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Q13007

- IL24_HUMAN

UniProt

Q13007 - IL24_HUMAN

Protein

Interleukin-24

Gene

IL24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cellular response to interleukin-4 Source: Ensembl
    3. cellular response to lipopolysaccharide Source: Ensembl
    4. negative regulation of apoptotic process Source: Ensembl
    5. negative regulation of cell migration Source: Ensembl
    6. negative regulation of cell proliferation Source: Ensembl
    7. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    8. positive regulation of apoptotic process Source: Ensembl
    9. positive regulation of cell proliferation Source: Ensembl
    10. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    11. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    12. serine phosphorylation of STAT3 protein Source: Ensembl
    13. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    SignaLinkiQ13007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-24
    Short name:
    IL-24
    Alternative name(s):
    Melanoma differentiation-associated gene 7 protein
    Short name:
    MDA-7
    Suppression of tumorigenicity 16 protein
    Gene namesi
    Name:IL24
    Synonyms:MDA7, ST16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11346. IL24.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29825.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 51511 PublicationAdd
    BLAST
    Chaini52 – 206155Interleukin-24PRO_0000015386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Cross-linki122 – 122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitination at Lys-122 promotes proteasomal degradation.1 Publication

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ13007.
    PRIDEiQ13007.

    PTM databases

    PhosphoSiteiQ13007.

    Expressioni

    Tissue specificityi

    Up-regulated in melanoma cells induced to terminally differentiate.

    Gene expression databases

    ArrayExpressiQ13007.
    BgeeiQ13007.
    CleanExiHS_IL24.
    GenevestigatoriQ13007.

    Organism-specific databases

    HPAiCAB025972.
    HPA008252.

    Interactioni

    Protein-protein interaction databases

    BioGridi116199. 5 interactions.
    IntActiQ13007. 3 interactions.
    STRINGi9606.ENSP00000294984.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13007.
    SMRiQ13007. Positions 67-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45557.
    HOGENOMiHOG000113033.
    HOVERGENiHBG098494.
    KOiK05444.
    OMAiVDILLTW.
    OrthoDBiEOG7060SK.
    PhylomeDBiQ13007.
    TreeFamiTF333253.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    IPR020444. IL-24.
    [Graphical view]
    PANTHERiPTHR11585. PTHR11585. 1 hit.
    PRINTSiPR01937. INTRLEUKIN24.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13007-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ    50
    GQEFHFGPCQ VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV 100
    SDAESCYLVH TLLEFYLKTV FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ 150
    LQPSQENEMF SIRDSAHRRF LLFRRAFKQL DVEAALTKAL GEVDILLTWM 200
    QKFYKL 206
    Length:206
    Mass (Da):23,825
    Last modified:November 1, 1996 - v1
    Checksum:iCB8135083EAB8DDD
    GO
    Isoform 2 (identifier: Q13007-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-14: A → AS

    Show »
    Length:207
    Mass (Da):23,912
    Checksum:i17687A467B9CB551
    GO
    Isoform 3 (identifier: Q13007-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-14: A → AS
         101-153: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:154
    Mass (Da):17,751
    Checksum:i1AAAE1B2FD252B4E
    GO
    Isoform 4 (identifier: Q13007-4) [UniParc]FASTAAdd to Basket

    Also known as: mda-7s

    The sequence of this isoform differs from the canonical sequence as follows:
         15-206: RPFCPPLLAT...LTWMQKFYKL → SKLRITSRVP...YSGEHSNSWT

    Show »
    Length:63
    Mass (Da):7,347
    Checksum:iBEC50016AB595409
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti124 – 1241Y → H.2 Publications
    Corresponds to variant rs1150258 [ dbSNP | Ensembl ].
    VAR_011974
    Natural varianti125 – 1251H → R.1 Publication
    Corresponds to variant rs3093431 [ dbSNP | Ensembl ].
    VAR_013097
    Natural varianti131 – 1311V → L.1 Publication
    Corresponds to variant rs3093446 [ dbSNP | Ensembl ].
    VAR_013098

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei14 – 141A → AS in isoform 2 and isoform 3. 3 PublicationsVSP_042673
    Alternative sequencei15 – 206192RPFCP…KFYKL → SKLRITSRVPGCCSRRFCRT SRKKMRCFPSETVHTGGFCY SGEHSNSWT in isoform 4. 1 PublicationVSP_043915Add
    BLAST
    Alternative sequencei101 – 15353Missing in isoform 3. 1 PublicationVSP_042674Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16261 mRNA. Translation: AAA91780.1.
    AF276916 Genomic DNA. Translation: AAG41401.1.
    AF235005 Genomic DNA. Translation: AAK52589.1.
    AY237723 mRNA. Translation: AAO67513.1.
    AY062931 Genomic DNA. Translation: AAL34146.1.
    AY641441 mRNA. Translation: AAV52801.1.
    BT007156 mRNA. Translation: AAP35820.1.
    AC098935 Genomic DNA. No translation available.
    BC009681 mRNA. Translation: AAH09681.1.
    CCDSiCCDS1471.1. [Q13007-1]
    CCDS53465.1. [Q13007-2]
    CCDS53466.1. [Q13007-3]
    RefSeqiNP_001172085.1. NM_001185156.1. [Q13007-2]
    NP_001172086.1. NM_001185157.1. [Q13007-3]
    NP_001172087.1. NM_001185158.1. [Q13007-4]
    NP_006841.1. NM_006850.3. [Q13007-1]
    UniGeneiHs.58831.
    Hs.744273.

    Genome annotation databases

    EnsembliENST00000294984; ENSP00000294984; ENSG00000162892. [Q13007-1]
    ENST00000367093; ENSP00000356060; ENSG00000162892. [Q13007-3]
    ENST00000391929; ENSP00000375795; ENSG00000162892. [Q13007-2]
    GeneIDi11009.
    KEGGihsa:11009.
    UCSCiuc001hes.2. human. [Q13007-1]
    uc001heu.2. human. [Q13007-2]
    uc001hew.2. human. [Q13007-3]
    uc001hex.2. human. [Q13007-4]

    Polymorphism databases

    DMDMi2497340.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-24 entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16261 mRNA. Translation: AAA91780.1 .
    AF276916 Genomic DNA. Translation: AAG41401.1 .
    AF235005 Genomic DNA. Translation: AAK52589.1 .
    AY237723 mRNA. Translation: AAO67513.1 .
    AY062931 Genomic DNA. Translation: AAL34146.1 .
    AY641441 mRNA. Translation: AAV52801.1 .
    BT007156 mRNA. Translation: AAP35820.1 .
    AC098935 Genomic DNA. No translation available.
    BC009681 mRNA. Translation: AAH09681.1 .
    CCDSi CCDS1471.1. [Q13007-1 ]
    CCDS53465.1. [Q13007-2 ]
    CCDS53466.1. [Q13007-3 ]
    RefSeqi NP_001172085.1. NM_001185156.1. [Q13007-2 ]
    NP_001172086.1. NM_001185157.1. [Q13007-3 ]
    NP_001172087.1. NM_001185158.1. [Q13007-4 ]
    NP_006841.1. NM_006850.3. [Q13007-1 ]
    UniGenei Hs.58831.
    Hs.744273.

    3D structure databases

    ProteinModelPortali Q13007.
    SMRi Q13007. Positions 67-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116199. 5 interactions.
    IntActi Q13007. 3 interactions.
    STRINGi 9606.ENSP00000294984.

    PTM databases

    PhosphoSitei Q13007.

    Polymorphism databases

    DMDMi 2497340.

    Proteomic databases

    PaxDbi Q13007.
    PRIDEi Q13007.

    Protocols and materials databases

    DNASUi 11009.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294984 ; ENSP00000294984 ; ENSG00000162892 . [Q13007-1 ]
    ENST00000367093 ; ENSP00000356060 ; ENSG00000162892 . [Q13007-3 ]
    ENST00000391929 ; ENSP00000375795 ; ENSG00000162892 . [Q13007-2 ]
    GeneIDi 11009.
    KEGGi hsa:11009.
    UCSCi uc001hes.2. human. [Q13007-1 ]
    uc001heu.2. human. [Q13007-2 ]
    uc001hew.2. human. [Q13007-3 ]
    uc001hex.2. human. [Q13007-4 ]

    Organism-specific databases

    CTDi 11009.
    GeneCardsi GC01P207070.
    HGNCi HGNC:11346. IL24.
    HPAi CAB025972.
    HPA008252.
    MIMi 604136. gene.
    neXtProti NX_Q13007.
    PharmGKBi PA29825.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45557.
    HOGENOMi HOG000113033.
    HOVERGENi HBG098494.
    KOi K05444.
    OMAi VDILLTW.
    OrthoDBi EOG7060SK.
    PhylomeDBi Q13007.
    TreeFami TF333253.

    Enzyme and pathway databases

    SignaLinki Q13007.

    Miscellaneous databases

    GeneWikii Interleukin_24.
    GenomeRNAii 11009.
    NextBioi 41817.
    PROi Q13007.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13007.
    Bgeei Q13007.
    CleanExi HS_IL24.
    Genevestigatori Q13007.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    IPR020444. IL-24.
    [Graphical view ]
    PANTHERi PTHR11585. PTHR11585. 1 hit.
    PRINTSi PR01937. INTRLEUKIN24.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression."
      Jiang H., Lin J.J., Su Z.-Z., Goldstein N.I., Fisher P.B.
      Oncogene 11:2477-2486(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Melanoma.
    2. "The human MDA-7 gene."
      Peat J., Kube D., Eskdale J., Jueliger S., Gallagher G.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties."
      Huang E.Y., Madireddi M.T., Gopalkrishnan R.V., Leszczyniecka M., Su Z.-Z., Lebedeva I.V., Kang D., Jiang H., Lin J.J., Alexandre D., Chen Y., Vozhilla N., Mei M.X., Christiansen K.A., Sivo F., Goldstein N.I., Mhashilkar A.B., Chada S.
      , Huberman E., Pestka S., Fisher P.B.
      Oncogene 20:7051-7063(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-124.
      Tissue: Fibroblast.
    4. "Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma."
      Allen M., Pratscher B., Roka F., Krepler C., Wacheck V., Schofer C., Pehamberger H., Muller M., Lucas T.
      J. Invest. Dermatol. 123:583-588(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    5. SeattleSNPs variation discovery resource
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-124; ARG-125 AND LEU-131.
    6. "Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5."
      Allen M., Pratscher B., Krepler C., Frei K., Schofer C., Pehamberger H., Muller M., Lucas T.
      Int. J. Immunogenet. 32:375-378(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING.
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.
    10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 52-66.
    11. "The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice."
      Su Z.-Z., Madireddi M.T., Lin J.J., Young C.S.H., Kitada S., Reed J.C., Goldstein N.I., Fisher P.B.
      Proc. Natl. Acad. Sci. U.S.A. 95:14400-14405(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    12. "Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24."
      Tian H., Li L., Zhang B., Di J., Chen F., Li H., Liu J., Pei D., Zheng J.
      J. Interferon Cytokine Res. 32:575-582(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION AT LYS-122.

    Entry informationi

    Entry nameiIL24_HUMAN
    AccessioniPrimary (citable) accession number: Q13007
    Secondary accession number(s): Q2YHE5
    , Q53XZ7, Q5YLN8, Q96DB0, Q96KG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3