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Q13003

- GRIK3_HUMAN

UniProt

Q13003 - GRIK3_HUMAN

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Protein

Glutamate receptor ionotropic, kainate 3

Gene

GRIK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei520 – 5201GlutamateBy similarity
Binding sitei525 – 5251GlutamateBy similarity
Binding sitei739 – 7391GlutamateBy similarity

GO - Molecular functioni

  1. adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Source: UniProtKB
  2. extracellular-glutamate-gated ion channel activity Source: RefGenome
  3. glutamate receptor activity Source: UniProtKB
  4. ionotropic glutamate receptor activity Source: UniProtKB
  5. kainate selective glutamate receptor activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: GOC
  2. glutamate receptor signaling pathway Source: UniProtKB
  3. G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  4. ionotropic glutamate receptor signaling pathway Source: GOC
  5. ion transmembrane transport Source: GOC
  6. negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
  7. regulation of membrane potential Source: UniProtKB
  8. synaptic transmission Source: Reactome
  9. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_21254. Presynaptic function of Kainate receptors.
REACT_21346. Activation of Ca-permeable Kainate Receptor.
SignaLinkiQ13003.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 3
Short name:
GluK3
Alternative name(s):
Excitatory amino acid receptor 5
Short name:
EAA5
Glutamate receptor 7
Short name:
GluR-7
Short name:
GluR7
Gene namesi
Name:GRIK3
Synonyms:GLUR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4581. GRIK3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 563532ExtracellularSequence AnalysisAdd
BLAST
Transmembranei564 – 58421HelicalSequence AnalysisAdd
BLAST
Topological domaini585 – 63652CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei637 – 65721HelicalSequence AnalysisAdd
BLAST
Topological domaini658 – 820163ExtracellularSequence AnalysisAdd
BLAST
Transmembranei821 – 84121HelicalSequence AnalysisAdd
BLAST
Topological domaini842 – 91978CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. dendrite Source: UniProtKB
  4. dendrite cytoplasm Source: UniProtKB
  5. integral component of plasma membrane Source: UniProtKB
  6. kainate selective glutamate receptor complex Source: RefGenome
  7. perikaryon Source: UniProtKB
  8. plasma membrane Source: Reactome
  9. postsynaptic membrane Source: RefGenome
  10. presynaptic membrane Source: RefGenome
  11. terminal bouton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 919888Glutamate receptor ionotropic, kainate 3PRO_0000011547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 350By similarity
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13003.
PRIDEiQ13003.

PTM databases

PhosphoSiteiQ13003.

Expressioni

Gene expression databases

BgeeiQ13003.
CleanExiHS_GRIK3.
ExpressionAtlasiQ13003. baseline.
GenevestigatoriQ13003.

Organism-specific databases

HPAiHPA014709.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi109156. 4 interactions.
STRINGi9606.ENSP00000362183.

Structurei

3D structure databases

ProteinModelPortaliQ13003.
SMRiQ13003. Positions 34-845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni690 – 6923Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316680.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ13003.
KOiK05203.
OMAiEEQAFRF.
OrthoDBiEOG71G9W6.
PhylomeDBiQ13003.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13003-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAPWRRLRS LVWEYWAGLL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA
60 70 80 90 100
QVMNAEEHAF RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD
110 120 130 140 150
QLALGVVAIF GPSQGSCTNA VQSICNALEV PHIQLRWKHH PLDNKDTFYV
160 170 180 190 200
NLYPDYASLS HAILDLVQYL KWRSATVVYD DSTGLIRLQE LIMAPSRYNI
210 220 230 240 250
RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ ILKQAMAMGM
260 270 280 290 300
MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWS
310 320 330 340 350
MERLQAAPRS ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC
360 370 380 390 400
HRHKAWRFGG RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED
410 420 430 440 450
GLEKVGVWSP ADGLNITEVA KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR
460 470 480 490 500
KSDRTLYGND RFEGYCIDLL KELAHILGFS YEIRLVEDGK YGAQDDKGQW
510 520 530 540 550
NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV SILYRKPNGT
560 570 580 590 600
NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG
610 620 630 640 650
SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII
660 670 680 690 700
SSYTANLAAF LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK
710 720 730 740 750
ISTFEKMWAF MSSKPSALVK NNEEGIQRAL TADYALLMES TTIEYVTQRN
760 770 780 790 800
CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT IAILQLQEED KLHIMKEKWW
810 820 830 840 850
RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV GEFVYKLRKT
860 870 880 890 900
AEREQRSFCS TVADEIRFSL TCQRRVKHKP QPPMMVKTDA VINMHTFNDR
910
RLPGKDSMAC STSLAPVFP
Length:919
Mass (Da):104,037
Last modified:November 4, 2008 - v3
Checksum:i0F68F6CF33E4CE71
GO
Isoform 2 (identifier: Q13003-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     856-919: RSFCSTVADE...CSTSLAPVFP → VSLRAWSLHRMGNGDSR

Show »
Length:872
Mass (Da):98,727
Checksum:i6479BC2B92321129
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031R → L in AAB30157. (PubMed:16710414)Curated
Sequence conflicti627 – 6271E → V in AAB60407. (PubMed:7719709)Curated
Sequence conflicti713 – 7131S → R in AAB60407. (PubMed:7719709)Curated

RNA editingi

Partially edited.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035695
Natural varianti310 – 3101S → A.2 Publications
Corresponds to variant rs6691840 [ dbSNP | Ensembl ].
VAR_000308
Natural varianti352 – 3521R → Q in RNA edited version.
VAR_000309
Natural varianti391 – 3911D → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_035696

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei856 – 91964RSFCS…APVFP → VSLRAWSLHRMGNGDSR in isoform 2. 1 PublicationVSP_056588Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16127 mRNA. Translation: AAB60407.1.
U16128 Genomic DNA. Translation: AAC50421.1.
AJ249210 mRNA. Translation: CAC80548.1.
AL355386, AC117945 Genomic DNA. Translation: CAI19119.1.
AL591883 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07350.1.
CH471059 Genomic DNA. Translation: EAX07351.1.
S69349 Genomic DNA. Translation: AAB30157.1.
CCDSiCCDS416.1. [Q13003-1]
PIRiI59604.
RefSeqiNP_000822.2. NM_000831.3. [Q13003-1]
UniGeneiHs.128848.

Genome annotation databases

EnsembliENST00000373091; ENSP00000362183; ENSG00000163873. [Q13003-1]
ENST00000373093; ENSP00000362185; ENSG00000163873. [Q13003-2]
GeneIDi2899.
KEGGihsa:2899.
UCSCiuc001caz.2. human. [Q13003-1]

Polymorphism databases

DMDMi212276502.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16127 mRNA. Translation: AAB60407.1 .
U16128 Genomic DNA. Translation: AAC50421.1 .
AJ249210 mRNA. Translation: CAC80548.1 .
AL355386 , AC117945 Genomic DNA. Translation: CAI19119.1 .
AL591883 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07350.1 .
CH471059 Genomic DNA. Translation: EAX07351.1 .
S69349 Genomic DNA. Translation: AAB30157.1 .
CCDSi CCDS416.1. [Q13003-1 ]
PIRi I59604.
RefSeqi NP_000822.2. NM_000831.3. [Q13003-1 ]
UniGenei Hs.128848.

3D structure databases

ProteinModelPortali Q13003.
SMRi Q13003. Positions 34-845.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109156. 4 interactions.
STRINGi 9606.ENSP00000362183.

Chemistry

BindingDBi Q13003.
ChEMBLi CHEMBL3684.
GuidetoPHARMACOLOGYi 452.

PTM databases

PhosphoSitei Q13003.

Polymorphism databases

DMDMi 212276502.

Proteomic databases

PaxDbi Q13003.
PRIDEi Q13003.

Protocols and materials databases

DNASUi 2899.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373091 ; ENSP00000362183 ; ENSG00000163873 . [Q13003-1 ]
ENST00000373093 ; ENSP00000362185 ; ENSG00000163873 . [Q13003-2 ]
GeneIDi 2899.
KEGGi hsa:2899.
UCSCi uc001caz.2. human. [Q13003-1 ]

Organism-specific databases

CTDi 2899.
GeneCardsi GC01M037261.
H-InvDB HIX0028621.
HGNCi HGNC:4581. GRIK3.
HPAi HPA014709.
MIMi 138243. gene.
neXtProti NX_Q13003.
PharmGKBi PA28975.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316680.
GeneTreei ENSGT00760000118920.
HOGENOMi HOG000234371.
HOVERGENi HBG051839.
InParanoidi Q13003.
KOi K05203.
OMAi EEQAFRF.
OrthoDBi EOG71G9W6.
PhylomeDBi Q13003.
TreeFami TF334668.

Enzyme and pathway databases

Reactomei REACT_21254. Presynaptic function of Kainate receptors.
REACT_21346. Activation of Ca-permeable Kainate Receptor.
SignaLinki Q13003.

Miscellaneous databases

ChiTaRSi GRIK3. human.
GeneWikii GRIK3.
GenomeRNAii 2899.
NextBioi 11475.
PROi Q13003.
SOURCEi Search...

Gene expression databases

Bgeei Q13003.
CleanExi HS_GRIK3.
ExpressionAtlasi Q13003. baseline.
Genevestigatori Q13003.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites."
    Nutt S.L., Hoo K.H., Rampersad V., Deverill R.M., Elliott C.E., Fletcher E.J., Adams S.-L., Korczak B., Foldes R.L., Kamboj R.K.
    Recept. Channels 2:315-326(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT ALA-310, RNA EDITING OF POSITION 352.
    Tissue: Fetal brain.
  2. "Myeloid progenitor cell growth and apoptosis involves known and cell-specific ionotropic glutamate receptors."
    Langer A., Xu D., Kuehcke K., Fehse B., Abdallah S., Lother H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Erythroleukemia.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Chromosomal localization of gene for human glutamate receptor subunit-7."
    Puranam R.S., Eubanks J.H., Heinemann S.F., McNamara J.O.
    Somat. Cell Mol. Genet. 19:581-588(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 268-320.
    Tissue: Placenta.
  6. "Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains."
    Schiffer H.H., Swanson G.T., Masliah E., Heinemann S.F.
    J. Neurosci. 20:9025-9033(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ALA-310.
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-215 AND HIS-391.

Entry informationi

Entry nameiGRIK3_HUMAN
AccessioniPrimary (citable) accession number: Q13003
Secondary accession number(s): A9Z1Z8
, B1AMS6, Q13004, Q16136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 4, 2008
Last modified: November 26, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3