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Q12X18 (AROA_METBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase

EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:Mbur_1078
OrganismMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) [Complete proteome] [HAMAP]
Taxonomic identifier259564 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP-Rule MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP-Rule MF_00210

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00210

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP-Rule MF_00210
PRO_1000012450

Sequences

Sequence LengthMass (Da)Tools
Q12X18 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: D27049A1FF358E31

FASTA42745,424
        10         20         30         40         50         60 
MKVTVGRSGV HGEIFAPASK SYTHRAITVA ALSKESIIHR PLISADTQST IKACEMLGAY 

        70         80         90        100        110        120 
IEKDGDKLLI SGVDGEPQTP DNVIDVGNSG TTLRFMTAIA ALGQGTTVLT GDNSIRSRPN 

       130        140        150        160        170        180 
GPLLQVLNDL GVQSISTRGD GCAPIVVTGG LKGAIAKIDG SISSQFISAL LLACPLTKNS 

       190        200        210        220        230        240 
TTLSIKGELK SRPYVDVTLD ILEKAGAEIY LEDNQNLKFI IPGNQKYRLK EYTVPGDFSS 

       250        260        270        280        290        300 
ASYLLAAAAM TDTKIKVNNL YPSMQGDAAI IDILKEMGAN IYWNKEEGTV EVNGGKLHGI 

       310        320        330        340        350        360 
TMDAGATPDL VPTVAVLGAV AEGETVITNA EHVRYKETDR LHAMAVELDK MGISTSEEKD 

       370        380        390        400        410        420 
KLTIKGGELK GADVHGWHDH RIVMSLTLAG MIAGDTTIDT AEAIFISYPN FFDSMRSIGA 


DVILSEQ 

« Hide

References

[1]"Complete sequence of Methanococcoides burtonii DSM 6242."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-M.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000300 Genomic DNA. Translation: ABE52008.1.
RefSeqYP_565758.1. NC_007955.1.

3D structure databases

ProteinModelPortalQ12X18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING259564.Mbur_1078.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE52008; ABE52008; Mbur_1078.
GeneID3998015.
KEGGmbu:Mbur_1078.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0128.
HOGENOMHOG000247372.
KOK00800.
OMASYDDHRM.

Enzyme and pathway databases

BioCycMBUR259564:GHBZ-1099-MONOMER.
UniPathwayUPA00053; UER00089.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00210. EPSP_synth.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01356. aroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_METBU
AccessionPrimary (citable) accession number: Q12X18
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways