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Q12Y52 (MCH_METBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methenyltetrahydromethanopterin cyclohydrolase
EC=3.5.4.27
Alternative name(s):
Methenyl-H4MPT cyclohydrolase
Gene names
Name:mch
Ordered Locus Names:Mbur_0653
OrganismMethanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]
Taxonomic identifier259564 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolysis of methenyl-H4MPT+ to 5-formyl-H4MPT By similarity. HAMAP MF_00486

Catalytic activity

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin. HAMAP MF_00486

Subcellular location

Cytoplasm By similarity HAMAP MF_00486.

Sequence similarities

Belongs to the MCH family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmethenyltetrahydromethanopterin cyclohydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Methenyltetrahydromethanopterin cyclohydrolase HAMAP MF_00486
PRO_1000014397

Sequences

Sequence LengthMass (Da)Tools
Q12Y52 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 87BC237981F3FA3E

FASTA32034,558
        10         20         30         40         50         60 
MISVNEKGLA IIDEMLDWEE DVKIESKVLE NGATIIDCGV NVEGGYDAGM YLSRLCLADL 

        70         80         90        100        110        120 
AEISYTKVDL EGLAVPAIQI ATDHPTIACM ASQYAGWRIA VGDYFGMGSG PARGLGLKPK 

       130        140        150        160        170        180 
ELYEEIGYKD EADAAVLVME SDKLPTEEIV EYIAKHCSVE PQNVFIAVAP TSSIAGSVQI 

       190        200        210        220        230        240 
SARVVETGIH KLESIGYDIN KIKSGFGVAP IAPIVGDDTK CMGSTNDCII YCGETYYTVE 

       250        260        270        280        290        300 
DGNAEELEDF VKKAPSSTSR DFGKPFYTTF KEAGFDFFKV DAGMFAPAKI TINDLKSKKS 

       310        320 
FTSGRINPGI LLESFGIKNV

« Hide

References

[1]"Complete sequence of Methanococcoides burtonii DSM 6242."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6242.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000300 Genomic DNA. Translation: ABE51624.1.
RefSeqYP_565374.1. NC_007955.1.

3D structure databases

ProteinModelPortalQ12Y52.
SMRQ12Y52. Positions 1-317.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12Y52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3997983.
GenomeReviewsGene locus Mbur_0653 in contig CP000300_GR.
KEGGmbu:Mbur_0653.
NMPDRfig|259564.8.peg.612.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG05033.
HOGENOMHBG497176.
OMAYFAMGSG.
ProtClustDBPRK02264.

Enzyme and pathway databases

BioCycMBUR259564:MBUR_0653-MONOMER.

Family and domain databases

HAMAPMF_00486. McH.
[Tree]
InterProIPR003209. METHMP_CycHdrlase.
[Graphical view]
KOK01499.
PfamPF02289. MCH. 1 hit.
[Graphical view]
SUPFAMSSF56199. Cyclohydrolase. 1 hit.
TIGRFAMsTIGR03120. One_C_mch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCH_METBU
AccessionPrimary (citable) accession number: Q12Y52
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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