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Q12Z05 (PNCB_METBU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:Mbur_0321
OrganismMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) [Complete proteome] [HAMAP]
Taxonomic identifier259564 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000146844

Sequences

Sequence LengthMass (Da)Tools
Q12Z05 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 61407D78F9A05DD6

FASTA40546,190
        10         20         30         40         50         60 
MIRSILDNDL YKFTMQMAVL ELFPNARAEY RFINRGAQSF TNDFVNELRR IINKDISKIA 

        70         80         90        100        110        120 
LSEDEYIWLK DNCPFFKPSY IEYLKNFRFN PEEVKIVLTE DNELELCIEG PWHSSILWEI 

       130        140        150        160        170        180 
VLMSTISELY FTVTDNKGEE ISASNANDPE NTLMEEYSSF IGDMGKELDA KGCIFSEFGT 

       190        200        210        220        230        240 
RRRRGFKLHD KVVEVLHELD SFSGTSNVYF AKKYGVRPIG TIGHEWIMGN SALVGLRNAN 

       250        260        270        280        290        300 
KFAFDNWVKV YKGDLSIALS DTFGSKPFFQ NFSIGLAKIY DGVRHDSGDP IKFADEVIEH 

       310        320        330        340        350        360 
YKKLGIDPMK KVLVFSDSLH VSDAVKLKEY CSGRINCSFG IGTTLTNNPD FFSYNPPLNM 

       370        380        390        400 
VIKLHKIDGI PVVKLSDSVE KATGDKDALR VANYIFGRKG LDEQF 

« Hide

References

[1]"Complete sequence of Methanococcoides burtonii DSM 6242."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-M.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000300 Genomic DNA. Translation: ABE51321.1.
RefSeqYP_565071.1. NC_007955.1.

3D structure databases

ProteinModelPortalQ12Z05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING259564.Mbur_0321.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE51321; ABE51321; Mbur_0321.
GeneID3997477.
KEGGmbu:Mbur_0321.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAQAVFHRY.

Enzyme and pathway databases

BioCycMBUR259564:GHBZ-333-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 2 hits.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_METBU
AccessionPrimary (citable) accession number: Q12Z05
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 22, 2006
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways