Q12Z64 (TYPH_METBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Mbur_0255

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides › Methanococcoides burtonii

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	molybdenum ion binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314720

Sequences

	Sequence		Length	Mass (Da)
	Q12Z64 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: A44D08052CF1DFDA	FASTA	506	55,123
	10 20 30 40 50 60 MQLKVQPIDV KVGKYKVILN TIDAKELGVH EGDRVRIKNH VTLTAIVDFT EDMISPGMIG 70 80 90 100 110 120 LYHEVKEALS KEWTETVEVF PAEKPKSTYI IRKTMDGQKL TKEEIDILVK DIVEENLAEI 130 140 150 160 170 180 EIAAFLTATY INDMTDDETE WLTRAMIDSG DKLEFDTHPI MDKHSIGGVP GNKISLLIVP 190 200 210 220 230 240 IVAANGLLIP KTSSRAITGA GGTADLMEIL APVEFDAAEI KRMTEEVGGV LVWGGATNIA 250 260 270 280 290 300 PADDKLIKVE YPLSIDPHCQ MLASIMAKKG AIGADHVVMD IPTGPGTKIK NVQEGRKLAR 310 320 330 340 350 360 DLINLGDRLG MDVDCALTYG ASPVGRTIGP ALEVIEALKV LESFEGPNSL IEKSASLAGM 370 380 390 400 410 420 LLEMGNVAGK DKGYDLAIET LKNGKALTKF KEIIKIQGGN PDVTHKDISV GEFTEDIIAP 430 440 450 460 470 480 NNGYILEMDN KRLVQIARLA GAPNDKGAGI LLHRKQGEPL KEGDPVMTIY AEKKSKLENA 490 500 VKSAKERPPF IVEGMMLERI QSFKEI

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6242.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000300 Genomic DNA. Translation: ABE51262.1.
RefSeq	YP_565012.1. NC_007955.1.
3D structure databases
ProteinModelPortal	Q12Z64.
ModBase	Search...
Protein-protein interaction databases
STRING	259564.Mbur_0255.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE51262; ABE51262; Mbur_0255.
GeneID	3998750.
KEGG	mbu:Mbur_0255.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MBUR259564:GHBZ-318-MONOMER.
Family and domain databases
Gene3D	2.40.40.20. 1 hit. 3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR009010. Asp_de-COase-like_dom. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR006657. MoPterin_dinucl-bd_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF01568. Molydop_binding. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METBU

Accession

Primary (citable) accession number: Q12Z64

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program