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Protein

MAL-like protein

Gene

MALL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cholesterol homeostasis Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAL-like protein
Alternative name(s):
Protein BENE
Gene namesi
Name:MALL
Synonyms:BENE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6818. MALL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • clathrin-coated vesicle Source: HGNC
  • cytoplasmic, membrane-bounded vesicle Source: HGNC
  • Golgi membrane Source: HGNC
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: HGNC
  • plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30567.

Polymorphism and mutation databases

BioMutaiMALL.
DMDMi21264403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153MAL-like proteinPRO_0000156811Add
BLAST

Proteomic databases

PaxDbiQ13021.

Expressioni

Gene expression databases

BgeeiQ13021.
CleanExiHS_MALL.
ExpressionAtlasiQ13021. baseline and differential.
GenevisibleiQ13021. HS.

Organism-specific databases

HPAiHPA051410.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-750078,EBI-749265
GGT7Q9UJ143EBI-750078,EBI-1058791
LDLRAD1Q5T7003EBI-750078,EBI-10173166
MS4A12Q9NXJ03EBI-750078,EBI-10227644
MSR1P217573EBI-750078,EBI-1776976
SYNE4Q8N2053EBI-750078,EBI-7131783

Protein-protein interaction databases

BioGridi113606. 9 interactions.
IntActiQ13021. 7 interactions.
MINTiMINT-1446880.
STRINGi9606.ENSP00000272462.

Structurei

3D structure databases

ProteinModelPortaliQ13021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 153132MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWII. Eukaryota.
ENOG410YQN9. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiQ13021.
OMAiYLFGFYK.
OrthoDBiEOG7XM30H.
PhylomeDBiQ13021.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPDPPATS YAPSDVPSGV ALFLTIPFAF FLPELIFGFL VWTMVAATHI
60 70 80 90 100
VYPLLQGWVM YVSLTSFLIS LMFLLSYLFG FYKRFESWRV LDSLYHGTTG
110 120 130 140 150
ILYMSAAVLQ VHATIVSEKL LDPRIYYINS AASFFAFIAT LLYILHAFSI

YYH
Length:153
Mass (Da):17,350
Last modified:May 27, 2002 - v2
Checksum:i83B30F1D950C5745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125647 mRNA. Translation: BAG54228.1.
CH878608 Genomic DNA. Translation: EAW50639.1.
BC003179 mRNA. Translation: AAH03179.1.
U17077 mRNA. Translation: AAA76738.1.
CCDSiCCDS2085.1.
PIRiI38891.
RefSeqiNP_005425.1. NM_005434.4.
UniGeneiHs.185055.

Genome annotation databases

EnsembliENST00000272462; ENSP00000272462; ENSG00000144063.
GeneIDi7851.
KEGGihsa:7851.
UCSCiuc002tfk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125647 mRNA. Translation: BAG54228.1.
CH878608 Genomic DNA. Translation: EAW50639.1.
BC003179 mRNA. Translation: AAH03179.1.
U17077 mRNA. Translation: AAA76738.1.
CCDSiCCDS2085.1.
PIRiI38891.
RefSeqiNP_005425.1. NM_005434.4.
UniGeneiHs.185055.

3D structure databases

ProteinModelPortaliQ13021.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113606. 9 interactions.
IntActiQ13021. 7 interactions.
MINTiMINT-1446880.
STRINGi9606.ENSP00000272462.

Polymorphism and mutation databases

BioMutaiMALL.
DMDMi21264403.

Proteomic databases

PaxDbiQ13021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272462; ENSP00000272462; ENSG00000144063.
GeneIDi7851.
KEGGihsa:7851.
UCSCiuc002tfk.3. human.

Organism-specific databases

CTDi7851.
GeneCardsiMALL.
HGNCiHGNC:6818. MALL.
HPAiHPA051410.
MIMi602022. gene.
neXtProtiNX_Q13021.
PharmGKBiPA30567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWII. Eukaryota.
ENOG410YQN9. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiQ13021.
OMAiYLFGFYK.
OrthoDBiEOG7XM30H.
PhylomeDBiQ13021.
TreeFamiTF316174.

Miscellaneous databases

ChiTaRSiMALL. human.
GeneWikiiMALL.
GenomeRNAii7851.
NextBioi30282.
PROiQ13021.
SOURCEiSearch...

Gene expression databases

BgeeiQ13021.
CleanExiHS_MALL.
ExpressionAtlasiQ13021. baseline and differential.
GenevisibleiQ13021. HS.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "Searching for non-V kappa transcripts from the human immunoglobulin kappa locus."
    Lautner-Rieske A., Thiebe R., Zachau H.G.
    Gene 159:199-202(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-153.

Entry informationi

Entry nameiMALL_HUMAN
AccessioniPrimary (citable) accession number: Q13021
Secondary accession number(s): B3KWR6, Q9BTU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: March 16, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.