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Q12YR8

- Q12YR8_METBU

UniProt

Q12YR8 - Q12YR8_METBU

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Protein
DNA gyrase subunit A
Gene
gyrA, Mbur_0420
Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441O-(5'-phospho-DNA)-tyrosine intermediate By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA topological change Source: InterPro
  2. DNA-dependent DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBUR259564:GHBZ-432-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:gyrAUniRule annotation
Ordered Locus Names:Mbur_0420Imported
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)Imported
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
ProteomesiUP000001979: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi259564.Mbur_0420.

Structurei

3D structure databases

ProteinModelPortaliQ12YR8.
SMRiQ12YR8. Positions 52-509.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0188.
HOGENOMiHOG000076278.
KOiK02469.
OMAiQTVFGIN.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_01897. GyrA.
InterProiIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01063. gyrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12YR8-1 [UniParc]FASTAAdd to Basket

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MADNMNNEPG DVQPNDEPLD IKPTDTSERI VPILIQDEMK NSYIDYAMSV    50
IVGRALPDAR DGLKPVHRRI LYAMKEAGMT YDKAYKKSAR VVGDVLGKYH 100
PHGDTAVYDS LVRMVQEFSL RYPLIDGQGN FGSIDGDSAA AMRYTESRMD 150
RISNEMLADI DKETVLYRPN YDGSLKEPTV LPARLPNLLI NGSTGIAVGM 200
ATNMAPHNLG EVIDATLMLI EDPETPISSL MEIVKGPDFP TGGVILGHQG 250
IKSAYETGRG PIKIRAVTSI EEMKNDKKRI VVSELPYQVN KSRLIENIAA 300
LVREKKIVGI SDLRDESDRD GIRVSIELTR NTNPEVILNQ LYKHTQMQTT 350
FGIINLALVD NIPRELTLKE LLQIYLEHRI DVILKRSMFD MRKADEKAHI 400
LKGLMIALDH IDEVIALIRG SNAVDEAKEG LMTRFGLDEV QAKAILDMRL 450
QKLTGLERQK IEDEHGELVK LIEDLKDIIE SDERKYSIIK EELHAIRERF 500
ADKRRTEITG SHVEFEDEDL IPVEEVIVTI TNSGYIKRMP VDTYSQQHRG 550
GKGVIGMETK EQDVVEDIFI SSTHDYLMFF TNRGKVHWKK VYGLPEGSRQ 600
SKGKAVVNLL DLAENESVTA TITVKEFEED KFLFMATRMG TVKKTPLSDF 650
SNVRKAGIIA LKLDEGDELV NVALTDGSKE IMMVSRHGKA IRFCERDVRP 700
MGRTARGVRG MRLTGDDIVV SLDIVDLSTK LLTITENGYG KRTTFDEYRG 750
MKRGGQGVIT IVTSLRNGPV INVKAVKEED EVMVTSSEGI FIRIPVKDIR 800
AQGRNTQGVK IMNVRPGDKV VGVARIKNEE 830
Length:830
Mass (Da):93,076
Last modified:August 22, 2006 - v1
Checksum:iE8B52198D2D7F8F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000300 Genomic DNA. Translation: ABE51408.1.
RefSeqiYP_565158.1. NC_007955.1.

Genome annotation databases

EnsemblBacteriaiABE51408; ABE51408; Mbur_0420.
GeneIDi3996813.
KEGGimbu:Mbur_0420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000300 Genomic DNA. Translation: ABE51408.1 .
RefSeqi YP_565158.1. NC_007955.1.

3D structure databases

ProteinModelPortali Q12YR8.
SMRi Q12YR8. Positions 52-509.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259564.Mbur_0420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE51408 ; ABE51408 ; Mbur_0420 .
GeneIDi 3996813.
KEGGi mbu:Mbur_0420.

Phylogenomic databases

eggNOGi COG0188.
HOGENOMi HOG000076278.
KOi K02469.
OMAi QTVFGIN.

Enzyme and pathway databases

BioCyci MBUR259564:GHBZ-432-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_01897. GyrA.
InterProi IPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01063. gyrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-M.

Entry informationi

Entry nameiQ12YR8_METBU
AccessioniPrimary (citable) accession number: Q12YR8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi