Q13015 (AF1Q_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein AF1q

Gene names

Name:	MLLT11
Synonyms:	AF1Q

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Highly expressed in thymus and all leukemic cell lines. Ref.1
Involvement in disease	A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with MLL.
Sequence similarities	Belongs to the MLLT11 family.

Ontologies

Keywords
Coding sequence diversity	Chromosomal rearrangement
Disease	Proto-oncogene
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	extrinsic apoptotic signaling pathway Inferred from direct assay PubMed 18852119. Source: UniProtKB intrinsic apoptotic signaling pathway Inferred from direct assay PubMed 18852119. Source: UniProtKB positive regulation of apoptotic process Inferred from mutant phenotype PubMed 18852119. Source: UniProtKB positive regulation of mitochondrial depolarization Inferred from direct assay PubMed 18852119. Source: UniProtKB positive regulation of release of cytochrome c from mitochondria Inferred from direct assay PubMed 18852119. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 18852119. Source: UniProtKB
Cellular_component	intracellular Inferred from direct assay PubMed 18852119. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 90	90	Protein AF1q		PRO_0000064471

Sequences

	Sequence		Length	Mass (Da)
	Q13015 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B37C6F7303C9EBF8	FASTA	90	10,061
	10 20 30 40 50 60 MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKV KDSSVGKMIG QATAADQEKN 70 80 90 PEGDGLLEYS TFNFWRAPIA SIHSFELDLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells." Tse W., Zhu W., Chen H.S., Cohen A. Blood 85:650-656(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL REARRANGEMENT, TISSUE SPECIFICITY.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow, Brain and Lung.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	U16954 mRNA. Translation: AAA70088.1. BT006799 mRNA. Translation: AAP35445.1. CR456879 mRNA. Translation: CAG33160.1. AL590133 Genomic DNA. Translation: CAI13350.1. BC006471 mRNA. No translation available. BC008445 mRNA. Translation: AAH08445.1. BC009624 mRNA. Translation: AAH09624.1. BC019253 mRNA. Translation: AAH19253.1. BC021703 mRNA. Translation: AAH21703.1. BC022448 mRNA. Translation: AAH22448.1.
IPI	IPI00011421.
PIR	I38889.
RefSeq	NP_006809.1. NM_006818.3.
UniGene	Hs.75823.
3D structure databases
ProteinModelPortal	Q13015.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13015. 1 interaction.
STRING	9606.ENSP00000357917.
PTM databases
PhosphoSite	Q13015.
Proteomic databases
PaxDb	Q13015.
PRIDE	Q13015.
Protocols and materials databases
DNASU	10962.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368921; ENSP00000357917; ENSG00000213190.
GeneID	10962.
KEGG	hsa:10962.
UCSC	uc001ewq.3. human.
Organism-specific databases
CTD	10962.
GeneCards	GC01P151030.
HGNC	HGNC:16997. MLLT11.
HPA	HPA000540.
MIM	604684. gene.
neXtProt	NX_Q13015.
PharmGKB	PA142671347.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40082.
HOGENOM	HOG000033833.
InParanoid	Q13015.
OMA	KMTGQAT.
OrthoDB	EOG4ZKJNX.
Gene expression databases
ArrayExpress	Q13015.
Bgee	Q13015.
CleanEx	HS_MLLT11.
Genevestigator	Q13015.
GermOnline	ENSG00000143443. Homo sapiens.
Family and domain databases
InterPro	IPR026778. MLLT11_fam. [Graphical view]
PANTHER	PTHR15404. PTHR15404. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MLLT11. human.
GenomeRNAi	10962.
NextBio	41658.
SOURCE	Search...

Entry information

Entry name

AF1Q_HUMAN

Accession

Primary (citable) accession number: Q13015

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.