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Protein

DNA ligase

Gene

lig

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei260ATPUniRule annotation1
Active sitei262N6-AMP-lysine intermediateUniRule annotation1
Binding sitei267ATPUniRule annotation1
Binding sitei282ATPUniRule annotation1
Binding sitei312ATPUniRule annotation1
Binding sitei352ATPUniRule annotation1
Binding sitei427ATPUniRule annotation1
Binding sitei433ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBUR259564:G1G6A-1137-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mbur_1088
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
Proteomesi
  • UP000001979 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000498691 – 567DNA ligaseAdd BLAST567

Interactioni

Protein-protein interaction databases

STRINGi259564.Mbur_1088

Structurei

3D structure databases

ProteinModelPortaliQ12X08
SMRiQ12X08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q12X08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDFKEFADV CKQIEHISSS LEMTDVVSDM LKSISTEELP VVTHFVMGDV
60 70 80 90 100
FPAWSVEQLG VGTSLLYSAL SESSGLSLKE IEDLVRSTGD IGETAVAALG
110 120 130 140 150
KKKKNKKKNQ ASLSFFSEDA ASVSISIMDV FERFLDISRY SGAGSQSSKM
160 170 180 190 200
RNLQFLFNSS SSEEARYLAR LTIEDLRIGV GEGIVRDAIS KAFDVPAGDI
210 220 230 240 250
ERGFMLTNDL GLVAVAAKEG GIEEISKLRM ELDRPIKMML AQVTPSIEAA
260 270 280 290 300
IKDLGMLAVE WKFDGARVQI HKKGDSINIF SRRLENVTLS LPDIVEAVKL
310 320 330 340 350
HVKADSAILE GEAVAVDENG APRAFQDILK RFRRKYDVET MVREIPLTLN
360 370 380 390 400
LFDILYLNGD VLMDQSLLRR REQLVACVEN CDSIKVDEQV LTDDVNVVND
410 420 430 440 450
IYAAALNGGH EGVMLKNPEA SYSPGKRGKN WLKKKPIMET LDLVVIAAEW
460 470 480 490 500
GYGKRANLIG SYALACFDPE DGKFLPIGKV ATGFSDEQLA ELTEVFSELI
510 520 530 540 550
IGESGREIEL KPDVVFEIAF EEIQKSTNYG SGYALRFPRL VNVREDKSPE
560
EAETIDRIES IYLSQRG
Length:567
Mass (Da):62,743
Last modified:August 22, 2006 - v1
Checksum:i3942FDE27D6C32F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA Translation: ABE52018.1
RefSeqiWP_011499166.1, NC_007955.1

Genome annotation databases

EnsemblBacteriaiABE52018; ABE52018; Mbur_1088
GeneIDi3998025
KEGGimbu:Mbur_1088

Similar proteinsi

Entry informationi

Entry nameiDNLI_METBU
AccessioniPrimary (citable) accession number: Q12X08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health