Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q13015

- AF1Q_HUMAN

UniProt

Q13015 - AF1Q_HUMAN

Protein

Protein AF1q

Gene

MLLT11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. extrinsic apoptotic signaling pathway Source: UniProtKB
    2. intrinsic apoptotic signaling pathway Source: UniProtKB
    3. positive regulation of apoptotic process Source: UniProtKB
    4. positive regulation of mitochondrial depolarization Source: UniProtKB
    5. positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
    6. positive regulation of transcription, DNA-templated Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein AF1q
    Gene namesi
    Name:MLLT11
    Synonyms:AF1Q
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16997. MLLT11.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA142671347.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9090Protein AF1qPRO_0000064471Add
    BLAST

    Proteomic databases

    MaxQBiQ13015.
    PaxDbiQ13015.
    PRIDEiQ13015.

    PTM databases

    PhosphoSiteiQ13015.

    Expressioni

    Tissue specificityi

    Highly expressed in thymus and all leukemic cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ13015.
    BgeeiQ13015.
    CleanExiHS_MLLT11.
    GenevestigatoriQ13015.

    Organism-specific databases

    HPAiHPA000540.

    Interactioni

    Protein-protein interaction databases

    BioGridi116161. 3 interactions.
    IntActiQ13015. 2 interactions.
    MINTiMINT-4718428.
    STRINGi9606.ENSP00000357917.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13015.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MLLT11 family.Curated

    Phylogenomic databases

    eggNOGiNOG40082.
    HOGENOMiHOG000033833.
    InParanoidiQ13015.
    OMAiKMTGQAT.
    OrthoDBiEOG7TBC4V.
    PhylomeDBiQ13015.
    TreeFamiTF336906.

    Family and domain databases

    InterProiIPR026778. MLLT11_fam.
    [Graphical view]
    PANTHERiPTHR15404. PTHR15404. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q13015-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKV KDSSVGKMIG   50
    QATAADQEKN PEGDGLLEYS TFNFWRAPIA SIHSFELDLL 90
    Length:90
    Mass (Da):10,061
    Last modified:November 1, 1996 - v1
    Checksum:iB37C6F7303C9EBF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16954 mRNA. Translation: AAA70088.1.
    BT006799 mRNA. Translation: AAP35445.1.
    CR456879 mRNA. Translation: CAG33160.1.
    AL590133 Genomic DNA. Translation: CAI13350.1.
    BC006471 mRNA. No translation available.
    BC008445 mRNA. Translation: AAH08445.1.
    BC009624 mRNA. Translation: AAH09624.1.
    BC019253 mRNA. Translation: AAH19253.1.
    BC021703 mRNA. Translation: AAH21703.1.
    BC022448 mRNA. Translation: AAH22448.1.
    CCDSiCCDS982.1.
    PIRiI38889.
    RefSeqiNP_006809.1. NM_006818.3.
    UniGeneiHs.75823.

    Genome annotation databases

    EnsembliENST00000368921; ENSP00000357917; ENSG00000213190.
    GeneIDi10962.
    KEGGihsa:10962.
    UCSCiuc001ewq.3. human.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16954 mRNA. Translation: AAA70088.1 .
    BT006799 mRNA. Translation: AAP35445.1 .
    CR456879 mRNA. Translation: CAG33160.1 .
    AL590133 Genomic DNA. Translation: CAI13350.1 .
    BC006471 mRNA. No translation available.
    BC008445 mRNA. Translation: AAH08445.1 .
    BC009624 mRNA. Translation: AAH09624.1 .
    BC019253 mRNA. Translation: AAH19253.1 .
    BC021703 mRNA. Translation: AAH21703.1 .
    BC022448 mRNA. Translation: AAH22448.1 .
    CCDSi CCDS982.1.
    PIRi I38889.
    RefSeqi NP_006809.1. NM_006818.3.
    UniGenei Hs.75823.

    3D structure databases

    ProteinModelPortali Q13015.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116161. 3 interactions.
    IntActi Q13015. 2 interactions.
    MINTi MINT-4718428.
    STRINGi 9606.ENSP00000357917.

    PTM databases

    PhosphoSitei Q13015.

    Proteomic databases

    MaxQBi Q13015.
    PaxDbi Q13015.
    PRIDEi Q13015.

    Protocols and materials databases

    DNASUi 10962.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368921 ; ENSP00000357917 ; ENSG00000213190 .
    GeneIDi 10962.
    KEGGi hsa:10962.
    UCSCi uc001ewq.3. human.

    Organism-specific databases

    CTDi 10962.
    GeneCardsi GC01P151030.
    HGNCi HGNC:16997. MLLT11.
    HPAi HPA000540.
    MIMi 604684. gene.
    neXtProti NX_Q13015.
    PharmGKBi PA142671347.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40082.
    HOGENOMi HOG000033833.
    InParanoidi Q13015.
    OMAi KMTGQAT.
    OrthoDBi EOG7TBC4V.
    PhylomeDBi Q13015.
    TreeFami TF336906.

    Miscellaneous databases

    ChiTaRSi MLLT11. human.
    GenomeRNAii 10962.
    NextBioi 41658.
    PROi Q13015.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13015.
    Bgeei Q13015.
    CleanExi HS_MLLT11.
    Genevestigatori Q13015.

    Family and domain databases

    InterProi IPR026778. MLLT11_fam.
    [Graphical view ]
    PANTHERi PTHR15404. PTHR15404. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells."
      Tse W., Zhu W., Chen H.S., Cohen A.
      Blood 85:650-656(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL REARRANGEMENT, TISSUE SPECIFICITY.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow, Brain and Lung.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAF1Q_HUMAN
    AccessioniPrimary (citable) accession number: Q13015
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3