDWE LSEMNSDSEI YPTYHVKKKH TRLGRVSPSS SSDIASSLGE SIESGPLSDI 

       730        740        750        760        770        780 
LSDEESSMPL AGMKKYADEK SERASSSEKN ESHSATKSAL IQKLMQDIQH QDNYEAIWEK 

       790        800        810        820        830        840 
IEGFVNKLDE FIQWLNEAME TTENWTPPKA EMDDLKLYLE THLSFKLNVD SHCALKEAVE 

       850        860        870        880        890        900 
EEGHQLLELI ASHKAGLKDM LRMIASQWKE LQRQIKRQHS WILRALDTIK AEILATDVSV 

       910        920        930        940        950        960 
EDEEGTGSPK AEVQLCYLEA QRDAVEQMSL KLYSEQYTSS SKRKEEFADM SKVHSVGSNG 

       970        980        990       1000       1010       1020 
LLDFDSEYQE LWDWLIDMES LVMDSHDLMM SEEQQQHLYK RYSVEMSIRH LKKTELLSKV 

      1030       1040       1050       1060       1070       1080 
EALKKGGVLL PNDLLEKVDS INEKWELLGK TLGEKIQDTM AGHSGSSPRD LLSPESGSLV 

      1090       1100       1110       1120       1130       1140 
RQLEVRIKEL KGWLRDTELF IFNSCLRQEK EGTMNTEKQL QYFKSLCREI KQRRRGVASI 

      1150       1160       1170       1180       1190       1200 
LRLCQHLLDD RETCNLNADH QPMQLIIVNL ERRWEAIVMQ AVQWQTRLQK KMGKESETLN 

      1210       1220       1230       1240       1250       1260 
VIDPGLMDLN GMSEDALEWD EMDISNKLIS LNEESNDLDQ ELQPVIPSLK LGETSNEDPG 

      1270       1280       1290       1300       1310       1320 
YDEEADNHGG SQYASNITAP SSPHIYQVYS LHNVELYEDN HMPFLKNNPK VTGMTQPNVL 

      1330       1340       1350       1360       1370       1380 
TKSLSKDSSF SSTKSLPDLL GGSNLVKPCA CHGGDMSQNS GSESGIVSEG DTETTTNSEM 

      1390       1400       1410       1420       1430       1440 
CLLNAVDGSP SNLETEHLDP QMGDAVNVLK QKFTDEGESI KLPNSSQSSI SPVGCVNGKV 

      1450       1460       1470       1480       1490       1500 
GDLNSITKHT PDCLGEELQG KHDVFTFYDY SYLQGSKLKL PMIMKQSQSE KAHVEDPLLR 

      1510       1520       1530       1540       1550       1560 
GFYFDKKSCK SKHQTTELQP DVPPHERILA SASHEMDRIS YKSGNIEKTF TGMQNAKQLS 

      1570       1580       1590       1600       1610       1620 
LLSHSSSIES LSPGGDLFGL GIFKNGSDSL QRSTSLESWL TSYKSNEDLF SCHSSGDISV 

      1630       1640       1650       1660       1670       1680 
SSGSVGELSK RTLDLLNRLE NIQSPSEQKI KRSVSDITLQ SSSQKMSFTG QMSLDIASSI 

      1690       1700       1710       1720       1730       1740 
NEDSAASLTE LSSSDELSLC SEDIVLHKNK IPESNASFRK RLTRSVADES DVNVSMIVNV 

      1750       1760       1770       1780       1790       1800 
SCTSACTDDE DDSDLLSSST LTLTEEELCI KDEDDDSSIA TDDEIYEDCT LMSGLDYIKN 

      1810       1820       1830       1840       1850       1860 
ELQTWIRPKL SLTRDKKRCN VSDEMKGSKD ISSSEMTNPS DTLNIETLLN GSVKRVSENN 

      1870       1880       1890       1900       1910       1920 
GNGKNSSHTH ELGTKRENKK TIFKVNKDPY VADMENGNIE GIPERQKGKP NVTSKVSENL 

      1930       1940       1950       1960       1970       1980 
GSHGKEISES EHCKCKALMD SLDDSNTAGK EFVSQDVRHL PKKCPNHHHF ENQSTASTPT 

      1990       2000       2010       2020       2030       2040 
EKSFSELALE TRFNNRQDSD ALKSSDDAPS MAGKSAGCCL ALEQNGTEEN ASISNISCCN 

      2050       2060       2070       2080       2090       2100 
CEPDVFHQKD AEDCSVHNFV KEIIDMASTA LKSKSQPENE VAAPTSLTQI KEKVLEHSHR 

      2110       2120       2130       2140       2150       2160 
PIQLRKGDFY SYLSLSSHDS DCGEVTNYIE EKSSTPLPLD TTDSGLDDKE DIECFFEACV 

      2170       2180       2190       2200       2210       2220 
EGDSDGEEPC FSSAPPNESA VPSEAAMPLQ ATACSSEFSD SSLSADDADT VALSSPSSQE 

      2230       2240       2250       2260       2270       2280 
RAEVGKEVNG LPQTSSGCAE NLEFTPSKLD SEKESSGKPG ESGMPEEHNA ASAKSKVQDL 

      2290       2300       2310 
SLKANQPTDK AALHPSPKTL TCEENLLNLH EKRHRNMHR

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References

« Hide 'large scale' references
[1]"mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes."
Kapiloff M.S., Shillace R.V., Westphal A.M., Scott J.D.
J. Cell Sci. 112:2725-2736(1999) [PubMed: 10413680] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-1492.
[2]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum."
McCartney S., Little B.M., Langeberg L.K., Scott J.D.
J. Biol. Chem. 270:9327-9333(1995) [PubMed: 7721854] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1666-2319.
Tissue: Hippocampus.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-910; ILE-1192; GLN-1702 AND THR-1839.

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Cross-references

Sequence databases

U17195 mRNA. Translation: AAA92354.2.
AB002309 mRNA. Translation: BAA20770.2. Different initiation.
RefSeqNP_004265.3.
UniGeneHs.509083

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ13023.

PTM databases

PhosphoSiteQ13023.

Genome annotation databases

EnsemblENSG00000151320. Homo sapiens. [Contig view]
GeneID9472.
KEGGhsa:9472.

Organism-specific databases

H-InvDBHIX0011586.
HGNCHGNC:376. AKAP6.
HPACAB001983.
MIM604691. gene.
PharmGKBPA24670.
HUGESearch...
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ13023.
HOVERGENQ13023.

Gene expression databases

ArrayExpressQ13023.
CleanExHS_AKAP6.

Family and domain databases

InterProIPR002017. Spectrin_repeat.
[Graphical view]
SMARTSM00150. SPEC. 3 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio35494.
SOURCESearch...

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Entry information

Entry nameAKAP6_HUMAN
AccessionPrimary (citable) accession number: Q13023
Secondary accession number(s): O15028
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: November 25, 2008
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents