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Q13023

- AKAP6_HUMAN

UniProt

Q13023 - AKAP6_HUMAN

Protein

A-kinase anchor protein 6

Gene

AKAP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

    GO - Molecular functioni

    1. adenylate cyclase binding Source: BHF-UCL
    2. ion channel binding Source: BHF-UCL
    3. protein anchor Source: BHF-UCL
    4. protein binding Source: UniProtKB
    5. protein complex scaffold Source: BHF-UCL
    6. protein kinase A binding Source: UniProtKB
    7. protein kinase A regulatory subunit binding Source: BHF-UCL

    GO - Biological processi

    1. action potential Source: BHF-UCL
    2. cAMP-mediated signaling Source: BHF-UCL
    3. cellular response to cAMP Source: BHF-UCL
    4. cellular response to cytokine stimulus Source: BHF-UCL
    5. negative regulation of cAMP biosynthetic process Source: BHF-UCL
    6. positive regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
    7. positive regulation of cell growth Source: BHF-UCL
    8. positive regulation of cell growth involved in cardiac muscle cell development Source: BHF-UCL
    9. positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
    10. positive regulation of NFAT protein import into nucleus Source: BHF-UCL
    11. positive regulation of potassium ion transmembrane transport Source: BHF-UCL
    12. positive regulation of protein phosphatase type 2B activity Source: BHF-UCL
    13. positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
    14. positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
    15. protein targeting Source: UniProtKB
    16. regulation of membrane repolarization Source: BHF-UCL
    17. regulation of protein kinase A signaling Source: BHF-UCL
    18. regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A-kinase anchor protein 6
    Short name:
    AKAP-6
    Alternative name(s):
    A-kinase anchor protein 100 kDa
    Short name:
    AKAP 100
    Protein kinase A-anchoring protein 6
    Short name:
    PRKA6
    mAKAP
    Gene namesi
    Name:AKAP6
    Synonyms:AKAP100, KIAA0311
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:376. AKAP6.

    Subcellular locationi

    Sarcoplasmic reticulum. Nucleus membrane
    Note: In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.

    GO - Cellular componenti

    1. calcium channel complex Source: BHF-UCL
    2. caveola Source: BHF-UCL
    3. cytoplasm Source: BHF-UCL
    4. intercalated disc Source: BHF-UCL
    5. junctional sarcoplasmic reticulum membrane Source: BHF-UCL
    6. nuclear envelope Source: UniProtKB
    7. nuclear membrane Source: UniProtKB-SubCell
    8. perinuclear region of cytoplasm Source: BHF-UCL
    9. sarcoplasmic reticulum Source: UniProtKB
    10. T-tubule Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane, Nucleus, Sarcoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24670.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23192319A-kinase anchor protein 6PRO_0000064530Add
    BLAST

    Proteomic databases

    PaxDbiQ13023.
    PRIDEiQ13023.

    PTM databases

    PhosphoSiteiQ13023.

    Expressioni

    Tissue specificityi

    Highly expressed in cardiac and skeletal muscle, followed by brain.

    Gene expression databases

    ArrayExpressiQ13023.
    BgeeiQ13023.
    CleanExiHS_AKAP6.
    GenevestigatoriQ13023.

    Organism-specific databases

    HPAiCAB001983.

    Interactioni

    Subunit structurei

    Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    OPTNQ96CV92EBI-1056102,EBI-748974

    Protein-protein interaction databases

    BioGridi114857. 10 interactions.
    IntActiQ13023. 11 interactions.
    STRINGi9606.ENSP00000280979.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13023.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati762 – 84887Spectrin 1Add
    BLAST
    Repeati1036 – 1150115Spectrin 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2063 – 207614PKA-RII subunit binding domainAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1560 – 1701142Ser-richAdd
    BLAST

    Domaini

    RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

    Sequence similaritiesi

    Contains 2 spectrin repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG119013.
    HOGENOMiHOG000001568.
    HOVERGENiHBG050480.
    InParanoidiQ13023.
    KOiK16523.
    OMAiNGSDSLQ.
    OrthoDBiEOG71G9T4.
    PhylomeDBiQ13023.
    TreeFamiTF105405.

    Family and domain databases

    InterProiIPR026696. AKAP6/CEP68.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    [Graphical view]
    PANTHERiPTHR14514. PTHR14514. 1 hit.
    PfamiPF00435. Spectrin. 1 hit.
    [Graphical view]
    SMARTiSM00150. SPEC. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13023-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTMSVTLSP LRSQDLDPMA TDASPMAINM TPTVEQGEGE EAMKDMDSDQ     50
    QYEKPPPLHT GADWKIVLHL PEIETWLRMT SERVRDLTYS VQQDSDSKHV 100
    DVHLVQLKDI CEDISDHVEQ IHALLETEFS LKLLSYSVNV IVDIHAVQLL 150
    WHQLRVSVLV LRERILQGLQ DANGNYTRQT DILQAFSEET KEGRLDSLTE 200
    VDDSGQLTIK CSQNYLSLDC GITAFELSDY SPSEDLLSGL GDMTSSQVKT 250
    KPFDSWSYSE MEKEFPELIR SVGLLTVAAD SISTNGSEAV TEEVSQVSLS 300
    VDDKGGCEED NASAVEEQPG LTLGVSSSSG EALTNAAQPS SETVQQESSS 350
    SSHHDAKNQQ PVPCENATPK RTIRDCFNYN EDSPTQPTLP KRGLFLKEET 400
    FKNDLKGNGG KRQMVDLKPE MSRSTPSLVD PPDRSKLCLV LQSSYPNSPS 450
    AASQSYECLH KVGNGNLENT VKFHIKEISS SLGRLNDCYK EKSRLKKPHK 500
    TSEEVPPCRT PKRGTGSGKQ AKNTKSSAVP NGELSYTSKA IEGPQTNSAS 550
    TSSLEPCNQR SWNAKLQLQS ETSSSPAFTQ SSESSVGSDN IMSPVPLLSK 600
    HKSKKGQASS PSHVTRNGEV VEAWYGSDEY LALPSHLKQT EVLALKLENL 650
    TKLLPQKPRG ETIQNIDDWE LSEMNSDSEI YPTYHVKKKH TRLGRVSPSS 700
    SSDIASSLGE SIESGPLSDI LSDEESSMPL AGMKKYADEK SERASSSEKN 750
    ESHSATKSAL IQKLMQDIQH QDNYEAIWEK IEGFVNKLDE FIQWLNEAME 800
    TTENWTPPKA EMDDLKLYLE THLSFKLNVD SHCALKEAVE EEGHQLLELI 850
    ASHKAGLKDM LRMIASQWKE LQRQIKRQHS WILRALDTIK AEILATDVSV 900
    EDEEGTGSPK AEVQLCYLEA QRDAVEQMSL KLYSEQYTSS SKRKEEFADM 950
    SKVHSVGSNG LLDFDSEYQE LWDWLIDMES LVMDSHDLMM SEEQQQHLYK 1000
    RYSVEMSIRH LKKTELLSKV EALKKGGVLL PNDLLEKVDS INEKWELLGK 1050
    TLGEKIQDTM AGHSGSSPRD LLSPESGSLV RQLEVRIKEL KGWLRDTELF 1100
    IFNSCLRQEK EGTMNTEKQL QYFKSLCREI KQRRRGVASI LRLCQHLLDD 1150
    RETCNLNADH QPMQLIIVNL ERRWEAIVMQ AVQWQTRLQK KMGKESETLN 1200
    VIDPGLMDLN GMSEDALEWD EMDISNKLIS LNEESNDLDQ ELQPVIPSLK 1250
    LGETSNEDPG YDEEADNHGG SQYASNITAP SSPHIYQVYS LHNVELYEDN 1300
    HMPFLKNNPK VTGMTQPNVL TKSLSKDSSF SSTKSLPDLL GGSNLVKPCA 1350
    CHGGDMSQNS GSESGIVSEG DTETTTNSEM CLLNAVDGSP SNLETEHLDP 1400
    QMGDAVNVLK QKFTDEGESI KLPNSSQSSI SPVGCVNGKV GDLNSITKHT 1450
    PDCLGEELQG KHDVFTFYDY SYLQGSKLKL PMIMKQSQSE KAHVEDPLLR 1500
    GFYFDKKSCK SKHQTTELQP DVPPHERILA SASHEMDRIS YKSGNIEKTF 1550
    TGMQNAKQLS LLSHSSSIES LSPGGDLFGL GIFKNGSDSL QRSTSLESWL 1600
    TSYKSNEDLF SCHSSGDISV SSGSVGELSK RTLDLLNRLE NIQSPSEQKI 1650
    KRSVSDITLQ SSSQKMSFTG QMSLDIASSI NEDSAASLTE LSSSDELSLC 1700
    SEDIVLHKNK IPESNASFRK RLTRSVADES DVNVSMIVNV SCTSACTDDE 1750
    DDSDLLSSST LTLTEEELCI KDEDDDSSIA TDDEIYEDCT LMSGLDYIKN 1800
    ELQTWIRPKL SLTRDKKRCN VSDEMKGSKD ISSSEMTNPS DTLNIETLLN 1850
    GSVKRVSENN GNGKNSSHTH ELGTKRENKK TIFKVNKDPY VADMENGNIE 1900
    GIPERQKGKP NVTSKVSENL GSHGKEISES EHCKCKALMD SLDDSNTAGK 1950
    EFVSQDVRHL PKKCPNHHHF ENQSTASTPT EKSFSELALE TRFNNRQDSD 2000
    ALKSSDDAPS MAGKSAGCCL ALEQNGTEEN ASISNISCCN CEPDVFHQKD 2050
    AEDCSVHNFV KEIIDMASTA LKSKSQPENE VAAPTSLTQI KEKVLEHSHR 2100
    PIQLRKGDFY SYLSLSSHDS DCGEVTNYIE EKSSTPLPLD TTDSGLDDKE 2150
    DIECFFEACV EGDSDGEEPC FSSAPPNESA VPSEAAMPLQ ATACSSEFSD 2200
    SSLSADDADT VALSSPSSQE RAEVGKEVNG LPQTSSGCAE NLEFTPSKLD 2250
    SEKESSGKPG ESGMPEEHNA ASAKSKVQDL SLKANQPTDK AALHPSPKTL 2300
    TCEENLLNLH EKRHRNMHR 2319
    Length:2,319
    Mass (Da):256,720
    Last modified:October 17, 2006 - v3
    Checksum:i7607B71AD2140727
    GO
    Isoform 2 (identifier: Q13023-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1050-1075: KTLGEKIQDTMAGHSGSSPRDLLSPE → VFAFLLLFVGYVYIFCVVKYSVRFLI
         1076-2319: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,075
    Mass (Da):120,243
    Checksum:i813200266D867C38
    GO

    Sequence cautioni

    The sequence BAA20770.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti974 – 9741W → C in AAA92354. (PubMed:10413680)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti337 – 3371A → V.
    Corresponds to variant rs3742926 [ dbSNP | Ensembl ].
    VAR_028171
    Natural varianti408 – 4081N → S.
    Corresponds to variant rs17099240 [ dbSNP | Ensembl ].
    VAR_028172
    Natural varianti558 – 5581N → D.
    Corresponds to variant rs35210906 [ dbSNP | Ensembl ].
    VAR_050653
    Natural varianti892 – 8921E → K.
    Corresponds to variant rs34572259 [ dbSNP | Ensembl ].
    VAR_050654
    Natural varianti910 – 9101K → M in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035781
    Natural varianti1192 – 11921M → I in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035782
    Natural varianti1492 – 14921A → V.1 Publication
    Corresponds to variant rs11845640 [ dbSNP | Ensembl ].
    VAR_028173
    Natural varianti1516 – 15161T → A.
    Corresponds to variant rs17099587 [ dbSNP | Ensembl ].
    VAR_050655
    Natural varianti1522 – 15221V → I.
    Corresponds to variant rs34711402 [ dbSNP | Ensembl ].
    VAR_050656
    Natural varianti1702 – 17021E → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035783
    Natural varianti1839 – 18391P → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035784
    Natural varianti2035 – 20351N → D.
    Corresponds to variant rs1051695 [ dbSNP | Ensembl ].
    VAR_028174
    Natural varianti2171 – 21711F → Y.
    Corresponds to variant rs4647899 [ dbSNP | Ensembl ].
    VAR_028175
    Natural varianti2209 – 22091D → H.
    Corresponds to variant rs4402458 [ dbSNP | Ensembl ].
    VAR_028176
    Natural varianti2267 – 22671E → D.
    Corresponds to variant rs35977369 [ dbSNP | Ensembl ].
    VAR_050657

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1050 – 107526KTLGE…LLSPE → VFAFLLLFVGYVYIFCVVKY SVRFLI in isoform 2. 1 PublicationVSP_054497Add
    BLAST
    Alternative sequencei1076 – 23191244Missing in isoform 2. 1 PublicationVSP_054498Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17195 mRNA. Translation: AAA92354.2.
    AB002309 mRNA. Translation: BAA20770.2. Different initiation.
    AL049781 Genomic DNA. No translation available.
    AL117672 Genomic DNA. No translation available.
    AL132988 Genomic DNA. No translation available.
    AL136298 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65931.1.
    BC150185 mRNA. Translation: AAI50186.1.
    BC150288 mRNA. Translation: AAI50289.1.
    BC154413 mRNA. Translation: AAI54414.1.
    CCDSiCCDS9644.1. [Q13023-1]
    RefSeqiNP_004265.3. NM_004274.4. [Q13023-1]
    UniGeneiHs.509083.

    Genome annotation databases

    EnsembliENST00000280979; ENSP00000280979; ENSG00000151320. [Q13023-1]
    ENST00000557354; ENSP00000450531; ENSG00000151320. [Q13023-2]
    GeneIDi9472.
    KEGGihsa:9472.
    UCSCiuc001wrq.3. human. [Q13023-1]

    Polymorphism databases

    DMDMi116241243.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17195 mRNA. Translation: AAA92354.2 .
    AB002309 mRNA. Translation: BAA20770.2 . Different initiation.
    AL049781 Genomic DNA. No translation available.
    AL117672 Genomic DNA. No translation available.
    AL132988 Genomic DNA. No translation available.
    AL136298 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65931.1 .
    BC150185 mRNA. Translation: AAI50186.1 .
    BC150288 mRNA. Translation: AAI50289.1 .
    BC154413 mRNA. Translation: AAI54414.1 .
    CCDSi CCDS9644.1. [Q13023-1 ]
    RefSeqi NP_004265.3. NM_004274.4. [Q13023-1 ]
    UniGenei Hs.509083.

    3D structure databases

    ProteinModelPortali Q13023.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114857. 10 interactions.
    IntActi Q13023. 11 interactions.
    STRINGi 9606.ENSP00000280979.

    PTM databases

    PhosphoSitei Q13023.

    Polymorphism databases

    DMDMi 116241243.

    Proteomic databases

    PaxDbi Q13023.
    PRIDEi Q13023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280979 ; ENSP00000280979 ; ENSG00000151320 . [Q13023-1 ]
    ENST00000557354 ; ENSP00000450531 ; ENSG00000151320 . [Q13023-2 ]
    GeneIDi 9472.
    KEGGi hsa:9472.
    UCSCi uc001wrq.3. human. [Q13023-1 ]

    Organism-specific databases

    CTDi 9472.
    GeneCardsi GC14P032798.
    HGNCi HGNC:376. AKAP6.
    HPAi CAB001983.
    MIMi 604691. gene.
    neXtProti NX_Q13023.
    PharmGKBi PA24670.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG119013.
    HOGENOMi HOG000001568.
    HOVERGENi HBG050480.
    InParanoidi Q13023.
    KOi K16523.
    OMAi NGSDSLQ.
    OrthoDBi EOG71G9T4.
    PhylomeDBi Q13023.
    TreeFami TF105405.

    Miscellaneous databases

    GeneWikii AKAP6.
    GenomeRNAii 9472.
    NextBioi 35463252.
    PROi Q13023.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13023.
    Bgeei Q13023.
    CleanExi HS_AKAP6.
    Genevestigatori Q13023.

    Family and domain databases

    InterProi IPR026696. AKAP6/CEP68.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    [Graphical view ]
    PANTHERi PTHR14514. PTHR14514. 1 hit.
    Pfami PF00435. Spectrin. 1 hit.
    [Graphical view ]
    SMARTi SM00150. SPEC. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes."
      Kapiloff M.S., Shillace R.V., Westphal A.M., Scott J.D.
      J. Cell Sci. 112:2725-2736(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-1492.
    2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    7. "Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum."
      McCartney S., Little B.M., Langeberg L.K., Scott J.D.
      J. Biol. Chem. 270:9327-9333(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1666-2319 (ISOFORM 1).
      Tissue: Hippocampus.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-910; ILE-1192; GLN-1702 AND THR-1839.

    Entry informationi

    Entry nameiAKAP6_HUMAN
    AccessioniPrimary (citable) accession number: Q13023
    Secondary accession number(s): A7E242, A7E2D4, O15028
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3