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Q12Z64

- AMPPA_METBU

UniProt

Q12Z64 - AMPPA_METBU

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Protein

AMP phosphorylase

Gene

Mbur_0255

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei168 – 1681AMP; via amide nitrogenUniRule annotation
Binding sitei203 – 2031AMP; via amide nitrogenUniRule annotation
Active sitei256 – 2561Proton donorUniRule annotation
Binding sitei264 – 2641AMPUniRule annotation
Binding sitei288 – 2881AMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi194 – 1996AMPUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: UniProtKB-HAMAP
  2. molybdenum ion binding Source: InterPro
  3. oxidoreductase activity Source: InterPro
  4. phosphorylase activity Source: InterPro
  5. thymidine phosphorylase activity Source: InterPro

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
  3. pyrimidine nucleobase metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMBUR259564:GHBZ-266-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Mbur_0255
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
ProteomesiUP000001979: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506AMP phosphorylasePRO_0000314720Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi259564.Mbur_0255.

Structurei

3D structure databases

ProteinModelPortaliQ12Z64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiFINGVRD.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase.
InterProiIPR017713. AMP_phosphorylase.
IPR009010. Asp_de-COase-like_dom.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF50692. SSF50692. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12Z64-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLKVQPIDV KVGKYKVILN TIDAKELGVH EGDRVRIKNH VTLTAIVDFT
60 70 80 90 100
EDMISPGMIG LYHEVKEALS KEWTETVEVF PAEKPKSTYI IRKTMDGQKL
110 120 130 140 150
TKEEIDILVK DIVEENLAEI EIAAFLTATY INDMTDDETE WLTRAMIDSG
160 170 180 190 200
DKLEFDTHPI MDKHSIGGVP GNKISLLIVP IVAANGLLIP KTSSRAITGA
210 220 230 240 250
GGTADLMEIL APVEFDAAEI KRMTEEVGGV LVWGGATNIA PADDKLIKVE
260 270 280 290 300
YPLSIDPHCQ MLASIMAKKG AIGADHVVMD IPTGPGTKIK NVQEGRKLAR
310 320 330 340 350
DLINLGDRLG MDVDCALTYG ASPVGRTIGP ALEVIEALKV LESFEGPNSL
360 370 380 390 400
IEKSASLAGM LLEMGNVAGK DKGYDLAIET LKNGKALTKF KEIIKIQGGN
410 420 430 440 450
PDVTHKDISV GEFTEDIIAP NNGYILEMDN KRLVQIARLA GAPNDKGAGI
460 470 480 490 500
LLHRKQGEPL KEGDPVMTIY AEKKSKLENA VKSAKERPPF IVEGMMLERI

QSFKEI
Length:506
Mass (Da):55,123
Last modified:August 22, 2006 - v1
Checksum:iA44D08052CF1DFDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE51262.1.
RefSeqiWP_011498424.1. NC_007955.1.
YP_565012.1. NC_007955.1.

Genome annotation databases

EnsemblBacteriaiABE51262; ABE51262; Mbur_0255.
GeneIDi3998750.
KEGGimbu:Mbur_0255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE51262.1 .
RefSeqi WP_011498424.1. NC_007955.1.
YP_565012.1. NC_007955.1.

3D structure databases

ProteinModelPortali Q12Z64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259564.Mbur_0255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE51262 ; ABE51262 ; Mbur_0255 .
GeneIDi 3998750.
KEGGi mbu:Mbur_0255.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi FINGVRD.

Enzyme and pathway databases

BioCyci MBUR259564:GHBZ-266-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_02132. AMP_phosphorylase.
InterProi IPR017713. AMP_phosphorylase.
IPR009010. Asp_de-COase-like_dom.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF50692. SSF50692. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-M.

Entry informationi

Entry nameiAMPPA_METBU
AccessioniPrimary (citable) accession number: Q12Z64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3