Reviewed, UniProtKB/Swiss-Prot Q13014 (BAK2_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative Bcl-2 homologous antagonist/killer 2
Alternative name(s):
    Apoptosis regulator BAK-2

Gene names

Name:	BCL2L7P1
Synonyms:	BAK2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain.

General annotation (Comments)

Function	In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor Bcl-2 or its adenovirus homolog E1B 19k protein.
Subunit structure	Forms heterodimers with Bcl-2, E1B 19k protein, and Bcl-X(L).
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Domain	Intact BH3 domain is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family.
Sequence similarities	Belongs to the Bcl-2 family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Domain	Transmembrane
PTM	Acetylation
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW induction of apoptosis Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed

Chain

2 – 211

210

Putative Bcl-2 homologous antagonist/killer 2

PRO_0000159086

Regions

Transmembrane

188 – 205

18

Potential

Motif

74 – 88

15

BH3

Motif

117 – 136

20

BH1

Motif

169 – 184

16

BH2

Amino acid modifications

Modified residue

2

1

N-acetylalanine

Secondary structure

1

.

.

.

.

211

Helix Strand Turn

Details...

Helix

70 – 85

16

Turn

86 – 88

3

Sequences

	Sequence		Length	Mass (Da)
	Q13014-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 703875EC4DCCC1D3	FASTA	211	23,411
	10 20 30 40 50 60 MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YHHQQEQEAE GAAAPADPEM 70 80 90 100 110 120 VTLPLQPSST MGQVGRQLAI IGDDINRRYD SEFQTMLQHL QPTAENAYEY FTKIASSLFE 130 140 150 160 170 180 SGINWGRVVA LLGFSYRLAL HIYQRGLTGF LGQVTRFVVD FMLHHCIARW IAQRGGWVAA 190 200 210 LNLGNGPILN VLVVLGVVLL GQFVVRRFFK S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." Kiefer M.C., Brauer M.J., Powers V.C., Wu J.J., Umansky S.R., Tomei L.D., Barr P.J. Nature 374:736-739(1995) [PubMed: 7715731] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

U16812 Genomic DNA. Translation: AAA74467.1.
BX640505 Genomic DNA. No translation available.

IPI

IPI00815814.

PIR

S58875.

RefSeq

XP_002348091.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2JBY	X-ray	2.41	B	67-92	[»]

SMR

Q13014. Positions 21-183.

ModBase

Search...

Genome annotation databases

Ensembl

ENST00000374467; ENSP00000363591; ENSG00000030110; Homo sapiens. [Genome view]

GeneID

100289713.

KEGG

hsa:100289713.

Organism-specific databases

GeneCards

GC20M030741.

HGNC

HGNC:996. BCL2L7P1.

PharmGKB

PA25308.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q13014.

HOVERGEN

Q13014.

Gene expression databases

ArrayExpress

Q13014.

Bgee

Q13014.

Genevestigator

Q13014.

GermOnline

ENSG00000198179. Homo sapiens.

Family and domain databases

InterPro

IPR002475. BCL2_apoptsis.
IPR000712. Bcl2_BH.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
[Graphical view]

Pfam

PF00452. Bcl-2. 1 hit.
[Graphical view]

PRINTS

PR01862. BCL2FAMILY.

SMART

SM00337. BCL. 1 hit.
[Graphical view]

PROSITE

PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

BAK2_HUMAN

Accession

Primary (citable) accession number: Q13014

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.