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Q12X18

- AROA_METBU

UniProt

Q12X18 - AROA_METBU

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Protein

3-phosphoshikimate 1-carboxyvinyltransferase

Gene

aroA

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251Shikimate-3-phosphateUniRule annotation
Binding sitei118 – 1181PhosphoenolpyruvateUniRule annotation
Binding sitei191 – 1911Shikimate-3-phosphateUniRule annotation
Active sitei309 – 3091Proton acceptorUniRule annotation
Binding sitei336 – 3361Shikimate-3-phosphateUniRule annotation
Active sitei337 – 3371Proton donorUniRule annotation
Binding sitei340 – 3401PhosphoenolpyruvateUniRule annotation
Binding sitei381 – 3811PhosphoenolpyruvateUniRule annotation

GO - Molecular functioni

  1. 3-phosphoshikimate 1-carboxyvinyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciMBUR259564:GHBZ-1099-MONOMER.
UniPathwayiUPA00053.

Names & Taxonomyi

Protein namesi
Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.19UniRule annotation)
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthaseUniRule annotation
Short name:
EPSP synthaseUniRule annotation
Short name:
EPSPSUniRule annotation
Gene namesi
Name:aroAUniRule annotation
Ordered Locus Names:Mbur_1078
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
ProteomesiUP000001979: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4274273-phosphoshikimate 1-carboxyvinyltransferasePRO_1000012450Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi259564.Mbur_1078.

Structurei

3D structure databases

ProteinModelPortaliQ12X18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 212Shikimate-3-phosphate bindingUniRule annotation
Regioni88 – 914PhosphoenolpyruvateUniRule annotation
Regioni163 – 1653Shikimate-3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the EPSP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0128.
HOGENOMiHOG000247372.
KOiK00800.
OMAiSYDDHRM.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00210. EPSP_synth.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000505. EPSPS. 1 hit.
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01356. aroA. 1 hit.
PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12X18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVTVGRSGV HGEIFAPASK SYTHRAITVA ALSKESIIHR PLISADTQST
60 70 80 90 100
IKACEMLGAY IEKDGDKLLI SGVDGEPQTP DNVIDVGNSG TTLRFMTAIA
110 120 130 140 150
ALGQGTTVLT GDNSIRSRPN GPLLQVLNDL GVQSISTRGD GCAPIVVTGG
160 170 180 190 200
LKGAIAKIDG SISSQFISAL LLACPLTKNS TTLSIKGELK SRPYVDVTLD
210 220 230 240 250
ILEKAGAEIY LEDNQNLKFI IPGNQKYRLK EYTVPGDFSS ASYLLAAAAM
260 270 280 290 300
TDTKIKVNNL YPSMQGDAAI IDILKEMGAN IYWNKEEGTV EVNGGKLHGI
310 320 330 340 350
TMDAGATPDL VPTVAVLGAV AEGETVITNA EHVRYKETDR LHAMAVELDK
360 370 380 390 400
MGISTSEEKD KLTIKGGELK GADVHGWHDH RIVMSLTLAG MIAGDTTIDT
410 420
AEAIFISYPN FFDSMRSIGA DVILSEQ
Length:427
Mass (Da):45,424
Last modified:August 22, 2006 - v1
Checksum:iD27049A1FF358E31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE52008.1.
RefSeqiYP_565758.1. NC_007955.1.

Genome annotation databases

EnsemblBacteriaiABE52008; ABE52008; Mbur_1078.
GeneIDi3998015.
KEGGimbu:Mbur_1078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE52008.1 .
RefSeqi YP_565758.1. NC_007955.1.

3D structure databases

ProteinModelPortali Q12X18.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 259564.Mbur_1078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE52008 ; ABE52008 ; Mbur_1078 .
GeneIDi 3998015.
KEGGi mbu:Mbur_1078.

Phylogenomic databases

eggNOGi COG0128.
HOGENOMi HOG000247372.
KOi K00800.
OMAi SYDDHRM.

Enzyme and pathway databases

UniPathwayi UPA00053 .
BioCyci MBUR259564:GHBZ-1099-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00210. EPSP_synth.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view ]
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000505. EPSPS. 1 hit.
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01356. aroA. 1 hit.
PROSITEi PS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-M.

Entry informationi

Entry nameiAROA_METBU
AccessioniPrimary (citable) accession number: Q12X18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3