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Protein

MAL-like protein

Gene

MALL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cholesterol homeostasis Source: HGNC
  • membrane raft polarization Source: GO_Central
  • myelination Source: GO_Central
  • protein localization Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
MAL-like protein
Alternative name(s):
Protein BENE
Gene namesi
Name:MALL
Synonyms:BENE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6818. MALL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • clathrin-coated vesicle Source: HGNC
  • cytoplasmic vesicle Source: HGNC
  • Golgi membrane Source: HGNC
  • integral component of membrane Source: GO_Central
  • membrane raft Source: HGNC
  • plasma membrane Source: HGNC

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7851.
OpenTargetsiENSG00000144063.
PharmGKBiPA30567.

Polymorphism and mutation databases

BioMutaiMALL.
DMDMi21264403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568111 – 153MAL-like proteinAdd BLAST153

Proteomic databases

PaxDbiQ13021.
PeptideAtlasiQ13021.
PRIDEiQ13021.

PTM databases

iPTMnetiQ13021.
PhosphoSitePlusiQ13021.

Expressioni

Gene expression databases

BgeeiENSG00000144063.
CleanExiHS_MALL.
ExpressionAtlasiQ13021. baseline and differential.
GenevisibleiQ13021. HS.

Organism-specific databases

HPAiHPA051410.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113606. 9 interactors.
IntActiQ13021. 11 interactors.
MINTiMINT-1446880.
STRINGi9606.ENSP00000272462.

Structurei

3D structure databases

ProteinModelPortaliQ13021.
SMRiQ13021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 153MARVELPROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWII. Eukaryota.
ENOG410YQN9. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiQ13021.
OMAiYLFGFYK.
OrthoDBiEOG090A0E08.
PhylomeDBiQ13021.
TreeFamiTF316174.

Family and domain databases

InterProiView protein in InterPro
IPR013295. MAL.
IPR008253. Marvel.
PfamiView protein in Pfam
PF01284. MARVEL. 1 hit.
PRINTSiPR01884. MALPROTEIN.
PROSITEiView protein in PROSITE
PS51225. MARVEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPDPPATS YAPSDVPSGV ALFLTIPFAF FLPELIFGFL VWTMVAATHI
60 70 80 90 100
VYPLLQGWVM YVSLTSFLIS LMFLLSYLFG FYKRFESWRV LDSLYHGTTG
110 120 130 140 150
ILYMSAAVLQ VHATIVSEKL LDPRIYYINS AASFFAFIAT LLYILHAFSI

YYH
Length:153
Mass (Da):17,350
Last modified:May 27, 2002 - v2
Checksum:i83B30F1D950C5745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125647 mRNA. Translation: BAG54228.1.
CH878608 Genomic DNA. Translation: EAW50639.1.
BC003179 mRNA. Translation: AAH03179.1.
U17077 mRNA. Translation: AAA76738.1.
CCDSiCCDS2085.1.
PIRiI38891.
RefSeqiNP_005425.1. NM_005434.4.
UniGeneiHs.185055.

Genome annotation databases

EnsembliENST00000272462; ENSP00000272462; ENSG00000144063.
GeneIDi7851.
KEGGihsa:7851.
UCSCiuc002tfk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125647 mRNA. Translation: BAG54228.1.
CH878608 Genomic DNA. Translation: EAW50639.1.
BC003179 mRNA. Translation: AAH03179.1.
U17077 mRNA. Translation: AAA76738.1.
CCDSiCCDS2085.1.
PIRiI38891.
RefSeqiNP_005425.1. NM_005434.4.
UniGeneiHs.185055.

3D structure databases

ProteinModelPortaliQ13021.
SMRiQ13021.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113606. 9 interactors.
IntActiQ13021. 11 interactors.
MINTiMINT-1446880.
STRINGi9606.ENSP00000272462.

PTM databases

iPTMnetiQ13021.
PhosphoSitePlusiQ13021.

Polymorphism and mutation databases

BioMutaiMALL.
DMDMi21264403.

Proteomic databases

PaxDbiQ13021.
PeptideAtlasiQ13021.
PRIDEiQ13021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272462; ENSP00000272462; ENSG00000144063.
GeneIDi7851.
KEGGihsa:7851.
UCSCiuc002tfk.3. human.

Organism-specific databases

CTDi7851.
DisGeNETi7851.
GeneCardsiMALL.
HGNCiHGNC:6818. MALL.
HPAiHPA051410.
MIMi602022. gene.
neXtProtiNX_Q13021.
OpenTargetsiENSG00000144063.
PharmGKBiPA30567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWII. Eukaryota.
ENOG410YQN9. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiQ13021.
OMAiYLFGFYK.
OrthoDBiEOG090A0E08.
PhylomeDBiQ13021.
TreeFamiTF316174.

Miscellaneous databases

ChiTaRSiMALL. human.
GeneWikiiMALL.
GenomeRNAii7851.
PROiQ13021.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144063.
CleanExiHS_MALL.
ExpressionAtlasiQ13021. baseline and differential.
GenevisibleiQ13021. HS.

Family and domain databases

InterProiView protein in InterPro
IPR013295. MAL.
IPR008253. Marvel.
PfamiView protein in Pfam
PF01284. MARVEL. 1 hit.
PRINTSiPR01884. MALPROTEIN.
PROSITEiView protein in PROSITE
PS51225. MARVEL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMALL_HUMAN
AccessioniPrimary (citable) accession number: Q13021
Secondary accession number(s): B3KWR6, Q9BTU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: February 15, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.