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Q12Z05

- PNCB_METBU

UniProt

Q12Z05 - PNCB_METBU

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciMBUR259564:GHBZ-333-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:Mbur_0321
    OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
    Taxonomic identifieri259564 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
    ProteomesiUP000001979: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Nicotinate phosphoribosyltransferasePRO_1000146844Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi259564.Mbur_0321.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12Z05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q12Z05-1 [UniParc]FASTAAdd to Basket

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    MIRSILDNDL YKFTMQMAVL ELFPNARAEY RFINRGAQSF TNDFVNELRR    50
    IINKDISKIA LSEDEYIWLK DNCPFFKPSY IEYLKNFRFN PEEVKIVLTE 100
    DNELELCIEG PWHSSILWEI VLMSTISELY FTVTDNKGEE ISASNANDPE 150
    NTLMEEYSSF IGDMGKELDA KGCIFSEFGT RRRRGFKLHD KVVEVLHELD 200
    SFSGTSNVYF AKKYGVRPIG TIGHEWIMGN SALVGLRNAN KFAFDNWVKV 250
    YKGDLSIALS DTFGSKPFFQ NFSIGLAKIY DGVRHDSGDP IKFADEVIEH 300
    YKKLGIDPMK KVLVFSDSLH VSDAVKLKEY CSGRINCSFG IGTTLTNNPD 350
    FFSYNPPLNM VIKLHKIDGI PVVKLSDSVE KATGDKDALR VANYIFGRKG 400
    LDEQF 405
    Length:405
    Mass (Da):46,190
    Last modified:August 22, 2006 - v1
    Checksum:i61407D78F9A05DD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000300 Genomic DNA. Translation: ABE51321.1.
    RefSeqiWP_011498483.1. NC_007955.1.
    YP_565071.1. NC_007955.1.

    Genome annotation databases

    EnsemblBacteriaiABE51321; ABE51321; Mbur_0321.
    GeneIDi3997477.
    KEGGimbu:Mbur_0321.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000300 Genomic DNA. Translation: ABE51321.1 .
    RefSeqi WP_011498483.1. NC_007955.1.
    YP_565071.1. NC_007955.1.

    3D structure databases

    ProteinModelPortali Q12Z05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 259564.Mbur_0321.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE51321 ; ABE51321 ; Mbur_0321 .
    GeneIDi 3997477.
    KEGGi mbu:Mbur_0321.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci MBUR259564:GHBZ-333-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-M.

    Entry informationi

    Entry nameiPNCB_METBU
    AccessioniPrimary (citable) accession number: Q12Z05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3