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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mbur_1305
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
Proteomesi
  • UP000001979 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987421 – 2152-phospho-L-lactate guanylyltransferaseAdd BLAST215

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi259564.Mbur_1305.

Structurei

3D structure databases

SMRiQ12WF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472. Archaea.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OrthoDBiPOG093Z0CT7.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiView protein in InterPro
IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR40392. PTHR40392. 1 hit.
PfamiView protein in Pfam
PF01983. CofC. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12WF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVIPYKNE NAKSRLSPIL SKKDREEFVE LMLKDVIKAL DDAEVVNIDI
60 70 80 90 100
LTTSAEGIPN DFNGNVTITE PGLNDSINEY LQNANEPILI IMADLPLVTG
110 120 130 140 150
DHIRKIISFS EDVVIVPGKG GGTNILFIRH PNEFTVKYHD CSFISHCEIT
160 170 180 190 200
DELDKSMHIF DSFLASTDID EPHDIVELML HGKGQAKEYA EKRFGSETGK
210
GRVKISHLSK LSGFV
Length:215
Mass (Da):23,967
Last modified:October 5, 2010 - v2
Checksum:iCD5BBE41BABEFEED
GO

Sequence cautioni

The sequence ABE52223 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE52223.1. Different initiation.
RefSeqiWP_048063292.1. NC_007955.1.

Genome annotation databases

EnsemblBacteriaiABE52223; ABE52223; Mbur_1305.
GeneIDi3998593.
KEGGimbu:Mbur_1305.

Entry informationi

Entry nameiCOFC_METBU
AccessioniPrimary (citable) accession number: Q12WF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: December 20, 2017
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families