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Q12YR8

- Q12YR8_METBU

UniProt

Q12YR8 - Q12YR8_METBU

Protein

DNA gyrase subunit A

Gene

gyrA

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei144 – 1441O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
    2. DNA topological change Source: InterPro

    Keywords - Molecular functioni

    Isomerase, TopoisomeraseUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMBUR259564:GHBZ-432-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Gene namesi
    Name:gyrAUniRule annotation
    Ordered Locus Names:Mbur_0420Imported
    OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)Imported
    Taxonomic identifieri259564 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
    ProteomesiUP000001979: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

    Protein-protein interaction databases

    STRINGi259564.Mbur_0420.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12YR8.
    SMRiQ12YR8. Positions 52-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0188.
    HOGENOMiHOG000076278.
    KOiK02469.
    OMAiQTVFGIN.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_01897. GyrA.
    InterProiIPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01063. gyrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q12YR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADNMNNEPG DVQPNDEPLD IKPTDTSERI VPILIQDEMK NSYIDYAMSV    50
    IVGRALPDAR DGLKPVHRRI LYAMKEAGMT YDKAYKKSAR VVGDVLGKYH 100
    PHGDTAVYDS LVRMVQEFSL RYPLIDGQGN FGSIDGDSAA AMRYTESRMD 150
    RISNEMLADI DKETVLYRPN YDGSLKEPTV LPARLPNLLI NGSTGIAVGM 200
    ATNMAPHNLG EVIDATLMLI EDPETPISSL MEIVKGPDFP TGGVILGHQG 250
    IKSAYETGRG PIKIRAVTSI EEMKNDKKRI VVSELPYQVN KSRLIENIAA 300
    LVREKKIVGI SDLRDESDRD GIRVSIELTR NTNPEVILNQ LYKHTQMQTT 350
    FGIINLALVD NIPRELTLKE LLQIYLEHRI DVILKRSMFD MRKADEKAHI 400
    LKGLMIALDH IDEVIALIRG SNAVDEAKEG LMTRFGLDEV QAKAILDMRL 450
    QKLTGLERQK IEDEHGELVK LIEDLKDIIE SDERKYSIIK EELHAIRERF 500
    ADKRRTEITG SHVEFEDEDL IPVEEVIVTI TNSGYIKRMP VDTYSQQHRG 550
    GKGVIGMETK EQDVVEDIFI SSTHDYLMFF TNRGKVHWKK VYGLPEGSRQ 600
    SKGKAVVNLL DLAENESVTA TITVKEFEED KFLFMATRMG TVKKTPLSDF 650
    SNVRKAGIIA LKLDEGDELV NVALTDGSKE IMMVSRHGKA IRFCERDVRP 700
    MGRTARGVRG MRLTGDDIVV SLDIVDLSTK LLTITENGYG KRTTFDEYRG 750
    MKRGGQGVIT IVTSLRNGPV INVKAVKEED EVMVTSSEGI FIRIPVKDIR 800
    AQGRNTQGVK IMNVRPGDKV VGVARIKNEE 830
    Length:830
    Mass (Da):93,076
    Last modified:August 22, 2006 - v1
    Checksum:iE8B52198D2D7F8F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000300 Genomic DNA. Translation: ABE51408.1.
    RefSeqiYP_565158.1. NC_007955.1.

    Genome annotation databases

    EnsemblBacteriaiABE51408; ABE51408; Mbur_0420.
    GeneIDi3996813.
    KEGGimbu:Mbur_0420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000300 Genomic DNA. Translation: ABE51408.1 .
    RefSeqi YP_565158.1. NC_007955.1.

    3D structure databases

    ProteinModelPortali Q12YR8.
    SMRi Q12YR8. Positions 52-509.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 259564.Mbur_0420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE51408 ; ABE51408 ; Mbur_0420 .
    GeneIDi 3996813.
    KEGGi mbu:Mbur_0420.

    Phylogenomic databases

    eggNOGi COG0188.
    HOGENOMi HOG000076278.
    KOi K02469.
    OMAi QTVFGIN.

    Enzyme and pathway databases

    BioCyci MBUR259564:GHBZ-432-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_01897. GyrA.
    InterProi IPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01063. gyrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-MImported.

    Entry informationi

    Entry nameiQ12YR8_METBU
    AccessioniPrimary (citable) accession number: Q12YR8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 22, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3