ID   TRM1_METBU              Reviewed;         386 AA.
AC   Q12Y46;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-NOV-2008, entry version 18.
DE   RecName: Full=N(2),N(2)-dimethylguanosine tRNA methyltransferase;
DE            EC=2.1.1.32;
DE   AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase;
DE   AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase;
DE   AltName: Full=tRNA(m(2,2)G26)dimethyltransferase;
GN   Name=trm1; OrderedLocusNames=Mbur_0659;
OS   Methanococcoides burtonii (strain DSM 6242).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K.,
RA   Richardson P.;
RT   "Complete sequence of Methanococcoides burtonii DSM 6242.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Dimethylates a single guanine residue at position 26 of
CC       a number of tRNAs using S-adenosyl-L-methionine as donor of the
CC       methyl groups (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(2)-methylguanine.
CC   -!- SIMILARITY: Belongs to the TRM1 family.
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DR   EMBL; CP000300; ABE51630.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_565380.1; -.
DR   GeneID; 3997989; -.
DR   GenomeReviews; CP000300_GR; Mbur_0659.
DR   KEGG; mbu:Mbur_0659; -.
DR   NMPDR; fig|259564.8.peg.618; -.
DR   HOGENOM; Q12Y46; -.
DR   BioCyc; MBUR259564:MBUR_0659-MON; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_00290; -; 1.
DR   InterPro; IPR002905; TRM_MeTrfase.
DR   PANTHER; PTHR10631; TRM_mtfrase; 1.
DR   Pfam; PF02005; TRM; 1.
DR   TIGRFAMs; TIGR00308; TRM1; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing.
FT   CHAIN         1    386       N(2),N(2)-dimethylguanosine tRNA
FT                                methyltransferase.
FT                                /FTId=PRO_0000259374.
SQ   SEQUENCE   386 AA;  42463 MW;  641E34B4BD46B563 CRC64;
     MLSTKVTEGS TTVSVPVPPE GVPFPPSEAP VFYNPHMELN RDISVAATSA CAKRILLKKD
     MELKDITYLD AMSASGIRGL RIANEVGITS ILNDWSDDAY GLILENIGLT GVSDIAEATC
     KNANVLMHER RFNIVDLDPF GSPTPYLDAA TRSAVHFLEV TATDTAPLCG AHFNSGMRKY
     AAVPLNNEFH SEMGVRILLG KIARELAKHD KGMTPLLSHA TRHYVRTYLQ VKKGAKLADK
     AFKDLGFLSH CEHCGHREIF HGMAISISDH CSSCGNDVYI AGPLWLGQLH EPQYCDEVLL
     ELEDRSLGTK EQAKKLILAC RDELDIPFFY DQHVICKMIG VSAPAMDMFI AALRETGANV
     SRTHFTGISF KTDAKIDTIK DVLRSL
//