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Q12XH1

- DUT_METBU

UniProt

Q12XH1 - DUT_METBU

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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciMBUR259564:GHBZ-927-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:Mbur_0910
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
ProteomesiUP000001979: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000061431Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi259564.Mbur_0910.

Structurei

3D structure databases

ProteinModelPortaliQ12XH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228599.
KOiK01520.
OMAiWDAGYEG.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12XH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLLSQNELR ELVLANPPLV ENMIDMDTQL QPNGVEMTLK EIRTIKSPGA
60 70 80 90 100
VDFDNSGRRL SEGDTIEFNE DGWIHLDPGV YKVLLNEIVN IPKDLAAIAK
110 120 130 140 150
PRSTLIRCGA TLETAVWDAG YSGRSECMIV VHNKDGFDLK KDARIMQLLF
160 170
YHLHTEVEEG YSGSYQNENI
Length:170
Mass (Da):19,122
Last modified:August 22, 2006 - v1
Checksum:i77861D19B36ECE59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000300 Genomic DNA. Translation: ABE51855.1.
RefSeqiWP_011499008.1. NC_007955.1.
YP_565605.1. NC_007955.1.

Genome annotation databases

EnsemblBacteriaiABE51855; ABE51855; Mbur_0910.
GeneIDi3998654.
KEGGimbu:Mbur_0910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000300 Genomic DNA. Translation: ABE51855.1 .
RefSeqi WP_011499008.1. NC_007955.1.
YP_565605.1. NC_007955.1.

3D structure databases

ProteinModelPortali Q12XH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259564.Mbur_0910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE51855 ; ABE51855 ; Mbur_0910 .
GeneIDi 3998654.
KEGGi mbu:Mbur_0910.

Phylogenomic databases

eggNOGi COG0717.
HOGENOMi HOG000228599.
KOi K01520.
OMAi WDAGYEG.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci MBUR259564:GHBZ-927-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00635. dUTPase_arch.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-M.

Entry informationi

Entry nameiDUT_METBU
AccessioniPrimary (citable) accession number: Q12XH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3