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Q13018

- PLA2R_HUMAN

UniProt

Q13018 - PLA2R_HUMAN

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Protein
Secretory phospholipase A2 receptor
Gene
PLA2R1, CLEC13C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.2 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. phospholipase binding Source: UniProtKB
  3. receptor activity Source: UniProtKB

GO - Biological processi

  1. cytokine production Source: UniProtKB
  2. negative regulation of arachidonic acid secretion Source: UniProtKB
  3. negative regulation of phospholipase A2 activity Source: UniProtKB
  4. oxidative stress-induced premature senescence Source: UniProtKB
  5. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  6. positive regulation of arachidonic acid secretion Source: UniProtKB
  7. reactive oxygen species metabolic process Source: UniProtKB
  8. receptor-mediated endocytosis Source: UniProtKB
  9. replicative senescence Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiS63.015.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory phospholipase A2 receptor
Short name:
PLA2-R
Short name:
PLA2R
Alternative name(s):
180 kDa secretory phospholipase A2 receptor
C-type lectin domain family 13 member C
M-type receptor
Cleaved into the following chain:
Soluble secretory phospholipase A2 receptor
Short name:
Soluble PLA2-R
Short name:
Soluble PLA2R
Gene namesi
Name:PLA2R1
Synonyms:CLEC13C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:9042. PLA2R1.

Subcellular locationi

Isoform 2 : Secreted Reviewed prediction

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 13971377Extracellular Reviewed prediction
Add
BLAST
Transmembranei1398 – 141821Helical; Reviewed prediction
Add
BLAST
Topological domaini1419 – 146345Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. extracellular region Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of membrane Source: UniProtKB-KW
  5. integral component of plasma membrane Source: UniProtKB
  6. plasma membrane Source: UniProtKB
  7. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarity
Add
BLAST
Chaini21 – 14631443Secretory phospholipase A2 receptor
PRO_5000144349Add
BLAST
Chaini21 – ?Soluble secretory phospholipase A2 receptor By similarityPRO_0000311250

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 64 By similarity
Disulfide bondi89 ↔ 106 By similarity
Glycosylationi93 – 931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi178 ↔ 204 By similarity
Disulfide bondi192 ↔ 219 By similarity
Disulfide bondi260 ↔ 354 By similarity
Disulfide bondi330 ↔ 346 By similarity
Disulfide bondi406 ↔ 501 By similarity
Glycosylationi454 – 4541N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi478 ↔ 493 By similarity
Disulfide bondi617 ↔ 634 By similarity
Disulfide bondi699 ↔ 796 By similarity
Disulfide bondi774 ↔ 788 By similarity
Disulfide bondi840 ↔ 937 By similarity
Disulfide bondi914 ↔ 929 By similarity
Disulfide bondi1067 ↔ 1087 By similarity
Disulfide bondi1209 ↔ 1223 By similarity
Disulfide bondi1280 ↔ 1377 By similarity
Disulfide bondi1354 ↔ 1369 By similarity

Post-translational modificationi

The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13018.
PRIDEiQ13018.

Expressioni

Tissue specificityi

Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.4 Publications

Gene expression databases

BgeeiQ13018.
CleanExiHS_PLA2R1.
GenevestigatoriQ13018.

Organism-specific databases

HPAiHPA012657.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000283243.

Structurei

3D structure databases

ProteinModelPortaliQ13018.
SMRiQ13018. Positions 132-223, 229-355, 377-502, 664-805, 816-939, 957-1101, 1119-1232, 1254-1382.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 161124Ricin B-type lectin
Add
BLAST
Domaini173 – 22149Fibronectin type-II
Add
BLAST
Domaini238 – 355118C-type lectin 1
Add
BLAST
Domaini385 – 502118C-type lectin 2
Add
BLAST
Domaini522 – 643122C-type lectin 3
Add
BLAST
Domaini673 – 797125C-type lectin 4
Add
BLAST
Domaini819 – 938120C-type lectin 5
Add
BLAST
Domaini965 – 1096132C-type lectin 6
Add
BLAST
Domaini1121 – 1232112C-type lectin 7
Add
BLAST
Domaini1257 – 1378122C-type lectin 8
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1436 – 14427Endocytosis signal

Domaini

C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
The endocytosis signal probably mediates endocytosis via clathrin-coated pits By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288621.
HOVERGENiHBG108261.
InParanoidiQ13018.
KOiK06560.
OMAiWCATTSR.
OrthoDBiEOG7FFMQR.
PhylomeDBiQ13018.
TreeFamiTF316663.

Family and domain databases

Gene3Di2.10.10.10. 1 hit.
3.10.100.10. 8 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000562. FN_type2_col-bd.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF00059. Lectin_C. 8 hits.
[Graphical view]
SMARTiSM00034. CLECT. 8 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 8 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 3 hits.
PS50041. C_TYPE_LECTIN_2. 8 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13018-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLSPSLLLL LLLGAPRGCA EGVAAALTPE RLLEWQDKGI FVIQSESLKK     50
CIQAGKSVLT LENCKQANKH MLWKWVSNHG LFNIGGSGCL GLNFSAPEQP 100
LSLYECDSTL VSLRWRCNRK MITGPLQYSV QVAHDNTVVA SRKYIHKWIS 150
YGSGGGDICE YLHKDLHTIK GNTHGMPCMF PFQYNHQWHH ECTREGREDD 200
LLWCATTSRY ERDEKWGFCP DPTSAEVGCD TIWEKDLNSH ICYQFNLLSS 250
LSWSEAHSSC QMQGGTLLSI TDETEENFIR EHMSSKTVEV WMGLNQLDEH 300
AGWQWSDGTP LNYLNWSPEV NFEPFVEDHC GTFSSFMPSA WRSRDCESTL 350
PYICKKYLNH IDHEIVEKDA WKYYATHCEP GWNPYNRNCY KLQKEEKTWH 400
EALRSCQADN SALIDITSLA EVEFLVTLLG DENASETWIG LSSNKIPVSF 450
EWSNDSSVIF TNWHTLEPHI FPNRSQLCVS AEQSEGHWKV KNCEERLFYI 500
CKKAGHVLSD AESGCQEGWE RHGGFCYKID TVLRSFDQAS SGYYCPPALV 550
TITNRFEQAF ITSLISSVVK MKDSYFWIAL QDQNDTGEYT WKPVGQKPEP 600
VQYTHWNTHQ PRYSGGCVAM RGRHPLGRWE VKHCRHFKAM SLCKQPVENQ 650
EKAEYEERWP FHPCYLDWES EPGLASCFKV FHSEKVLMKR TWREAEAFCE 700
EFGAHLASFA HIEEENFVNE LLHSKFNWTE ERQFWIGFNK RNPLNAGSWE 750
WSDRTPVVSS FLDNTYFGED ARNCAVYKAN KTLLPLHCGS KREWICKIPR 800
DVKPKIPFWY QYDVPWLFYQ DAEYLFHTFA SEWLNFEFVC SWLHSDLLTI 850
HSAHEQEFIH SKIKALSKYG ASWWIGLQEE RANDEFRWRD GTPVIYQNWD 900
TGRERTVNNQ SQRCGFISSI TGLWGSEECS VSMPSICKRK KVWLIEKKKD 950
TPKQHGTCPK GWLYFNYKCL LLNIPKDPSS WKNWTHAQHF CAEEGGTLVA 1000
IESEVEQAFI TMNLFGQTTS VWIGLQNDDY ETWLNGKPVV YSNWSPFDII 1050
NIPSHNTTEV QKHIPLCALL SSNPNFHFTG KWYFEDCGKE GYGFVCEKMQ 1100
DTSGHGVNTS DMYPMPNTLE YGNRTYKIIN ANMTWYAAIK TCLMHKAQLV 1150
SITDQYHQSF LTVVLNRLGY AHWIGLFTTD NGLNFDWSDG TKSSFTFWKD 1200
EESSLLGDCV FADSNGRWHS TACESFLQGA ICHVPPETRQ SEHPELCSET 1250
SIPWIKFKSN CYSFSTVLDS MSFEAAHEFC KKEGSNLLTI KDEAENAFLL 1300
EELFAFGSSV QMVWLNAQFD GNNETIKWFD GTPTDQSNWG IRKPDTDYFK 1350
PHHCVALRIP EGLWQLSPCQ EKKGFICKME ADIHTAEALP EKGPSHSIIP 1400
LAVVLTLIVI VAICTLSFCI YKHNGGFFRR LAGFRNPYYP ATNFSTVYLE 1450
ENILISDLEK SDQ 1463
Length:1,463
Mass (Da):168,600
Last modified:November 13, 2007 - v2
Checksum:i4E65EA5AC5D597E2
GO
Isoform 2 (identifier: Q13018-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1323-1324: NE → SK
     1325-1463: Missing.

Show »
Length:1,324
Mass (Da):152,805
Checksum:iE00D5FDFF05DC9FC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421R → Q.
Corresponds to variant rs12327936 [ dbSNP | Ensembl ].
VAR_037203
Natural varianti177 – 1771P → S.
Corresponds to variant rs13394676 [ dbSNP | Ensembl ].
VAR_037204
Natural varianti279 – 2791I → V.
Corresponds to variant rs965290 [ dbSNP | Ensembl ].
VAR_037205
Natural varianti292 – 2921M → V.1 Publication
Corresponds to variant rs3749117 [ dbSNP | Ensembl ].
VAR_037206
Natural varianti300 – 3001H → D.1 Publication
Corresponds to variant rs35771982 [ dbSNP | Ensembl ].
VAR_037207
Natural varianti370 – 3701A → E.
Corresponds to variant rs34916310 [ dbSNP | Ensembl ].
VAR_061354
Natural varianti404 – 4041R → H.
Corresponds to variant rs33985939 [ dbSNP | Ensembl ].
VAR_037208
Natural varianti1106 – 11061G → S.
Corresponds to variant rs3828323 [ dbSNP | Ensembl ].
VAR_037209

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1323 – 13242NE → SK in isoform 2.
VSP_029493
Alternative sequencei1325 – 1463139Missing in isoform 2.
VSP_029494Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 173APR → GAA in AAA70110. 1 Publication
Sequence conflicti15 – 173APR → GAA in AAC50163. 1 Publication
Sequence conflicti62 – 643ENC → GRTGS in AAA70110. 1 Publication
Sequence conflicti62 – 643ENC → GRTGS in AAC50163. 1 Publication
Sequence conflicti521 – 5233RHG → ETC in AAA70110. 1 Publication
Sequence conflicti521 – 5233RHG → ETC in AAC50163. 1 Publication
Sequence conflicti724 – 7241S → P in AAA70110. 1 Publication
Sequence conflicti724 – 7241S → P in AAC50163. 1 Publication
Sequence conflicti779 – 7791A → P in AAA70110. 1 Publication
Sequence conflicti779 – 7791A → P in AAC50163. 1 Publication
Sequence conflicti1224 – 12241E → D in AAA70110. 1 Publication
Sequence conflicti1224 – 12241E → D in AAC50163. 1 Publication
Sequence conflicti1263 – 12631S → K in AAA70110. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17033 mRNA. Translation: AAA70110.1.
U17034 mRNA. Translation: AAC50163.1.
AC080166 Genomic DNA. Translation: AAY24052.1.
AC093873 Genomic DNA. Translation: AAY24190.1.
CH471058 Genomic DNA. Translation: EAX11392.1.
CH471058 Genomic DNA. Translation: EAX11393.1.
BC140823 mRNA. Translation: AAI40824.1.
D30780 mRNA. Translation: BAA06444.1.
CCDSiCCDS33309.1. [Q13018-1]
CCDS42767.1. [Q13018-2]
PIRiA56395.
B56395.
RefSeqiNP_001007268.1. NM_001007267.2. [Q13018-2]
NP_001182570.1. NM_001195641.1.
NP_031392.3. NM_007366.4. [Q13018-1]
XP_005246449.1. XM_005246392.1. [Q13018-1]
UniGeneiHs.410477.

Genome annotation databases

EnsembliENST00000283243; ENSP00000283243; ENSG00000153246. [Q13018-1]
ENST00000392771; ENSP00000376524; ENSG00000153246. [Q13018-2]
GeneIDi22925.
KEGGihsa:22925.
UCSCiuc002ube.2. human. [Q13018-1]
uc002ubf.3. human. [Q13018-2]

Polymorphism databases

DMDMi160419241.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Phospholipase A2 receptor

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17033 mRNA. Translation: AAA70110.1 .
U17034 mRNA. Translation: AAC50163.1 .
AC080166 Genomic DNA. Translation: AAY24052.1 .
AC093873 Genomic DNA. Translation: AAY24190.1 .
CH471058 Genomic DNA. Translation: EAX11392.1 .
CH471058 Genomic DNA. Translation: EAX11393.1 .
BC140823 mRNA. Translation: AAI40824.1 .
D30780 mRNA. Translation: BAA06444.1 .
CCDSi CCDS33309.1. [Q13018-1 ]
CCDS42767.1. [Q13018-2 ]
PIRi A56395.
B56395.
RefSeqi NP_001007268.1. NM_001007267.2. [Q13018-2 ]
NP_001182570.1. NM_001195641.1.
NP_031392.3. NM_007366.4. [Q13018-1 ]
XP_005246449.1. XM_005246392.1. [Q13018-1 ]
UniGenei Hs.410477.

3D structure databases

ProteinModelPortali Q13018.
SMRi Q13018. Positions 132-223, 229-355, 377-502, 664-805, 816-939, 957-1101, 1119-1232, 1254-1382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000283243.

Protein family/group databases

MEROPSi S63.015.

Polymorphism databases

DMDMi 160419241.

Proteomic databases

PaxDbi Q13018.
PRIDEi Q13018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283243 ; ENSP00000283243 ; ENSG00000153246 . [Q13018-1 ]
ENST00000392771 ; ENSP00000376524 ; ENSG00000153246 . [Q13018-2 ]
GeneIDi 22925.
KEGGi hsa:22925.
UCSCi uc002ube.2. human. [Q13018-1 ]
uc002ubf.3. human. [Q13018-2 ]

Organism-specific databases

CTDi 22925.
GeneCardsi GC02M160788.
H-InvDB HIX0024010.
HGNCi HGNC:9042. PLA2R1.
HPAi HPA012657.
MIMi 604939. gene.
neXtProti NX_Q13018.
PharmGKBi PA33369.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288621.
HOVERGENi HBG108261.
InParanoidi Q13018.
KOi K06560.
OMAi WCATTSR.
OrthoDBi EOG7FFMQR.
PhylomeDBi Q13018.
TreeFami TF316663.

Miscellaneous databases

ChiTaRSi PLA2R1. human.
GenomeRNAii 22925.
NextBioi 43633.
PROi Q13018.
SOURCEi Search...

Gene expression databases

Bgeei Q13018.
CleanExi HS_PLA2R1.
Genevestigatori Q13018.

Family and domain databases

Gene3Di 2.10.10.10. 1 hit.
3.10.100.10. 8 hits.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000562. FN_type2_col-bd.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00040. fn2. 1 hit.
PF00059. Lectin_C. 8 hits.
[Graphical view ]
SMARTi SM00034. CLECT. 8 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 8 hits.
PROSITEi PS00615. C_TYPE_LECTIN_1. 3 hits.
PS50041. C_TYPE_LECTIN_2. 8 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization."
    Ancian P., Lambeau G., Mattei M.-G., Lazdunski M.
    J. Biol. Chem. 270:8963-8970(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, VARIANTS VAL-292 AND ASP-300.
    Tissue: Kidney.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals."
    Higashino K., Ishizaki J., Kishino J., Ohara O., Arita H.
    Eur. J. Biochem. 225:375-382(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 532-942, TISSUE SPECIFICITY.
    Tissue: Placenta.
  6. "Distribution of the phospholipase A2 receptor messenger RNA in human gestational tissues."
    Moses E.K., Freed K.A., Brennecke S.P., Rice G.E.
    Placenta 19:35-40(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor."
    Granata F., Petraroli A., Boilard E., Bezzine S., Bollinger J., Del Vecchio L., Gelb M.H., Lambeau G., Marone G., Triggiani M.
    J. Immunol. 174:464-474(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLA2R_HUMAN
AccessioniPrimary (citable) accession number: Q13018
Secondary accession number(s): B2RTU9
, D3DPB1, Q13019, Q15095, Q53R45, Q53RR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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