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Protein

MAL-like protein

Gene

MALL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cholesterol homeostasis Source: HGNC
  • membrane raft polarization Source: GO_Central
  • myelination Source: GO_Central
  • protein localization Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
MAL-like protein
Alternative name(s):
Protein BENE
Gene namesi
Name:MALL
Synonyms:BENE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144063.3
HGNCiHGNC:6818 MALL
MIMi602022 gene
neXtProtiNX_Q13021

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7851
OpenTargetsiENSG00000144063
PharmGKBiPA30567

Polymorphism and mutation databases

BioMutaiMALL
DMDMi21264403

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568111 – 153MAL-like proteinAdd BLAST153

Proteomic databases

PaxDbiQ13021
PeptideAtlasiQ13021
PRIDEiQ13021
ProteomicsDBi59108

PTM databases

iPTMnetiQ13021
PhosphoSitePlusiQ13021

Expressioni

Gene expression databases

BgeeiENSG00000144063
CleanExiHS_MALL
ExpressionAtlasiQ13021 baseline and differential
GenevisibleiQ13021 HS

Organism-specific databases

HPAiHPA051410

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113606, 10 interactors
IntActiQ13021, 21 interactors
STRINGi9606.ENSP00000272462

Structurei

3D structure databases

ProteinModelPortaliQ13021
SMRiQ13021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 153MARVELPROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWII Eukaryota
ENOG410YQN9 LUCA
GeneTreeiENSGT00730000110762
HOGENOMiHOG000231752
HOVERGENiHBG000925
InParanoidiQ13021
OMAiHAFSIYY
OrthoDBiEOG091G0OS1
PhylomeDBiQ13021
TreeFamiTF316174

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequencei

Sequence statusi: Complete.

Q13021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPDPPATS YAPSDVPSGV ALFLTIPFAF FLPELIFGFL VWTMVAATHI
60 70 80 90 100
VYPLLQGWVM YVSLTSFLIS LMFLLSYLFG FYKRFESWRV LDSLYHGTTG
110 120 130 140 150
ILYMSAAVLQ VHATIVSEKL LDPRIYYINS AASFFAFIAT LLYILHAFSI

YYH
Length:153
Mass (Da):17,350
Last modified:May 27, 2002 - v2
Checksum:i83B30F1D950C5745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125647 mRNA Translation: BAG54228.1
CH878608 Genomic DNA Translation: EAW50639.1
BC003179 mRNA Translation: AAH03179.1
U17077 mRNA Translation: AAA76738.1
CCDSiCCDS2085.1
PIRiI38891
RefSeqiNP_005425.1, NM_005434.4
UniGeneiHs.185055

Genome annotation databases

EnsembliENST00000272462; ENSP00000272462; ENSG00000144063
GeneIDi7851
KEGGihsa:7851
UCSCiuc002tfk.3 human

Similar proteinsi

Entry informationi

Entry nameiMALL_HUMAN
AccessioniPrimary (citable) accession number: Q13021
Secondary accession number(s): B3KWR6, Q9BTU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: June 20, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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