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Protein

Glutamate receptor ionotropic, kainate 3

Gene

GRIK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei520GlutamateBy similarity1
Binding sitei525GlutamateBy similarity1
Binding sitei739GlutamateBy similarity1

GO - Molecular functioni

  • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Source: UniProtKB
  • extracellularly glutamate-gated ion channel activity Source: InterPro
  • glutamate receptor activity Source: UniProtKB
  • G-protein coupled receptor binding Source: Reactome
  • ionotropic glutamate receptor activity Source: MGI
  • kainate selective glutamate receptor activity Source: UniProtKB
  • ligand-gated ion channel activity Source: Reactome

GO - Biological processi

  • glutamate receptor signaling pathway Source: UniProtKB
  • G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  • negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
  • regulation of membrane potential Source: MGI

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-500657 Presynaptic function of Kainate receptors
SignaLinkiQ13003

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 3
Short name:
GluK3
Alternative name(s):
Excitatory amino acid receptor 5
Short name:
EAA5
Glutamate receptor 7
Short name:
GluR-7
Short name:
GluR7
Gene namesi
Name:GRIK3
Synonyms:GLUR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163873.9
HGNCiHGNC:4581 GRIK3
MIMi138243 gene
neXtProtiNX_Q13003

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 563ExtracellularSequence analysisAdd BLAST532
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 636CytoplasmicSequence analysisAdd BLAST52
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 820ExtracellularSequence analysisAdd BLAST163
Transmembranei821 – 841HelicalSequence analysisAdd BLAST21
Topological domaini842 – 919CytoplasmicSequence analysisAdd BLAST78

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2899
OpenTargetsiENSG00000163873
PharmGKBiPA28975

Chemistry databases

ChEMBLiCHEMBL3684
DrugBankiDB00142 L-Glutamic Acid
GuidetoPHARMACOLOGYi452

Polymorphism and mutation databases

BioMutaiGRIK3
DMDMi212276502

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001154732 – 919Glutamate receptor ionotropic, kainate 3Add BLAST888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 350By similarity
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei869PhosphoserineBy similarity1
Cross-linki887Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ13003
PeptideAtlasiQ13003
PRIDEiQ13003

PTM databases

iPTMnetiQ13003
PhosphoSitePlusiQ13003

Expressioni

Gene expression databases

BgeeiENSG00000163873
CleanExiHS_GRIK3
GenevisibleiQ13003 HS

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109156, 2 interactors
STRINGi9606.ENSP00000362183

Chemistry databases

BindingDBiQ13003

Structurei

3D structure databases

ProteinModelPortaliQ13003
SMRiQ13003
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni690 – 692Glutamate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054 Eukaryota
ENOG410XPSH LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000234371
HOVERGENiHBG051839
InParanoidiQ13003
KOiK05203
OMAiPHVIRIG
OrthoDBiEOG091G02LN
PhylomeDBiQ13003
TreeFamiTF334668

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAPWRRLRS LVWEYWAGLL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA
60 70 80 90 100
QVMNAEEHAF RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD
110 120 130 140 150
QLALGVVAIF GPSQGSCTNA VQSICNALEV PHIQLRWKHH PLDNKDTFYV
160 170 180 190 200
NLYPDYASLS HAILDLVQYL KWRSATVVYD DSTGLIRLQE LIMAPSRYNI
210 220 230 240 250
RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ ILKQAMAMGM
260 270 280 290 300
MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWS
310 320 330 340 350
MERLQAAPRS ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC
360 370 380 390 400
HRHKAWRFGG RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED
410 420 430 440 450
GLEKVGVWSP ADGLNITEVA KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR
460 470 480 490 500
KSDRTLYGND RFEGYCIDLL KELAHILGFS YEIRLVEDGK YGAQDDKGQW
510 520 530 540 550
NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV SILYRKPNGT
560 570 580 590 600
NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG
610 620 630 640 650
SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII
660 670 680 690 700
SSYTANLAAF LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK
710 720 730 740 750
ISTFEKMWAF MSSKPSALVK NNEEGIQRAL TADYALLMES TTIEYVTQRN
760 770 780 790 800
CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT IAILQLQEED KLHIMKEKWW
810 820 830 840 850
RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV GEFVYKLRKT
860 870 880 890 900
AEREQRSFCS TVADEIRFSL TCQRRVKHKP QPPMMVKTDA VINMHTFNDR
910
RLPGKDSMAC STSLAPVFP
Length:919
Mass (Da):104,037
Last modified:November 4, 2008 - v3
Checksum:i0F68F6CF33E4CE71
GO
Isoform 2 (identifier: Q13003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     856-919: RSFCSTVADE...CSTSLAPVFP → VSLRAWSLHRMGNGDSR

Show »
Length:872
Mass (Da):98,727
Checksum:i6479BC2B92321129
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303R → L in AAB30157 (PubMed:16710414).Curated1
Sequence conflicti627E → V in AAB60407 (PubMed:7719709).Curated1
Sequence conflicti713S → R in AAB60407 (PubMed:7719709).Curated1

RNA editingi

Edited at position 352.1 Publication
Partially edited.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035695215R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs755366301Ensembl.1
Natural variantiVAR_000308310S → A2 PublicationsCorresponds to variant dbSNP:rs6691840Ensembl.1
Natural variantiVAR_000309352R → Q in RNA edited version. 1
Natural variantiVAR_035696391D → H in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056588856 – 919RSFCS…APVFP → VSLRAWSLHRMGNGDSR in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16127 mRNA Translation: AAB60407.1
U16128 Genomic DNA Translation: AAC50421.1
AJ249210 mRNA Translation: CAC80548.1
AC117945 Genomic DNA No translation available.
AL355386 Genomic DNA No translation available.
AL591883 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07350.1
CH471059 Genomic DNA Translation: EAX07351.1
S69349 Genomic DNA Translation: AAB30157.1
CCDSiCCDS416.1 [Q13003-1]
PIRiI59604
RefSeqiNP_000822.2, NM_000831.3 [Q13003-1]
UniGeneiHs.128848

Genome annotation databases

EnsembliENST00000373091; ENSP00000362183; ENSG00000163873 [Q13003-1]
ENST00000373093; ENSP00000362185; ENSG00000163873 [Q13003-2]
GeneIDi2899
KEGGihsa:2899
UCSCiuc001caz.3 human [Q13003-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Similar proteinsi

Entry informationi

Entry nameiGRIK3_HUMAN
AccessioniPrimary (citable) accession number: Q13003
Secondary accession number(s): A9Z1Z8
, B1AMS6, Q13004, Q16136
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 4, 2008
Last modified: May 23, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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