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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathway: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine/guanine phosphoribosyltransferase (hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMBUR259564:GHBZ-1462-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Mbur_1435
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
ProteomesiUP000001979 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415471Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi259564.Mbur_1435.

Structurei

3D structure databases

ProteinModelPortaliQ12W31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000228520.
KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12W31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEVLQESLR KAPIVIRGEY PYFIHPISDG IPSLEPELLD EIADHMIDIA
60 70 80 90 100
GKDYDRIVSI EAMGIPLATV LSMKTGKPMS IVRKRQYGLE GEVILSQSTG
110 120 130 140 150
YSKGELYING ISKGETVLVV DDVISTGGTL KALLPALENM GANICNVIVV
160 170 180 190
ISRGDGAAKM SDMGYNVNTL VKIDVDMDGV SILEVAGEQQ
Length:190
Mass (Da):20,481
Last modified:August 22, 2006 - v1
Checksum:i712E235B95470A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE52345.1.
RefSeqiWP_011499490.1. NC_007955.1.
YP_566095.1. NC_007955.1.

Genome annotation databases

EnsemblBacteriaiABE52345; ABE52345; Mbur_1435.
GeneIDi3998463.
KEGGimbu:Mbur_1435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA. Translation: ABE52345.1.
RefSeqiWP_011499490.1. NC_007955.1.
YP_566095.1. NC_007955.1.

3D structure databases

ProteinModelPortaliQ12W31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi259564.Mbur_1435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE52345; ABE52345; Mbur_1435.
GeneIDi3998463.
KEGGimbu:Mbur_1435.

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000228520.
KOiK00759.
OMAiIATDIPY.

Enzyme and pathway databases

UniPathwayiUPA00591; UER00648.
BioCyciMBUR259564:GHBZ-1462-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6242 / NBRC 107633 / OCM 468 / ACE-M.

Entry informationi

Entry nameiHPRT_METBU
AccessioniPrimary (citable) accession number: Q12W31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: August 22, 2006
Last modified: May 27, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.