Q12W02 (UVRC_METBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UvrABC system protein C
Short name=Protein UvrC

Alternative name(s):
Excinuclease ABC subunit C

Gene names

Name:	uvrC
Ordered Locus Names:	Mbur_1467

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides › Methanococcoides burtonii

Protein attributes

Sequence length	604 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203
Subunit structure	Interacts with UvrB in an incision complex By similarity.
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00203.
Sequence similarities	Belongs to the UvrC family. Contains 1 GIY-YIG domain. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 604	604	UvrABC system protein C HAMAP-Rule MF_00203		PRO_0000264983
Regions
	Domain	10 – 89	80	GIY-YIG
	Domain	199 – 234	36	UVR

Sequences

	Sequence		Length	Mass (Da)
	Q12W02 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: E1053C329FA5776F	FASTA	604	68,213
	10 20 30 40 50 60 MRPDISNIPE LPGVYLMKDI SDNIIYIGKA KSLKKRVSQY FQSSKNHSSK TRAMVRKIAD 70 80 90 100 110 120 VDYIVTESEV AALILEANLV KKNRPHYNID LKDDKRYPYV KVTVNTKFPK IFITRRRLMD 130 140 150 160 170 180 GALYFGPYTN VKPVRQTLDM ISQIFRIKRC NRRVDGKGKR ACLNYHIDRC YAPCNGSITP 190 200 210 220 230 240 EEYRNNVMEA VKLFKGETSG TIKELQEKMN IHAIAQEYES AAVIRDQIDA LKSLSRQQTA 250 260 270 280 290 300 TAGNDDSDII ATASDDETVF VQIFYIRDGN MVGKADMSLS WGDATGNIAR VTEEFIKQYY 310 320 330 340 350 360 QDAPVPPEIL VQYPIPEKEL VIKWLSEKAA RSVQIQVPQR GNKKRLMEMA EQNAQMTLEQ 370 380 390 400 410 420 SHLKQSDKEQ ALQALLQLRD ALALSTLPAH IEGFDISNIS GTDAVGSMVV FENGLPANSK 430 440 450 460 470 480 YRHFNIKTVK GIDDFAMMAE VVKRRYTHQK AEKDKLPDLI LIDGGPGQVS AAMGSLKELQ 490 500 510 520 530 540 LDIPLVGLAK RFEHIIVPKD GTDEVVILPH TSEALKVLMR VRDESHRFAV SSHRRRRTAR 550 560 570 580 590 600 LSHSELDTIP GIGASRKKAL LNHFSSIEQI RHASVEELTA VEGISKGLAE RIVAHFNKER VENQ

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6242.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000300 Genomic DNA. Translation: ABE52374.1.
RefSeq	YP_566124.1. NC_007955.1.
3D structure databases
ProteinModelPortal	Q12W02.
ModBase	Search...
Protein-protein interaction databases
STRING	259564.Mbur_1467.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE52374; ABE52374; Mbur_1467.
GeneID	3998496.
KEGG	mbu:Mbur_1467.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0322.
HOGENOM	HOG000279960.
KO	K03703.
OMA	QKLFPIR.
ProtClustDB	CLSK2776820.
Enzyme and pathway databases
BioCyc	MBUR259564:GHBZ-1495-MONOMER.
Family and domain databases
Gene3D	3.40.1440.10. 1 hit. 4.10.860.10. 1 hit.
HAMAP	MF_00203. UvrC.
InterPro	IPR027299. GIY-YIG_dom. IPR000305. GIY-YIG_SF. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR010994. RuvA_2-like. IPR001943. UVR_dom. IPR004791. UvrC. IPR001162. UvrC_homol_region. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF02151. UVR. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
SMART	SM00465. GIYc. 1 hit. SM00278. HhH1. 2 hits. [Graphical view]
SUPFAM	SSF47781. RuvA_2_like. 1 hit. SSF46600. UvrB_C. 1 hit. SSF82771. UvrC_N. 1 hit.
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50164. GIY_YIG. 1 hit. PS50151. UVR. 1 hit. PS50165. UVRC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRC_METBU

Accession

Primary (citable) accession number: Q12W02

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	August 22, 2006
Last modified:	May 29, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program