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Protein

2-phospho-L-lactate transferase

Gene

cofD

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP.UniRule annotation

Catalytic activityi

(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = guanosine 5'-phosphate + coenzyme F420-0.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate transferaseUniRule annotation (EC:2.7.8.28UniRule annotation)
Alternative name(s):
LPPG:FO 2-phospho-L-lactate transferaseUniRule annotation
Gene namesi
Name:cofDUniRule annotation
Ordered Locus Names:Mbur_1411
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
Proteomesi
  • UP000001979 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002594781 – 3062-phospho-L-lactate transferaseAdd BLAST306

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi259564.Mbur_1411.

Structurei

3D structure databases

ProteinModelPortaliQ12W53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04395. Archaea.
COG0391. LUCA.
HOGENOMiHOG000230060.
KOiK11212.
OMAiHFQEYWV.

Family and domain databases

CDDicd07186. CofD_like. 1 hit.
HAMAPiMF_01257. CofD. 1 hit.
InterProiIPR002882. CofD/UPF0052.
IPR010115. P-lactate_Trfase.
[Graphical view]
PfamiPF01933. UPF0052. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01819. F420_cofD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12W53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIFSGGTGT PKLLDGLRHI VPEDELTVVV NTAEDVWVSG NLITPDIDTI
60 70 80 90 100
LYLLSGRIDR DKWWGVKDDT FQTHREMKEL GHDESMMIGD LDRVTHIMRS
110 120 130 140 150
DLLRQGLSLS ESIHELLSVY GIGVNVLPMS DDSVRTIVET PSGHVHFQDF
160 170 180 190 200
WVKQHGVPEV LSVEQEGIEE ASICSLVLEA LESDDEVLIG PSNPITSIGP
210 220 230 240 250
IISLPGMSRI LRKKKVVAVS PIIGNEAVSG PAGKFMTARG FDVSSRGIAD
260 270 280 290 300
CYREFLDVLV LDDRDTTSPE QFQKMGVDVV STNTLMKSLE ISKDLSKKIV

SIFANI
Length:306
Mass (Da):33,699
Last modified:August 22, 2006 - v1
Checksum:i6C953AA08785E509
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE52323.1.
RefSeqiWP_011499468.1. NC_007955.1.

Genome annotation databases

EnsemblBacteriaiABE52323; ABE52323; Mbur_1411.
GeneIDi3998512.
KEGGimbu:Mbur_1411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE52323.1.
RefSeqiWP_011499468.1. NC_007955.1.

3D structure databases

ProteinModelPortaliQ12W53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi259564.Mbur_1411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE52323; ABE52323; Mbur_1411.
GeneIDi3998512.
KEGGimbu:Mbur_1411.

Phylogenomic databases

eggNOGiarCOG04395. Archaea.
COG0391. LUCA.
HOGENOMiHOG000230060.
KOiK11212.
OMAiHFQEYWV.

Enzyme and pathway databases

UniPathwayiUPA00071.

Family and domain databases

CDDicd07186. CofD_like. 1 hit.
HAMAPiMF_01257. CofD. 1 hit.
InterProiIPR002882. CofD/UPF0052.
IPR010115. P-lactate_Trfase.
[Graphical view]
PfamiPF01933. UPF0052. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01819. F420_cofD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOFD_METBU
AccessioniPrimary (citable) accession number: Q12W53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 22, 2006
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.