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Q13007 (IL24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 148. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-24

Short name=IL-24
Alternative name(s):
Melanoma differentiation-associated gene 7 protein
Short name=MDA-7
Suppression of tumorigenicity 16 protein
Gene names
Name:IL24
Synonyms:MDA7, ST16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Subcellular location

Secreted Potential.

Tissue specificity

Up-regulated in melanoma cells induced to terminally differentiate.

Post-translational modification

Ubiquitination at Lys-122 promotes proteasomal degradation.

Sequence similarities

Belongs to the IL-10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
Isopeptide bond
Ubl conjugation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Traceable author statement Ref.11. Source: ProtInc

cellular response to interleukin-4

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

serine phosphorylation of STAT3 protein

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q13007-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q13007-2)

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS
Isoform 3 (identifier: Q13007-3)

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS
     101-153: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q13007-4)

Also known as: mda-7s;

The sequence of this isoform differs from the canonical sequence as follows:
     15-206: RPFCPPLLAT...LTWMQKFYKL → SKLRITSRVP...YSGEHSNSWT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5151 Ref.10
Chain52 – 206155Interleukin-24
PRO_0000015386

Amino acid modifications

Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Cross-link122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.12

Natural variations

Alternative sequence141A → AS in isoform 2 and isoform 3.
VSP_042673
Alternative sequence15 – 206192RPFCP…KFYKL → SKLRITSRVPGCCSRRFCRT SRKKMRCFPSETVHTGGFCY SGEHSNSWT in isoform 4.
VSP_043915
Alternative sequence101 – 15353Missing in isoform 3.
VSP_042674
Natural variant1241Y → H. Ref.3 Ref.5
Corresponds to variant rs1150258 [ dbSNP | Ensembl ].
VAR_011974
Natural variant1251H → R. Ref.5
Corresponds to variant rs3093431 [ dbSNP | Ensembl ].
VAR_013097
Natural variant1311V → L. Ref.5
Corresponds to variant rs3093446 [ dbSNP | Ensembl ].
VAR_013098

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CB8135083EAB8DDD

FASTA20623,825
        10         20         30         40         50         60 
MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ GQEFHFGPCQ 

        70         80         90        100        110        120 
VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV SDAESCYLVH TLLEFYLKTV 

       130        140        150        160        170        180 
FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ LQPSQENEMF SIRDSAHRRF LLFRRAFKQL 

       190        200 
DVEAALTKAL GEVDILLTWM QKFYKL 

« Hide

Isoform 2 [UniParc].

Checksum: 17687A467B9CB551
Show »

FASTA20723,912
Isoform 3 [UniParc].

Checksum: 1AAAE1B2FD252B4E
Show »

FASTA15417,751
Isoform 4 (mda-7s) [UniParc].

Checksum: BEC50016AB595409
Show »

FASTA637,347

References

« Hide 'large scale' references
[1]"Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression."
Jiang H., Lin J.J., Su Z.-Z., Goldstein N.I., Fisher P.B.
Oncogene 11:2477-2486(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Melanoma.
[2]"The human MDA-7 gene."
Peat J., Kube D., Eskdale J., Jueliger S., Gallagher G.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties."
Huang E.Y., Madireddi M.T., Gopalkrishnan R.V., Leszczyniecka M., Su Z.-Z., Lebedeva I.V., Kang D., Jiang H., Lin J.J., Alexandre D., Chen Y., Vozhilla N., Mei M.X., Christiansen K.A., Sivo F., Goldstein N.I., Mhashilkar A.B., Chada S. expand/collapse author list , Huberman E., Pestka S., Fisher P.B.
Oncogene 20:7051-7063(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-124.
Tissue: Fibroblast.
[4]"Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma."
Allen M., Pratscher B., Roka F., Krepler C., Wacheck V., Schofer C., Pehamberger H., Muller M., Lucas T.
J. Invest. Dermatol. 123:583-588(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[5]SeattleSNPs variation discovery resource
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-124; ARG-125 AND LEU-131.
[6]"Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5."
Allen M., Pratscher B., Krepler C., Frei K., Schofer C., Pehamberger H., Muller M., Lucas T.
Int. J. Immunogenet. 32:375-378(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING.
[7]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[8]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung.
[10]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 52-66.
[11]"The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice."
Su Z.-Z., Madireddi M.T., Lin J.J., Young C.S.H., Kitada S., Reed J.C., Goldstein N.I., Fisher P.B.
Proc. Natl. Acad. Sci. U.S.A. 95:14400-14405(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[12]"Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24."
Tian H., Li L., Zhang B., Di J., Chen F., Li H., Liu J., Pei D., Zheng J.
J. Interferon Cytokine Res. 32:575-582(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION AT LYS-122.
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-24 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U16261 mRNA. Translation: AAA91780.1.
AF276916 Genomic DNA. Translation: AAG41401.1.
AF235005 Genomic DNA. Translation: AAK52589.1.
AY237723 mRNA. Translation: AAO67513.1.
AY062931 Genomic DNA. Translation: AAL34146.1.
AY641441 mRNA. Translation: AAV52801.1.
BT007156 mRNA. Translation: AAP35820.1.
AC098935 Genomic DNA. No translation available.
BC009681 mRNA. Translation: AAH09681.1.
CCDSCCDS1471.1. [Q13007-1]
CCDS53465.1. [Q13007-2]
CCDS53466.1. [Q13007-3]
RefSeqNP_001172085.1. NM_001185156.1. [Q13007-2]
NP_001172086.1. NM_001185157.1. [Q13007-3]
NP_001172087.1. NM_001185158.1. [Q13007-4]
NP_006841.1. NM_006850.3. [Q13007-1]
UniGeneHs.58831.
Hs.744273.

3D structure databases

ProteinModelPortalQ13007.
SMRQ13007. Positions 67-202.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116199. 5 interactions.
IntActQ13007. 3 interactions.
STRING9606.ENSP00000294984.

PTM databases

PhosphoSiteQ13007.

Polymorphism databases

DMDM2497340.

Proteomic databases

PaxDbQ13007.
PRIDEQ13007.

Protocols and materials databases

DNASU11009.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294984; ENSP00000294984; ENSG00000162892. [Q13007-1]
ENST00000367093; ENSP00000356060; ENSG00000162892. [Q13007-3]
ENST00000391929; ENSP00000375795; ENSG00000162892. [Q13007-2]
GeneID11009.
KEGGhsa:11009.
UCSCuc001hes.2. human. [Q13007-1]
uc001heu.2. human. [Q13007-2]
uc001hew.2. human. [Q13007-3]
uc001hex.2. human. [Q13007-4]

Organism-specific databases

CTD11009.
GeneCardsGC01P207070.
HGNCHGNC:11346. IL24.
HPACAB025972.
HPA008252.
MIM604136. gene.
neXtProtNX_Q13007.
PharmGKBPA29825.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45557.
HOGENOMHOG000113033.
HOVERGENHBG098494.
KOK05444.
OMAVDILLTW.
OrthoDBEOG7060SK.
PhylomeDBQ13007.
TreeFamTF333253.

Enzyme and pathway databases

SignaLinkQ13007.

Gene expression databases

ArrayExpressQ13007.
BgeeQ13007.
CleanExHS_IL24.
GenevestigatorQ13007.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERPTHR11585. PTHR11585. 1 hit.
PRINTSPR01937. INTRLEUKIN24.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiInterleukin_24.
GenomeRNAi11009.
NextBio41817.
PROQ13007.
SOURCESearch...

Entry information

Entry nameIL24_HUMAN
AccessionPrimary (citable) accession number: Q13007
Secondary accession number(s): Q2YHE5 expand/collapse secondary AC list , Q53XZ7, Q5YLN8, Q96DB0, Q96KG4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM