Q12XF4 (Q12XF4_METBU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
F420-dependent methylenetetrahydromethanopterin dehydrogenase HAMAP MF_00058
Short name=MTD HAMAP MF_00058
EC=1.5.99.9 HAMAP MF_00058

Alternative name(s):
Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase HAMAP MF_00058

Gene names

Name:	mtd HAMAP MF_00058 EMBL ABE51872.1
Ordered Locus Names:	Mbur_0929

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible reduction of methenyl-H4MPT+ to methylene-H4MPT By similarity. HAMAP MF_00058
Catalytic activity	5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420. HAMAP MF_00058
Pathway	One-carbon metabolism; methanogenesis from CO(2); 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1. HAMAP MF_00058
Sequence similarities	Belongs to the MTD family. HAMAP MF_00058

Ontologies

Keywords
Biological process	Methanogenesis HAMAP MF_00058 One-carbon metabolism HAMAP MF_00058
Molecular function	Oxidoreductase HAMAP MF_00058 EMBL ABE51872.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: HAMAP one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro methylenetetrahydromethanopterin dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q12XF4 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: F05A912DFF1E4F64	FASTA	273	29,760
	10 20 30 40 50 60 MAKIGFIKLG NLGMSQVIDL VQDEIAAREG ISVRVFGTGP KMGKDEAAET AALKEWDADF 70 80 90 100 110 120 YVMISPNSSA PGPTAAREIY KDVPCIVISD GPTKKDDRQA LEDAGFGYII MTVDPLIGAK 130 140 150 160 170 180 REFLDSVEMA SFNSDAMKVL STCGVVRLIQ EELDIVTAQV DEGKEIVLPH ILAKPEKCIE 190 200 210 220 230 240 RAGFSNPYAK AKALAALHMA DKVAQINFPA CFMMKEIEQV TLTTATAHEM MRAAAQLAID 250 260 270 AREIEKSNDT VLRQPHAKKG NILSKTALYE KQQ

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6242.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000300 Genomic DNA. Translation: ABE51872.1.
RefSeq	YP_565622.1. NC_007955.1.
3D structure databases
ProteinModelPortal	Q12XF4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12XF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3996543.
GenomeReviews	Gene locus Mbur_0929 in contig CP000300_GR.
KEGG	mbu:Mbur_0929.
NMPDR	fig|259564.8.peg.883.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04866.
HOGENOM	HBG538567.
OMA	NPYAKAK.
ProtClustDB	PRK00994.
Family and domain databases
HAMAP	MF_00058. MTD. [Tree]
InterPro	IPR002844. Methylene_DH. [Graphical view]
KO	K00319.
Pfam	PF01993. MTD. 1 hit. [Graphical view]
PIRSF	PIRSF005627. MTD. 1 hit.
ProDom	PD017604. Methylene_DH. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF102324. MeTD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q12XF4_METBU

Accession

Primary (citable) accession number: Q12XF4

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)