Q13002 (GRIK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate receptor, ionotropic kainate 2

Alternative name(s):
Excitatory amino acid receptor 4
Short name=EAA4
Glutamate receptor 6
Short name=GluR-6
Short name=GluR6

Gene names

Name:	GRIK2
Synonyms:	GLUR6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	908 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 By similarity.
Subunit structure	Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers Probable. Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA By similarity. Interacts with DLG4. Interacts with NETO2 By similarity. Interacts (via C-terminus) with KLHL17 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway By similarity. Ref.8
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.
Tissue specificity	Expression is higher in cerebellum than in cerebral cortex.
Post-translational modification	Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 By similarity. Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome By similarity.
Involvement in disease	Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6) [MIM:611092]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. Ref.10
Miscellaneous	The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7-dinitroquinoxaline-2,3-dione > dihydrokainate.
Sequence similarities	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. [View classification]
RNA editing	Edited at positions 567, 571 and 621. Partially edited. The presence of Gln at position 621 (non-edited) determines channels with low calcium permeability, whereas Arg (edited) determines a higher calcium permeability especially if the preceding sites are fully edited. This receptor is nearly completely edited in all gray matter structures (90% of the receptors), whereas much less edited in the white matter (10% of the receptors). Ref.6 Ref.7

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism RNA editing
Disease	Mental retardation
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ionic channel Ligand-gated ion channel Receptor
PTM	Glycoprotein Isopeptide bond Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glutamate signaling pathway Traceable author statement. Source: ProtInc induction of programmed cell death in response to chemical stimulus Non-traceable author statement. Source: UniProtKB neuron apoptosis Inferred from direct assay. Source: UniProtKB positive regulation of synaptic transmission Inferred from mutant phenotype. Source: UniProtKB regulation of short-term neuronal synaptic plasticity Inferred from mutant phenotype. Source: UniProtKB
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	extracellular-glutamate-gated ion channel activity Inferred from electronic annotation. Source: InterPro kainate selective glutamate receptor activity Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13002-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13002-2)

The sequence of this isoform differs from the canonical sequence as follows:
     855-908: RSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA → ESSIWLVPPYHPDTV

Isoform 3 (identifier: Q13002-3)

The sequence of this isoform differs from the canonical sequence as follows:
     585-908: Missing.

Isoform 4 (identifier: Q13002-4)

The sequence of this isoform differs from the canonical sequence as follows:
     547-622: Missing.

Isoform 5 (identifier: Q13002-5)

The sequence of this isoform differs from the canonical sequence as follows:
     856-908: SFCSAMVEEL...RRLPGKETMA → AKTKLPQDYV...PSSSSLSSCS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 908	877	Glutamate receptor, ionotropic kainate 2		PRO_0000011544
Regions
	Topological domain	32 – 561	530	Extracellular Potential
	Transmembrane	562 – 582	21	Helical; Potential
	Topological domain	583 – 635	53	Cytoplasmic Potential
	Transmembrane	636 – 656	21	Helical; Potential
	Topological domain	657 – 819	163	Extracellular Potential
	Transmembrane	820 – 840	21	Helical; Potential
	Topological domain	841 – 908	68	Cytoplasmic Potential
	Region	516 – 518	3	Glutamate binding By similarity
	Region	689 – 690	2	Glutamate binding By similarity
Sites
	Binding site	523	1	Glutamate By similarity
	Binding site	738	1	Glutamate By similarity
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	275	1	N-linked (GlcNAc...) Potential
	Glycosylation	378	1	N-linked (GlcNAc...) Potential
	Glycosylation	412	1	N-linked (GlcNAc...) Potential
	Glycosylation	423	1	N-linked (GlcNAc...) Potential
	Glycosylation	430	1	N-linked (GlcNAc...) Potential
	Glycosylation	546	1	N-linked (GlcNAc...) Potential
	Cross-link	886		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1) By similarity
Natural variations
	Alternative sequence	547 – 622	76	Missing in isoform 4.		VSP_022334
	Alternative sequence	585 – 908	324	Missing in isoform 3.		VSP_022337
	Alternative sequence	855 – 908	54	RSFCS…KETMA → ESSIWLVPPYHPDTV in isoform 2.		VSP_022335
	Alternative sequence	856 – 908	53	SFCSA…KETMA → AKTKLPQDYVFLPILESVSI STVLSSSPSSSSLSSCS in isoform 5.		VSP_022336
	Natural variant	187	1	E → Q in a breast cancer sample; somatic mutation. Ref.9		VAR_035694
	Natural variant	567	1	I → V in RNA edited version.		VAR_000305
	Natural variant	571	1	Y → C in RNA edited version.		VAR_000306
	Natural variant	621	1	Q → R in RNA edited version.		VAR_000307
	Natural variant	766	1	V → I. Corresponds to variant rs3213608 [ dbSNP | Ensembl ].		VAR_049186
	Natural variant	867	1	M → I. Corresponds to variant rs2235076 [ dbSNP | Ensembl ].		VAR_037633
Experimental info
	Sequence conflict	20	1	L → P in CAC81020. Ref.3
	Sequence conflict	789	1	G → S Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5F34630524401E84	FASTA	908	102,583
	10 20 30 40 50 60 MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 70 80 90 100 110 120 VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 130 140 150 160 170 180 ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 190 200 210 220 230 240 GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 250 260 270 280 290 300 QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 310 320 330 340 350 360 LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 370 380 390 400 410 420 SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 430 440 450 460 470 480 PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 490 500 510 520 530 540 RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 550 560 570 580 590 600 LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARFSPYEWY NPHPCNPDSD 610 620 630 640 650 660 VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 670 680 690 700 710 720 VERMESPIDS ADDLAKQTKI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SRRQSVLVKS 730 740 750 760 770 780 NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 790 800 810 820 830 840 AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 850 860 870 880 890 900 EFLYKSKKNA QLEKRSFCSA MVEELRMSLK CQRRLKHKPQ APVIVKTEEV INMHTFNDRR LPGKETMA
	Isoform 2 [UniParc]. Checksum: D85D8A5CB2B0C1FA	FASTA	869	97,981
	10 20 30 40 50 60 MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 70 80 90 100 110 120 VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 130 140 150 160 170 180 ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 190 200 210 220 230 240 GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 250 260 270 280 290 300 QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 310 320 330 340 350 360 LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 370 380 390 400 410 420 SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 430 440 450 460 470 480 PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 490 500 510 520 530 540 RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 550 560 570 580 590 600 LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARFSPYEWY NPHPCNPDSD 610 620 630 640 650 660 VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 670 680 690 700 710 720 VERMESPIDS ADDLAKQTKI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SRRQSVLVKS 730 740 750 760 770 780 NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 790 800 810 820 830 840 AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 850 860 EFLYKSKKNA QLEKESSIWL VPPYHPDTV
	Isoform 3 [UniParc]. Checksum: E0E9EC92339921A1	FASTA	584	66,108
	10 20 30 40 50 60 MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 70 80 90 100 110 120 VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 130 140 150 160 170 180 ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 190 200 210 220 230 240 GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 250 260 270 280 290 300 QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 310 320 330 340 350 360 LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 370 380 390 400 410 420 SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 430 440 450 460 470 480 PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 490 500 510 520 530 540 RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 550 560 570 580 LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARF
	Isoform 4 [UniParc]. Checksum: C0E9B91AC6AD6012	FASTA	832	93,966
	10 20 30 40 50 60 MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 70 80 90 100 110 120 VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 130 140 150 160 170 180 ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 190 200 210 220 230 240 GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 250 260 270 280 290 300 QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 310 320 330 340 350 360 LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 370 380 390 400 410 420 SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 430 440 450 460 470 480 PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 490 500 510 520 530 540 RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 550 560 570 580 590 600 LYRKPNGSEL MPKALSTRIV GGIWWFFTLI IISSYTANLA AFLTVERMES PIDSADDLAK 610 620 630 640 650 660 QTKIEYGAVE DGATMTFFKK SKISTYDKMW AFMSSRRQSV LVKSNEEGIQ RVLTSDYAFL 670 680 690 700 710 720 MESTTIEFVT QRNCNLTQIG GLIDSKGYGV GTPMGSPYRD KITIAILQLQ EEGKLHMMKE 730 740 750 760 770 780 KWWRGNGCPE EESKEASALG VQNIGGIFIV LAAGLVLSVF VAVGEFLYKS KKNAQLEKRS 790 800 810 820 830 FCSAMVEELR MSLKCQRRLK HKPQAPVIVK TEEVINMHTF NDRRLPGKET MA
	Isoform 5 [UniParc]. Checksum: 50A477CB1265AF26	FASTA	892	100,243
	10 20 30 40 50 60 MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 70 80 90 100 110 120 VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 130 140 150 160 170 180 ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 190 200 210 220 230 240 GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 250 260 270 280 290 300 QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 310 320 330 340 350 360 LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 370 380 390 400 410 420 SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 430 440 450 460 470 480 PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 490 500 510 520 530 540 RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 550 560 570 580 590 600 LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARFSPYEWY NPHPCNPDSD 610 620 630 640 650 660 VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 670 680 690 700 710 720 VERMESPIDS ADDLAKQTKI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SRRQSVLVKS 730 740 750 760 770 780 NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 790 800 810 820 830 840 AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 850 860 870 880 890 EFLYKSKKNA QLEKRAKTKL PQDYVFLPIL ESVSISTVLS SSPSSSSLSS CS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit." Hoo K.H., Nutt S.L., Fletcher E.J., Elliott C.E., Korczak B., Deverill R.M., Rampersad V., Fantaske R.P., Kamboj R.K. Recept. Channels 2:327-337(1994) [PubMed: 7536611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain.
[2]	"Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment." Paschen W., Blackstone C.D., Huganir R.L., Ross C.A. Genomics 20:435-440(1994) [PubMed: 8034316] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Myeloid progenitor cell growth and apoptosis involves know and cell-specific ionotropic glutamate receptor." Langer A., Xu D., Kuehcke K., Fehse B., Abdallah S., Lother H. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[4]	"Genomic organization of the human GRIK2 gene and characterization of multiple splicing variants." Barbon A., Vallini I., Barlati S. Gene 274:187-197(2001) [PubMed: 11675011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), GENE ORGANIZATION.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue." Paschen W., Hedreen J.C., Ross C.A. J. Neurochem. 63:1596-1602(1994) [PubMed: 7523595] [Abstract] Cited for: RNA EDITING OF POSITION 621.
[7]	"RNA editing of human kainate receptor subunits." Nutt S.L., Kamboj R.K. NeuroReport 5:2625-2629(1994) [PubMed: 7696618] [Abstract] Cited for: RNA EDITING OF POSITIONS 567; 571 AND 621. Tissue: Brain.
[8]	"The PDZ1 domain of SAP90. Characterization of structure and binding." Piserchio A., Pellegrini M., Mehta S., Blackman S.M., Garcia E.P., Marshall J., Mierke D.F. J. Biol. Chem. 277:6967-6973(2002) [PubMed: 11744724] [Abstract] Cited for: INTERACTION WITH DLG4.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-187.
[10]	"A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation." Motazacker M.M., Rost B.R., Hucho T., Garshasbi M., Kahrizi K., Ullmann R., Abedini S.S., Nieh S.E., Amini S.H., Goswami C., Tzschach A., Jensen L.R., Schmitz D., Ropers H.H., Najmabadi H., Kuss A.W. Am. J. Hum. Genet. 81:792-798(2007) [PubMed: 17847003] [Abstract] Cited for: INVOLVEMENT IN MRT6.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U16126 mRNA. Translation: AAC50420.1.
AJ252246 mRNA. Translation: CAC81020.1.
AJ301608 mRNA. Translation: CAC67485.1.
AJ301609 mRNA. Translation: CAC67486.1.
AJ301610 mRNA. Translation: CAC67487.1.
AL109919 Genomic DNA. No translation available.
AP002528 Genomic DNA. No translation available.
AP002529 Genomic DNA. No translation available.
AP002530 Genomic DNA. No translation available.

IPI

IPI00011396.
IPI00396613.
IPI00642591.
IPI00746275.
IPI00815931.

PIR

A54260.

RefSeq

NP_001159719.1. NM_001166247.1.
NP_068775.1. NM_021956.4.
NP_786944.1. NM_175768.3.

UniGene

Hs.98262.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3QXM	X-ray	1.65	A/B	429-806	[»]

ProteinModelPortal

Q13002.

SMR

Q13002. Positions 33-415, 423-804.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13002. 2 interactions.

STRING

Q13002.

PTM databases

PhosphoSite

Q13002.

Polymorphism databases

DMDM

2492627.

Proteomic databases

PRIDE

Q13002.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000421544; ENSP00000397026; ENSG00000164418.

GeneID

2898.

KEGG

hsa:2898.

UCSC

uc003pqo.2. human.
uc003pqp.2. human.

Organism-specific databases

CTD

2898.

GeneCards

GC06P101892.

HGNC

HGNC:4580. GRIK2.

HPA

CAB022463.
HPA014395.
HPA014623.

MIM

138244. gene.
611092. phenotype.

neXtProt

NX_Q13002.

Orphanet

88616. Autosomal recessive nonsyndromic intellectual deficit.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG17732.

HOGENOM

HBG381523.

HOVERGEN

HBG051839.

InParanoid

Q13002.

OMA

GVQQFPQ.

OrthoDB

EOG41C6VH.

PhylomeDB

Q13002.

Enzyme and pathway databases

Reactome

REACT_13685. Neuronal System.

Gene expression databases

ArrayExpress

Q13002.

Bgee

Q13002.

CleanEx

HS_GRIK2.

Genevestigator

Q13002.

GermOnline

ENSG00000164418. Homo sapiens.

Family and domain databases

InterPro

IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
[Graphical view]

KO

K05202.

Pfam

PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]

PRINTS

PR00177. NMDARECEPTOR.

SMART

SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

DrugBank

DB00142. L-Glutamic Acid.

NextBio

11469.

SOURCE

Search...

Entry information

Entry name

GRIK2_HUMAN

Accession

Primary (citable) accession number: Q13002
Secondary accession number(s): A6NMY9 , B5MCV0, Q8WWS1, Q96KS6, Q96KS7, Q96KS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.