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Protein

Protein AF1q

Gene

MLLT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).2 Publications

GO - Biological processi

  • extrinsic apoptotic signaling pathway Source: UniProtKB
  • intrinsic apoptotic signaling pathway Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of mitochondrial depolarization Source: UniProtKB
  • positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143443-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AF1q
Gene namesi
Name:MLLT11
Synonyms:AF1Q
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16997. MLLT11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • intracellular Source: UniProtKB
  • microtubule organizing center Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24 – 32LSELEGLGL → ASEAEGAGA: Constitutive nuclear sequestration. 1 Publication9

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi10962.
OpenTargetsiENSG00000213190.
PharmGKBiPA142671347.

Polymorphism and mutation databases

BioMutaiMLLT11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000644711 – 90Protein AF1qAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated, leading to degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13015.
PaxDbiQ13015.
PeptideAtlasiQ13015.
PRIDEiQ13015.
TopDownProteomicsiQ13015.

PTM databases

iPTMnetiQ13015.
PhosphoSitePlusiQ13015.

Expressioni

Tissue specificityi

Expressed in myoepithelial cells of normal breast tissue (at protein level) (PubMed:26079538). Highly expressed in thymus (PubMed:7833468). Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen (PubMed:7833468).2 Publications

Gene expression databases

BgeeiENSG00000213190.
CleanExiHS_MLLT11.
ExpressionAtlasiQ13015. baseline and differential.
GenevisibleiQ13015. HS.

Organism-specific databases

HPAiHPA000540.

Interactioni

Subunit structurei

Interacts with HSPA8 and LAMP2 isoform A; the interaction may target MLLT11 for degradation via chaperone-mediated autophagy (PubMed:24880125). Interacts with TCF7 (PubMed:26079538).2 Publications

Protein-protein interaction databases

BioGridi116161. 4 interactors.
IntActiQ13015. 3 interactors.
MINTiMINT-4718428.
STRINGi9606.ENSP00000357917.

Structurei

3D structure databases

ProteinModelPortaliQ13015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi24 – 32Nuclear export signal1 Publication9

Sequence similaritiesi

Belongs to the MLLT11 family.Curated

Phylogenomic databases

eggNOGiENOG410IZF7. Eukaryota.
ENOG4112CHF. LUCA.
GeneTreeiENSGT00390000009895.
HOGENOMiHOG000033833.
InParanoidiQ13015.
OMAiKMTGQAT.
OrthoDBiEOG091G10XZ.
PhylomeDBiQ13015.
TreeFamiTF336906.

Family and domain databases

InterProiIPR026778. MLLT11_fam.
IPR033461. WRNPLPNID.
[Graphical view]
PANTHERiPTHR15404. PTHR15404. 1 hit.
PfamiPF15017. WRNPLPNID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKV KDSSVGKMIG
60 70 80 90
QATAADQEKN PEGDGLLEYS TFNFWRAPIA SIHSFELDLL
Length:90
Mass (Da):10,061
Last modified:November 1, 1996 - v1
Checksum:iB37C6F7303C9EBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16954 mRNA. Translation: AAA70088.1.
BT006799 mRNA. Translation: AAP35445.1.
CR456879 mRNA. Translation: CAG33160.1.
AL590133 Genomic DNA. Translation: CAI13350.1.
BC006471 mRNA. No translation available.
BC008445 mRNA. Translation: AAH08445.1.
BC009624 mRNA. Translation: AAH09624.1.
BC019253 mRNA. Translation: AAH19253.1.
BC021703 mRNA. Translation: AAH21703.1.
BC022448 mRNA. Translation: AAH22448.1.
CCDSiCCDS982.1.
PIRiI38889.
RefSeqiNP_006809.1. NM_006818.3.
UniGeneiHs.75823.

Genome annotation databases

EnsembliENST00000368921; ENSP00000357917; ENSG00000213190.
GeneIDi10962.
KEGGihsa:10962.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16954 mRNA. Translation: AAA70088.1.
BT006799 mRNA. Translation: AAP35445.1.
CR456879 mRNA. Translation: CAG33160.1.
AL590133 Genomic DNA. Translation: CAI13350.1.
BC006471 mRNA. No translation available.
BC008445 mRNA. Translation: AAH08445.1.
BC009624 mRNA. Translation: AAH09624.1.
BC019253 mRNA. Translation: AAH19253.1.
BC021703 mRNA. Translation: AAH21703.1.
BC022448 mRNA. Translation: AAH22448.1.
CCDSiCCDS982.1.
PIRiI38889.
RefSeqiNP_006809.1. NM_006818.3.
UniGeneiHs.75823.

3D structure databases

ProteinModelPortaliQ13015.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116161. 4 interactors.
IntActiQ13015. 3 interactors.
MINTiMINT-4718428.
STRINGi9606.ENSP00000357917.

PTM databases

iPTMnetiQ13015.
PhosphoSitePlusiQ13015.

Polymorphism and mutation databases

BioMutaiMLLT11.

Proteomic databases

EPDiQ13015.
PaxDbiQ13015.
PeptideAtlasiQ13015.
PRIDEiQ13015.
TopDownProteomicsiQ13015.

Protocols and materials databases

DNASUi10962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368921; ENSP00000357917; ENSG00000213190.
GeneIDi10962.
KEGGihsa:10962.

Organism-specific databases

CTDi10962.
DisGeNETi10962.
GeneCardsiMLLT11.
HGNCiHGNC:16997. MLLT11.
HPAiHPA000540.
MIMi604684. gene.
neXtProtiNX_Q13015.
OpenTargetsiENSG00000213190.
PharmGKBiPA142671347.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZF7. Eukaryota.
ENOG4112CHF. LUCA.
GeneTreeiENSGT00390000009895.
HOGENOMiHOG000033833.
InParanoidiQ13015.
OMAiKMTGQAT.
OrthoDBiEOG091G10XZ.
PhylomeDBiQ13015.
TreeFamiTF336906.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143443-MONOMER.

Miscellaneous databases

ChiTaRSiMLLT11. human.
GenomeRNAii10962.
PROiQ13015.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213190.
CleanExiHS_MLLT11.
ExpressionAtlasiQ13015. baseline and differential.
GenevisibleiQ13015. HS.

Family and domain databases

InterProiIPR026778. MLLT11_fam.
IPR033461. WRNPLPNID.
[Graphical view]
PANTHERiPTHR15404. PTHR15404. 1 hit.
PfamiPF15017. WRNPLPNID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAF1Q_HUMAN
AccessioniPrimary (citable) accession number: Q13015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.