Reviewed, UniProtKB/Swiss-Prot Q12Y52 (MCH_METBU)

Names and origin

Protein names

Recommended name:
    Methenyltetrahydromethanopterin cyclohydrolase
    EC=3.5.4.27
Alternative name(s):
    Methenyl-H4MPT cyclohydrolase

Gene names

Name:	mch
Ordered Locus Names:	Mbur_0653

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of methenyl-H4MPT+ to 5-formyl-H4MPT By similarity.
Catalytic activity	5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin. HAMAP MF_00486
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MCH family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon compound metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methenyltetrahydromethanopterin cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Methenyltetrahydromethanopterin cyclohydrolase HAMAP MF_00486		PRO_1000014397

Sequences

	Sequence		Length	Mass (Da)
	Q12Y52-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 87BC237981F3FA3E	FASTA	320	34,558
	10 20 30 40 50 60 MISVNEKGLA IIDEMLDWEE DVKIESKVLE NGATIIDCGV NVEGGYDAGM YLSRLCLADL 70 80 90 100 110 120 AEISYTKVDL EGLAVPAIQI ATDHPTIACM ASQYAGWRIA VGDYFGMGSG PARGLGLKPK 130 140 150 160 170 180 ELYEEIGYKD EADAAVLVME SDKLPTEEIV EYIAKHCSVE PQNVFIAVAP TSSIAGSVQI 190 200 210 220 230 240 SARVVETGIH KLESIGYDIN KIKSGFGVAP IAPIVGDDTK CMGSTNDCII YCGETYYTVE 250 260 270 280 290 300 DGNAEELEDF VKKAPSSTSR DFGKPFYTTF KEAGFDFFKV DAGMFAPAKI TINDLKSKKS 310 320 FTSGRINPGI LLESFGIKNV

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000300 Genomic DNA. Translation: ABE51624.1.
RefSeq	YP_565374.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3997983.
GenomeReviews	Gene locus Mbur_0653 in contig CP000300_GR.
KEGG	mbu:Mbur_0653.
NMPDR	fig|259564.8.peg.612.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q12Y52.
OMA	Q12Y52. YFAMGSG.
Enzyme and pathway databases
BioCyc	MBUR259564:MBUR_0653-MON.
Family and domain databases
HAMAP	MF_00486. [Tree]
InterPro	IPR003209. METHMP_CycHdrlase. [Graphical view]
Pfam	PF02289. MCH. 1 hit. [Graphical view]
ProDom	PD011637. Cyclohydrolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03120. one_C_mch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCH_METBU

Accession

Primary (citable) accession number: Q12Y52

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)