ID   ADEC_METBU              Reviewed;         584 AA.
AC   Q12XX8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   05-MAY-2009, entry version 19.
DE   RecName: Full=Adenine deaminase;
DE            Short=Adenase;
DE            Short=Adenine aminase;
DE            EC=3.5.4.2;
GN   Name=ade; OrderedLocusNames=Mbur_0733;
OS   Methanococcoides burtonii (strain DSM 6242).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K.,
RA   Richardson P.;
RT   "Complete sequence of Methanococcoides burtonii DSM 6242.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Adenine + H(2)O = hypoxanthine + NH(3).
CC   -!- COFACTOR: Manganese (By similarity).
CC   -!- SIMILARITY: Belongs to the adenine deaminase family.
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DR   EMBL; CP000300; ABE51698.1; -; Genomic_DNA.
DR   RefSeq; YP_565448.1; -.
DR   GeneID; 3996637; -.
DR   GenomeReviews; CP000300_GR; Mbur_0733.
DR   KEGG; mbu:Mbur_0733; -.
DR   NMPDR; fig|259564.8.peg.691; -.
DR   HOGENOM; Q12XX8; -.
DR   OMA; Q12XX8; IMIREGS.
DR   BioCyc; MBUR259564:MBUR_0733-MON; -.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   HAMAP; MF_01518; -; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR006680; Amidohydro_1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   ProDom; PD001248; Amidohydro_like; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Manganese.
FT   CHAIN         1    584       Adenine deaminase.
FT                                /FTId=PRO_0000292402.
SQ   SEQUENCE   584 AA;  63335 MW;  60E4D2BAA7CD3506 CRC64;
     MNFFMDIRDK VFAATGKVKA DTIFFGGLLI NVNTKEMLYR DIAVKEGYIV GIGDVSSLKG
     DETEMIDVTG KHLCPGLMDG HVHFESSMVT LSQFAVPALA HGTTSVVIDP HEIANVLGRG
     GIELVLDEAA TLPLNAFVAV SSCVPATSFE TAGASIDVDD IVSLIANENV VGLGEMMDYP
     GVVFCDETKL SMIRTALKER LVVDGHCPAL SREQLFGYMC AGISTDHESI EYEEALEKLR
     LGMKLMIREG SAAKALDKFL PRLIGDGVSL ENVFFVTDDK HPSDLLKGYM DVIVRRAIEL
     GLSPLDAISM CTINAAKHYR VDHIVGSLSM GRKADIIVLE DLEKFIIDSV YASGRPVESF
     VPSYEYPDTV FNTVKFDAVT ATDLQIMSDA DKDHRVRVIK VVPDLIVTEN ETFVLHSDRH
     GILMPDVEND VLSVAVIERH GKNGNIGTGF IKGMGLRNGA IGQSIGHDSH NVVVTGVDHS
     DMALCANTIR SMNGGICVVS NGKVVEQLEL PFAGLLSTLP AEEVEKKLTD LHKAVKEIGC
     ALPAPFITHS FIALPVIPSL RLTDMGLFDV DKFSLVSPID EVME
//