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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine/guanine phosphoribosyltransferase (hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

BioCyciMBUR259564:G1G6A-1501-MONOMER
UniPathwayiUPA00591; UER00648

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Mbur_1435
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
Proteomesi
  • UP000001979 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004154711 – 190Hypoxanthine/guanine phosphoribosyltransferaseAdd BLAST190

Proteomic databases

PRIDEiQ12W31

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi259564.Mbur_1435

Structurei

3D structure databases

ProteinModelPortaliQ12W31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00030 Archaea
COG0503 LUCA
HOGENOMiHOG000228520
KOiK00759
OMAiFIHPISD
OrthoDBiPOG093Z0AYC

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01467 Hypx_phosphoribosyltr, 1 hit
InterProiView protein in InterPro
IPR026597 HGPRTase-like
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

Q12W31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEVLQESLR KAPIVIRGEY PYFIHPISDG IPSLEPELLD EIADHMIDIA
60 70 80 90 100
GKDYDRIVSI EAMGIPLATV LSMKTGKPMS IVRKRQYGLE GEVILSQSTG
110 120 130 140 150
YSKGELYING ISKGETVLVV DDVISTGGTL KALLPALENM GANICNVIVV
160 170 180 190
ISRGDGAAKM SDMGYNVNTL VKIDVDMDGV SILEVAGEQQ
Length:190
Mass (Da):20,481
Last modified:August 22, 2006 - v1
Checksum:i712E235B95470A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA Translation: ABE52345.1
RefSeqiWP_011499490.1, NC_007955.1

Genome annotation databases

EnsemblBacteriaiABE52345; ABE52345; Mbur_1435
GeneIDi3998463
KEGGimbu:Mbur_1435

Similar proteinsi

Entry informationi

Entry nameiHPRT_METBU
AccessioniPrimary (citable) accession number: Q12W31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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