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Protein

Glutamate receptor ionotropic, kainate 3

Gene

GRIK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei520GlutamateBy similarity1
Binding sitei525GlutamateBy similarity1
Binding sitei739GlutamateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163873-MONOMER.
ReactomeiR-HSA-451308. Activation of Ca-permeable Kainate Receptor.
R-HSA-500657. Presynaptic function of Kainate receptors.
SignaLinkiQ13003.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 3
Short name:
GluK3
Alternative name(s):
Excitatory amino acid receptor 5
Short name:
EAA5
Glutamate receptor 7
Short name:
GluR-7
Short name:
GluR7
Gene namesi
Name:GRIK3
Synonyms:GLUR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4581. GRIK3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 563ExtracellularSequence analysisAdd BLAST532
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 636CytoplasmicSequence analysisAdd BLAST52
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 820ExtracellularSequence analysisAdd BLAST163
Transmembranei821 – 841HelicalSequence analysisAdd BLAST21
Topological domaini842 – 919CytoplasmicSequence analysisAdd BLAST78

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2899.
OpenTargetsiENSG00000163873.
PharmGKBiPA28975.

Chemistry databases

ChEMBLiCHEMBL3684.
GuidetoPHARMACOLOGYi452.

Polymorphism and mutation databases

BioMutaiGRIK3.
DMDMi212276502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001154732 – 919Glutamate receptor ionotropic, kainate 3Add BLAST888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 350By similarity
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Glycosylationi415N-linked (GlcNAc...)Sequence analysis1
Glycosylationi426N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1
Modified residuei869PhosphoserineBy similarity1
Cross-linki887Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ13003.
PeptideAtlasiQ13003.
PRIDEiQ13003.

PTM databases

iPTMnetiQ13003.
PhosphoSitePlusiQ13003.

Expressioni

Gene expression databases

BgeeiENSG00000163873.
CleanExiHS_GRIK3.
GenevisibleiQ13003. HS.

Organism-specific databases

HPAiHPA014709.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109156. 2 interactors.
STRINGi9606.ENSP00000362183.

Chemistry databases

BindingDBiQ13003.

Structurei

3D structure databases

ProteinModelPortaliQ13003.
SMRiQ13003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni690 – 692Glutamate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ13003.
KOiK05203.
OMAiHILKQAM.
OrthoDBiEOG091G02LN.
PhylomeDBiQ13003.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAPWRRLRS LVWEYWAGLL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA
60 70 80 90 100
QVMNAEEHAF RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD
110 120 130 140 150
QLALGVVAIF GPSQGSCTNA VQSICNALEV PHIQLRWKHH PLDNKDTFYV
160 170 180 190 200
NLYPDYASLS HAILDLVQYL KWRSATVVYD DSTGLIRLQE LIMAPSRYNI
210 220 230 240 250
RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ ILKQAMAMGM
260 270 280 290 300
MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWS
310 320 330 340 350
MERLQAAPRS ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC
360 370 380 390 400
HRHKAWRFGG RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED
410 420 430 440 450
GLEKVGVWSP ADGLNITEVA KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR
460 470 480 490 500
KSDRTLYGND RFEGYCIDLL KELAHILGFS YEIRLVEDGK YGAQDDKGQW
510 520 530 540 550
NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV SILYRKPNGT
560 570 580 590 600
NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG
610 620 630 640 650
SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII
660 670 680 690 700
SSYTANLAAF LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK
710 720 730 740 750
ISTFEKMWAF MSSKPSALVK NNEEGIQRAL TADYALLMES TTIEYVTQRN
760 770 780 790 800
CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT IAILQLQEED KLHIMKEKWW
810 820 830 840 850
RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV GEFVYKLRKT
860 870 880 890 900
AEREQRSFCS TVADEIRFSL TCQRRVKHKP QPPMMVKTDA VINMHTFNDR
910
RLPGKDSMAC STSLAPVFP
Length:919
Mass (Da):104,037
Last modified:November 4, 2008 - v3
Checksum:i0F68F6CF33E4CE71
GO
Isoform 2 (identifier: Q13003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     856-919: RSFCSTVADE...CSTSLAPVFP → VSLRAWSLHRMGNGDSR

Show »
Length:872
Mass (Da):98,727
Checksum:i6479BC2B92321129
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303R → L in AAB30157 (PubMed:16710414).Curated1
Sequence conflicti627E → V in AAB60407 (PubMed:7719709).Curated1
Sequence conflicti713S → R in AAB60407 (PubMed:7719709).Curated1

RNA editingi

Edited at position 352.1 Publication
Partially edited.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035695215R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs755366301dbSNPEnsembl.1
Natural variantiVAR_000308310S → A.2 PublicationsCorresponds to variant rs6691840dbSNPEnsembl.1
Natural variantiVAR_000309352R → Q in RNA edited version. 1
Natural variantiVAR_035696391D → H in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056588856 – 919RSFCS…APVFP → VSLRAWSLHRMGNGDSR in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16127 mRNA. Translation: AAB60407.1.
U16128 Genomic DNA. Translation: AAC50421.1.
AJ249210 mRNA. Translation: CAC80548.1.
AL355386, AC117945 Genomic DNA. Translation: CAI19119.1.
AL591883 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07350.1.
CH471059 Genomic DNA. Translation: EAX07351.1.
S69349 Genomic DNA. Translation: AAB30157.1.
CCDSiCCDS416.1. [Q13003-1]
PIRiI59604.
RefSeqiNP_000822.2. NM_000831.3. [Q13003-1]
UniGeneiHs.128848.

Genome annotation databases

EnsembliENST00000373091; ENSP00000362183; ENSG00000163873. [Q13003-1]
ENST00000373093; ENSP00000362185; ENSG00000163873. [Q13003-2]
GeneIDi2899.
KEGGihsa:2899.
UCSCiuc001caz.3. human. [Q13003-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16127 mRNA. Translation: AAB60407.1.
U16128 Genomic DNA. Translation: AAC50421.1.
AJ249210 mRNA. Translation: CAC80548.1.
AL355386, AC117945 Genomic DNA. Translation: CAI19119.1.
AL591883 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07350.1.
CH471059 Genomic DNA. Translation: EAX07351.1.
S69349 Genomic DNA. Translation: AAB30157.1.
CCDSiCCDS416.1. [Q13003-1]
PIRiI59604.
RefSeqiNP_000822.2. NM_000831.3. [Q13003-1]
UniGeneiHs.128848.

3D structure databases

ProteinModelPortaliQ13003.
SMRiQ13003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109156. 2 interactors.
STRINGi9606.ENSP00000362183.

Chemistry databases

BindingDBiQ13003.
ChEMBLiCHEMBL3684.
GuidetoPHARMACOLOGYi452.

PTM databases

iPTMnetiQ13003.
PhosphoSitePlusiQ13003.

Polymorphism and mutation databases

BioMutaiGRIK3.
DMDMi212276502.

Proteomic databases

PaxDbiQ13003.
PeptideAtlasiQ13003.
PRIDEiQ13003.

Protocols and materials databases

DNASUi2899.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373091; ENSP00000362183; ENSG00000163873. [Q13003-1]
ENST00000373093; ENSP00000362185; ENSG00000163873. [Q13003-2]
GeneIDi2899.
KEGGihsa:2899.
UCSCiuc001caz.3. human. [Q13003-1]

Organism-specific databases

CTDi2899.
DisGeNETi2899.
GeneCardsiGRIK3.
H-InvDBHIX0028621.
HGNCiHGNC:4581. GRIK3.
HPAiHPA014709.
MIMi138243. gene.
neXtProtiNX_Q13003.
OpenTargetsiENSG00000163873.
PharmGKBiPA28975.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ13003.
KOiK05203.
OMAiHILKQAM.
OrthoDBiEOG091G02LN.
PhylomeDBiQ13003.
TreeFamiTF334668.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163873-MONOMER.
ReactomeiR-HSA-451308. Activation of Ca-permeable Kainate Receptor.
R-HSA-500657. Presynaptic function of Kainate receptors.
SignaLinkiQ13003.

Miscellaneous databases

ChiTaRSiGRIK3. human.
GeneWikiiGRIK3.
GenomeRNAii2899.
PROiQ13003.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163873.
CleanExiHS_GRIK3.
GenevisibleiQ13003. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRIK3_HUMAN
AccessioniPrimary (citable) accession number: Q13003
Secondary accession number(s): A9Z1Z8
, B1AMS6, Q13004, Q16136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.