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Q12XX8 (ADEC_METBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2
Gene names
Name:ade
Ordered Locus Names:Mbur_0733
OrganismMethanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]
Taxonomic identifier259564 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518

Cofactor

Manganese By similarity. HAMAP MF_01518

Sequence similarities

Belongs to the adenine deaminase family.

Ontologies

Keywords
   LigandManganese
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processadenine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584Adenine deaminase HAMAP MF_01518
PRO_0000292402

Sequences

Sequence LengthMass (Da)Tools
Q12XX8 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 60E4D2BAA7CD3506

FASTA58463,335
        10         20         30         40         50         60 
MNFFMDIRDK VFAATGKVKA DTIFFGGLLI NVNTKEMLYR DIAVKEGYIV GIGDVSSLKG 

        70         80         90        100        110        120 
DETEMIDVTG KHLCPGLMDG HVHFESSMVT LSQFAVPALA HGTTSVVIDP HEIANVLGRG 

       130        140        150        160        170        180 
GIELVLDEAA TLPLNAFVAV SSCVPATSFE TAGASIDVDD IVSLIANENV VGLGEMMDYP 

       190        200        210        220        230        240 
GVVFCDETKL SMIRTALKER LVVDGHCPAL SREQLFGYMC AGISTDHESI EYEEALEKLR 

       250        260        270        280        290        300 
LGMKLMIREG SAAKALDKFL PRLIGDGVSL ENVFFVTDDK HPSDLLKGYM DVIVRRAIEL 

       310        320        330        340        350        360 
GLSPLDAISM CTINAAKHYR VDHIVGSLSM GRKADIIVLE DLEKFIIDSV YASGRPVESF 

       370        380        390        400        410        420 
VPSYEYPDTV FNTVKFDAVT ATDLQIMSDA DKDHRVRVIK VVPDLIVTEN ETFVLHSDRH 

       430        440        450        460        470        480 
GILMPDVEND VLSVAVIERH GKNGNIGTGF IKGMGLRNGA IGQSIGHDSH NVVVTGVDHS 

       490        500        510        520        530        540 
DMALCANTIR SMNGGICVVS NGKVVEQLEL PFAGLLSTLP AEEVEKKLTD LHKAVKEIGC 

       550        560        570        580 
ALPAPFITHS FIALPVIPSL RLTDMGLFDV DKFSLVSPID EVME

« Hide

References

[1]"Complete sequence of Methanococcoides burtonii DSM 6242."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6242.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000300 Genomic DNA. Translation: ABE51698.1.
RefSeqYP_565448.1. NC_007955.1.

3D structure databases

ProteinModelPortalQ12XX8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12XX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3996637.
GenomeReviewsGene locus Mbur_0733 in contig CP000300_GR.
KEGGmbu:Mbur_0733.
NMPDRfig|259564.8.peg.691.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG05049.
HOGENOMHBG725357.
OMAVGLGEMM.
PhylomeDBQ12XX8.

Enzyme and pathway databases

BioCycMBUR259564:MBUR_0733-MONOMER.

Family and domain databases

HAMAPMF_01518. Adenine_deamin.
[Tree]
InterProIPR006679. Adenine_deam.
IPR006680. Amidohydro_1.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01486.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR01178. Ade. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADEC_METBU
AccessionPrimary (citable) accession number: Q12XX8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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