ID   DNLI_METBU              Reviewed;         567 AA.
AC   Q12X08;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=DNA ligase;
DE            EC=6.5.1.1;
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP];
GN   Name=lig; OrderedLocusNames=Mbur_1088;
OS   Methanococcoides burtonii (strain DSM 6242).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K.,
RA   Richardson P.;
RT   "Complete sequence of Methanococcoides burtonii DSM 6242.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA
CC       during DNA replication, DNA recombination and DNA repair (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
CC       (deoxyribonucleotide)(m) = AMP + diphosphate +
CC       (deoxyribonucleotide)(n+m).
CC   -!- COFACTOR: Divalent metal cations (By similarity).
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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DR   EMBL; CP000300; ABE52018.1; -; Genomic_DNA.
DR   RefSeq; YP_565768.1; -.
DR   GeneID; 3998025; -.
DR   GenomeReviews; CP000300_GR; Mbur_1088.
DR   KEGG; mbu:Mbur_1088; -.
DR   NMPDR; fig|259564.8.peg.1034; -.
DR   HOGENOM; Q12X08; -.
DR   OMA; Q12X08; SNLHLGA.
DR   BioCyc; MBUR259564:MBUR_1088-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:HAMAP.
DR   GO; GO:0006281; P:DNA repair; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:HAMAP.
DR   HAMAP; MF_00407; -; 1.
DR   InterPro; IPR000977; DNA_ligase.
DR   InterPro; IPR012309; DNA_ligase_A_C.
DR   InterPro; IPR012310; DNA_ligase_A_M.
DR   InterPro; IPR012308; DNA_ligase_A_N.
DR   InterPro; IPR016059; DNA_ligase_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; FALSE_NEG.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage;
KW   DNA recombination; DNA repair; DNA replication; Ligase; Metal-binding;
KW   Nucleotide-binding.
FT   CHAIN         1    567       DNA ligase.
FT                                /FTId=PRO_1000049869.
FT   ACT_SITE    262    262       N6-AMP-lysine intermediate (By
FT                                similarity).
FT   BINDING     260    260       ATP (By similarity).
FT   BINDING     267    267       ATP (By similarity).
FT   BINDING     282    282       ATP (By similarity).
FT   BINDING     312    312       ATP (By similarity).
FT   BINDING     352    352       ATP (By similarity).
FT   BINDING     427    427       ATP (By similarity).
FT   BINDING     433    433       ATP (By similarity).
SQ   SEQUENCE   567 AA;  62743 MW;  3942FDE27D6C32F0 CRC64;
     MTDFKEFADV CKQIEHISSS LEMTDVVSDM LKSISTEELP VVTHFVMGDV FPAWSVEQLG
     VGTSLLYSAL SESSGLSLKE IEDLVRSTGD IGETAVAALG KKKKNKKKNQ ASLSFFSEDA
     ASVSISIMDV FERFLDISRY SGAGSQSSKM RNLQFLFNSS SSEEARYLAR LTIEDLRIGV
     GEGIVRDAIS KAFDVPAGDI ERGFMLTNDL GLVAVAAKEG GIEEISKLRM ELDRPIKMML
     AQVTPSIEAA IKDLGMLAVE WKFDGARVQI HKKGDSINIF SRRLENVTLS LPDIVEAVKL
     HVKADSAILE GEAVAVDENG APRAFQDILK RFRRKYDVET MVREIPLTLN LFDILYLNGD
     VLMDQSLLRR REQLVACVEN CDSIKVDEQV LTDDVNVVND IYAAALNGGH EGVMLKNPEA
     SYSPGKRGKN WLKKKPIMET LDLVVIAAEW GYGKRANLIG SYALACFDPE DGKFLPIGKV
     ATGFSDEQLA ELTEVFSELI IGESGREIEL KPDVVFEIAF EEIQKSTNYG SGYALRFPRL
     VNVREDKSPE EAETIDRIES IYLSQRG
//