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Q13007

- IL24_HUMAN

UniProt

Q13007 - IL24_HUMAN

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Protein

Interleukin-24

Gene

IL24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

GO - Biological processi

  1. apoptotic process Source: ProtInc
  2. cellular response to interleukin-4 Source: Ensembl
  3. cellular response to lipopolysaccharide Source: Ensembl
  4. negative regulation of apoptotic process Source: Ensembl
  5. negative regulation of cell migration Source: Ensembl
  6. negative regulation of cell proliferation Source: Ensembl
  7. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  8. positive regulation of apoptotic process Source: Ensembl
  9. positive regulation of cell proliferation Source: Ensembl
  10. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  11. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  12. serine phosphorylation of STAT3 protein Source: Ensembl
  13. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

SignaLinkiQ13007.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-24
Short name:
IL-24
Alternative name(s):
Melanoma differentiation-associated gene 7 protein
Short name:
MDA-7
Suppression of tumorigenicity 16 protein
Gene namesi
Name:IL24
Synonyms:MDA7, ST16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11346. IL24.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 51511 PublicationAdd
BLAST
Chaini52 – 206155Interleukin-24PRO_0000015386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Cross-linki122 – 122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Ubiquitination at Lys-122 promotes proteasomal degradation.1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ13007.
PRIDEiQ13007.

PTM databases

PhosphoSiteiQ13007.

Expressioni

Tissue specificityi

Up-regulated in melanoma cells induced to terminally differentiate.

Gene expression databases

BgeeiQ13007.
CleanExiHS_IL24.
ExpressionAtlasiQ13007. baseline and differential.
GenevestigatoriQ13007.

Organism-specific databases

HPAiCAB025972.
HPA008252.

Interactioni

Protein-protein interaction databases

BioGridi116199. 5 interactions.
IntActiQ13007. 3 interactions.
STRINGi9606.ENSP00000294984.

Structurei

3D structure databases

ProteinModelPortaliQ13007.
SMRiQ13007. Positions 67-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45557.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG098494.
InParanoidiQ13007.
KOiK05444.
OMAiVDILLTW.
OrthoDBiEOG7060SK.
PhylomeDBiQ13007.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PRINTSiPR01937. INTRLEUKIN24.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13007-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ
60 70 80 90 100
GQEFHFGPCQ VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV
110 120 130 140 150
SDAESCYLVH TLLEFYLKTV FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ
160 170 180 190 200
LQPSQENEMF SIRDSAHRRF LLFRRAFKQL DVEAALTKAL GEVDILLTWM

QKFYKL
Length:206
Mass (Da):23,825
Last modified:November 1, 1996 - v1
Checksum:iCB8135083EAB8DDD
GO
Isoform 2 (identifier: Q13007-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS

Show »
Length:207
Mass (Da):23,912
Checksum:i17687A467B9CB551
GO
Isoform 3 (identifier: Q13007-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS
     101-153: Missing.

Note: No experimental confirmation available.

Show »
Length:154
Mass (Da):17,751
Checksum:i1AAAE1B2FD252B4E
GO
Isoform 4 (identifier: Q13007-4) [UniParc]FASTAAdd to Basket

Also known as: mda-7s

The sequence of this isoform differs from the canonical sequence as follows:
     15-206: RPFCPPLLAT...LTWMQKFYKL → SKLRITSRVP...YSGEHSNSWT

Show »
Length:63
Mass (Da):7,347
Checksum:iBEC50016AB595409
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241Y → H.2 Publications
Corresponds to variant rs1150258 [ dbSNP | Ensembl ].
VAR_011974
Natural varianti125 – 1251H → R.1 Publication
Corresponds to variant rs3093431 [ dbSNP | Ensembl ].
VAR_013097
Natural varianti131 – 1311V → L.1 Publication
Corresponds to variant rs3093446 [ dbSNP | Ensembl ].
VAR_013098

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei14 – 141A → AS in isoform 2 and isoform 3. 3 PublicationsVSP_042673
Alternative sequencei15 – 206192RPFCP…KFYKL → SKLRITSRVPGCCSRRFCRT SRKKMRCFPSETVHTGGFCY SGEHSNSWT in isoform 4. 1 PublicationVSP_043915Add
BLAST
Alternative sequencei101 – 15353Missing in isoform 3. 1 PublicationVSP_042674Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16261 mRNA. Translation: AAA91780.1.
AF276916 Genomic DNA. Translation: AAG41401.1.
AF235005 Genomic DNA. Translation: AAK52589.1.
AY237723 mRNA. Translation: AAO67513.1.
AY062931 Genomic DNA. Translation: AAL34146.1.
AY641441 mRNA. Translation: AAV52801.1.
BT007156 mRNA. Translation: AAP35820.1.
AC098935 Genomic DNA. No translation available.
BC009681 mRNA. Translation: AAH09681.1.
CCDSiCCDS1471.1. [Q13007-1]
CCDS53465.1. [Q13007-2]
CCDS53466.1. [Q13007-3]
CCDS73021.1. [Q13007-4]
RefSeqiNP_001172085.1. NM_001185156.1. [Q13007-2]
NP_001172086.1. NM_001185157.1. [Q13007-3]
NP_001172087.1. NM_001185158.1. [Q13007-4]
NP_006841.1. NM_006850.3. [Q13007-1]
UniGeneiHs.58831.
Hs.744273.

Genome annotation databases

EnsembliENST00000294984; ENSP00000294984; ENSG00000162892. [Q13007-1]
ENST00000367093; ENSP00000356060; ENSG00000162892. [Q13007-3]
ENST00000391929; ENSP00000375795; ENSG00000162892. [Q13007-2]
ENST00000611909; ENSP00000484900; ENSG00000162892. [Q13007-4]
GeneIDi11009.
KEGGihsa:11009.
UCSCiuc001hes.2. human. [Q13007-1]
uc001heu.2. human. [Q13007-2]
uc001hew.2. human. [Q13007-3]
uc001hex.2. human. [Q13007-4]

Polymorphism databases

DMDMi2497340.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-24 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U16261 mRNA. Translation: AAA91780.1 .
AF276916 Genomic DNA. Translation: AAG41401.1 .
AF235005 Genomic DNA. Translation: AAK52589.1 .
AY237723 mRNA. Translation: AAO67513.1 .
AY062931 Genomic DNA. Translation: AAL34146.1 .
AY641441 mRNA. Translation: AAV52801.1 .
BT007156 mRNA. Translation: AAP35820.1 .
AC098935 Genomic DNA. No translation available.
BC009681 mRNA. Translation: AAH09681.1 .
CCDSi CCDS1471.1. [Q13007-1 ]
CCDS53465.1. [Q13007-2 ]
CCDS53466.1. [Q13007-3 ]
CCDS73021.1. [Q13007-4 ]
RefSeqi NP_001172085.1. NM_001185156.1. [Q13007-2 ]
NP_001172086.1. NM_001185157.1. [Q13007-3 ]
NP_001172087.1. NM_001185158.1. [Q13007-4 ]
NP_006841.1. NM_006850.3. [Q13007-1 ]
UniGenei Hs.58831.
Hs.744273.

3D structure databases

ProteinModelPortali Q13007.
SMRi Q13007. Positions 67-202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116199. 5 interactions.
IntActi Q13007. 3 interactions.
STRINGi 9606.ENSP00000294984.

PTM databases

PhosphoSitei Q13007.

Polymorphism databases

DMDMi 2497340.

Proteomic databases

PaxDbi Q13007.
PRIDEi Q13007.

Protocols and materials databases

DNASUi 11009.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294984 ; ENSP00000294984 ; ENSG00000162892 . [Q13007-1 ]
ENST00000367093 ; ENSP00000356060 ; ENSG00000162892 . [Q13007-3 ]
ENST00000391929 ; ENSP00000375795 ; ENSG00000162892 . [Q13007-2 ]
ENST00000611909 ; ENSP00000484900 ; ENSG00000162892 . [Q13007-4 ]
GeneIDi 11009.
KEGGi hsa:11009.
UCSCi uc001hes.2. human. [Q13007-1 ]
uc001heu.2. human. [Q13007-2 ]
uc001hew.2. human. [Q13007-3 ]
uc001hex.2. human. [Q13007-4 ]

Organism-specific databases

CTDi 11009.
GeneCardsi GC01P207070.
HGNCi HGNC:11346. IL24.
HPAi CAB025972.
HPA008252.
MIMi 604136. gene.
neXtProti NX_Q13007.
PharmGKBi PA29825.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45557.
GeneTreei ENSGT00410000025637.
HOGENOMi HOG000113033.
HOVERGENi HBG098494.
InParanoidi Q13007.
KOi K05444.
OMAi VDILLTW.
OrthoDBi EOG7060SK.
PhylomeDBi Q13007.
TreeFami TF333253.

Enzyme and pathway databases

SignaLinki Q13007.

Miscellaneous databases

GeneWikii Interleukin_24.
GenomeRNAii 11009.
NextBioi 41817.
PROi Q13007.
SOURCEi Search...

Gene expression databases

Bgeei Q13007.
CleanExi HS_IL24.
ExpressionAtlasi Q13007. baseline and differential.
Genevestigatori Q13007.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view ]
PANTHERi PTHR11585. PTHR11585. 1 hit.
PRINTSi PR01937. INTRLEUKIN24.
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression."
    Jiang H., Lin J.J., Su Z.-Z., Goldstein N.I., Fisher P.B.
    Oncogene 11:2477-2486(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Melanoma.
  2. "The human MDA-7 gene."
    Peat J., Kube D., Eskdale J., Jueliger S., Gallagher G.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties."
    Huang E.Y., Madireddi M.T., Gopalkrishnan R.V., Leszczyniecka M., Su Z.-Z., Lebedeva I.V., Kang D., Jiang H., Lin J.J., Alexandre D., Chen Y., Vozhilla N., Mei M.X., Christiansen K.A., Sivo F., Goldstein N.I., Mhashilkar A.B., Chada S.
    , Huberman E., Pestka S., Fisher P.B.
    Oncogene 20:7051-7063(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-124.
    Tissue: Fibroblast.
  4. "Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma."
    Allen M., Pratscher B., Roka F., Krepler C., Wacheck V., Schofer C., Pehamberger H., Muller M., Lucas T.
    J. Invest. Dermatol. 123:583-588(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  5. SeattleSNPs variation discovery resource
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-124; ARG-125 AND LEU-131.
  6. "Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5."
    Allen M., Pratscher B., Krepler C., Frei K., Schofer C., Pehamberger H., Muller M., Lucas T.
    Int. J. Immunogenet. 32:375-378(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 52-66.
  11. "The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice."
    Su Z.-Z., Madireddi M.T., Lin J.J., Young C.S.H., Kitada S., Reed J.C., Goldstein N.I., Fisher P.B.
    Proc. Natl. Acad. Sci. U.S.A. 95:14400-14405(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  12. "Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24."
    Tian H., Li L., Zhang B., Di J., Chen F., Li H., Liu J., Pei D., Zheng J.
    J. Interferon Cytokine Res. 32:575-582(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-122.

Entry informationi

Entry nameiIL24_HUMAN
AccessioniPrimary (citable) accession number: Q13007
Secondary accession number(s): Q2YHE5
, Q53XZ7, Q5YLN8, Q96DB0, Q96KG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3