Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-24

Gene

IL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162892-MONOMER.
ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ13007.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-24
Short name:
IL-24
Alternative name(s):
Melanoma differentiation-associated gene 7 protein
Short name:
MDA-7
Suppression of tumorigenicity 16 protein
Gene namesi
Name:IL24
Synonyms:MDA7, ST16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11346. IL24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11009.
OpenTargetsiENSG00000162892.
PharmGKBiPA29825.

Polymorphism and mutation databases

BioMutaiIL24.
DMDMi2497340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 511 PublicationAdd BLAST51
ChainiPRO_000001538652 – 206Interleukin-24Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Ubiquitination at Lys-122 promotes proteasomal degradation.1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ13007.
PeptideAtlasiQ13007.
PRIDEiQ13007.

PTM databases

iPTMnetiQ13007.
PhosphoSitePlusiQ13007.

Expressioni

Tissue specificityi

Up-regulated in melanoma cells induced to terminally differentiate.

Gene expression databases

BgeeiENSG00000162892.
CleanExiHS_IL24.
ExpressionAtlasiQ13007. baseline and differential.
GenevisibleiQ13007. HS.

Organism-specific databases

HPAiCAB025972.
HPA008252.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATMQ133152EBI-3915542,EBI-495465
CHEK2O960173EBI-3915542,EBI-1180783
PARP1P098742EBI-3915542,EBI-355676
RAD51Q066092EBI-3915542,EBI-297202

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116199. 26 interactors.
IntActiQ13007. 25 interactors.
STRINGi9606.ENSP00000375795.

Structurei

3D structure databases

ProteinModelPortaliQ13007.
SMRiQ13007.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZYS. Eukaryota.
ENOG41119SI. LUCA.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG098494.
InParanoidiQ13007.
KOiK05444.
OMAiWEAFWAV.
OrthoDBiEOG091G0Q0Q.
PhylomeDBiQ13007.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PRINTSiPR01937. INTRLEUKIN24.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13007-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ
60 70 80 90 100
GQEFHFGPCQ VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV
110 120 130 140 150
SDAESCYLVH TLLEFYLKTV FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ
160 170 180 190 200
LQPSQENEMF SIRDSAHRRF LLFRRAFKQL DVEAALTKAL GEVDILLTWM

QKFYKL
Length:206
Mass (Da):23,825
Last modified:November 1, 1996 - v1
Checksum:iCB8135083EAB8DDD
GO
Isoform 2 (identifier: Q13007-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS

Show »
Length:207
Mass (Da):23,912
Checksum:i17687A467B9CB551
GO
Isoform 3 (identifier: Q13007-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS
     101-153: Missing.

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,751
Checksum:i1AAAE1B2FD252B4E
GO
Isoform 4 (identifier: Q13007-4) [UniParc]FASTAAdd to basket
Also known as: mda-7s

The sequence of this isoform differs from the canonical sequence as follows:
     15-206: RPFCPPLLAT...LTWMQKFYKL → SKLRITSRVP...YSGEHSNSWT

Show »
Length:63
Mass (Da):7,347
Checksum:iBEC50016AB595409
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011974124Y → H.2 PublicationsCorresponds to variant rs1150258dbSNPEnsembl.1
Natural variantiVAR_013097125H → R.1 PublicationCorresponds to variant rs3093431dbSNPEnsembl.1
Natural variantiVAR_013098131V → L.1 PublicationCorresponds to variant rs3093446dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04267314A → AS in isoform 2 and isoform 3. 3 Publications1
Alternative sequenceiVSP_04391515 – 206RPFCP…KFYKL → SKLRITSRVPGCCSRRFCRT SRKKMRCFPSETVHTGGFCY SGEHSNSWT in isoform 4. 1 PublicationAdd BLAST192
Alternative sequenceiVSP_042674101 – 153Missing in isoform 3. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16261 mRNA. Translation: AAA91780.1.
AF276916 Genomic DNA. Translation: AAG41401.1.
AF235005 Genomic DNA. Translation: AAK52589.1.
AY237723 mRNA. Translation: AAO67513.1.
AY062931 Genomic DNA. Translation: AAL34146.1.
AY641441 mRNA. Translation: AAV52801.1.
BT007156 mRNA. Translation: AAP35820.1.
AC098935 Genomic DNA. No translation available.
BC009681 mRNA. Translation: AAH09681.1.
CCDSiCCDS1471.1. [Q13007-1]
CCDS53465.1. [Q13007-2]
CCDS53466.1. [Q13007-3]
CCDS73021.1. [Q13007-4]
RefSeqiNP_001172085.1. NM_001185156.1. [Q13007-2]
NP_001172086.1. NM_001185157.1. [Q13007-3]
NP_001172087.1. NM_001185158.1. [Q13007-4]
NP_006841.1. NM_006850.3. [Q13007-1]
UniGeneiHs.58831.
Hs.744273.

Genome annotation databases

EnsembliENST00000294984; ENSP00000294984; ENSG00000162892. [Q13007-1]
ENST00000367093; ENSP00000356060; ENSG00000162892. [Q13007-3]
ENST00000391929; ENSP00000375795; ENSG00000162892. [Q13007-2]
ENST00000611909; ENSP00000484900; ENSG00000162892. [Q13007-4]
GeneIDi11009.
KEGGihsa:11009.
UCSCiuc001hes.3. human. [Q13007-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-24 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16261 mRNA. Translation: AAA91780.1.
AF276916 Genomic DNA. Translation: AAG41401.1.
AF235005 Genomic DNA. Translation: AAK52589.1.
AY237723 mRNA. Translation: AAO67513.1.
AY062931 Genomic DNA. Translation: AAL34146.1.
AY641441 mRNA. Translation: AAV52801.1.
BT007156 mRNA. Translation: AAP35820.1.
AC098935 Genomic DNA. No translation available.
BC009681 mRNA. Translation: AAH09681.1.
CCDSiCCDS1471.1. [Q13007-1]
CCDS53465.1. [Q13007-2]
CCDS53466.1. [Q13007-3]
CCDS73021.1. [Q13007-4]
RefSeqiNP_001172085.1. NM_001185156.1. [Q13007-2]
NP_001172086.1. NM_001185157.1. [Q13007-3]
NP_001172087.1. NM_001185158.1. [Q13007-4]
NP_006841.1. NM_006850.3. [Q13007-1]
UniGeneiHs.58831.
Hs.744273.

3D structure databases

ProteinModelPortaliQ13007.
SMRiQ13007.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116199. 26 interactors.
IntActiQ13007. 25 interactors.
STRINGi9606.ENSP00000375795.

PTM databases

iPTMnetiQ13007.
PhosphoSitePlusiQ13007.

Polymorphism and mutation databases

BioMutaiIL24.
DMDMi2497340.

Proteomic databases

PaxDbiQ13007.
PeptideAtlasiQ13007.
PRIDEiQ13007.

Protocols and materials databases

DNASUi11009.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294984; ENSP00000294984; ENSG00000162892. [Q13007-1]
ENST00000367093; ENSP00000356060; ENSG00000162892. [Q13007-3]
ENST00000391929; ENSP00000375795; ENSG00000162892. [Q13007-2]
ENST00000611909; ENSP00000484900; ENSG00000162892. [Q13007-4]
GeneIDi11009.
KEGGihsa:11009.
UCSCiuc001hes.3. human. [Q13007-1]

Organism-specific databases

CTDi11009.
DisGeNETi11009.
GeneCardsiIL24.
HGNCiHGNC:11346. IL24.
HPAiCAB025972.
HPA008252.
MIMi604136. gene.
neXtProtiNX_Q13007.
OpenTargetsiENSG00000162892.
PharmGKBiPA29825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZYS. Eukaryota.
ENOG41119SI. LUCA.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG098494.
InParanoidiQ13007.
KOiK05444.
OMAiWEAFWAV.
OrthoDBiEOG091G0Q0Q.
PhylomeDBiQ13007.
TreeFamiTF333253.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162892-MONOMER.
ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ13007.

Miscellaneous databases

GeneWikiiInterleukin_24.
GenomeRNAii11009.
PROiQ13007.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162892.
CleanExiHS_IL24.
ExpressionAtlasiQ13007. baseline and differential.
GenevisibleiQ13007. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PRINTSiPR01937. INTRLEUKIN24.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL24_HUMAN
AccessioniPrimary (citable) accession number: Q13007
Secondary accession number(s): Q2YHE5
, Q53XZ7, Q5YLN8, Q96DB0, Q96KG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.