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Q12VU4 (MTRE_METBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tetrahydromethanopterin S-methyltransferase subunit E
EC=2.1.1.86
Alternative name(s):
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E
Gene names
Name:mtrE
Ordered Locus Names:Mbur_1525
OrganismMethanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]
Taxonomic identifier259564 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides ›

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step By similarity. HAMAP-Rule MF_01098

Catalytic activity

5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. HAMAP-Rule MF_01098

Subunit structure

The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_01098.

Sequence similarities

Belongs to the MtrE family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Tetrahydromethanopterin S-methyltransferase subunit E HAMAP-Rule MF_01098
PRO_1000064943

Regions

Transmembrane85 – 10521Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane258 – 27821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q12VU4 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: E88BD4537D22C5C5

FASTA30131,934
        10         20         30         40         50         60 
MEPLMGMGVL ALMGAAATIA GTTEDLESDV GSQSNPNSQV QLAPQMMYPH RIYNKAISGE 

        70         80         90        100        110        120 
PPSNALICAI GGTVASVLMT ANLSVIFAIA IGALVASAVH GTYCITAYMG RTASQKRFRQ 

       130        140        150        160        170        180 
PIYLDILRSH TPVMMGYAFI TTFCILVVSY IMVAVLAHPF PLTLLAFIWG ITVGAIGSST 

       190        200        210        220        230        240 
GDVHYGAERE FQNVEFGSGL NAANSGNIVR KAESGLRNGI DNSWFCAKFG GPVTGLAFGM 

       250        260        270        280        290        300 
TVFLSGWVTA VFNPAISLTM GWLSVAAGVI LVLLLIIWNR KIEVAARKAF GPYKEEEEVA 


A

« Hide

References

[1]"Complete sequence of Methanococcoides burtonii DSM 6242."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6242.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000300 Genomic DNA. Translation: ABE52432.1.
RefSeqYP_566182.1. NC_007955.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING259564.Mbur_1525.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE52432; ABE52432; Mbur_1525.
GeneID3997348.
KEGGmbu:Mbur_1525.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4059.
HOGENOMHOG000229708.
KOK00581.
OMASNPNSQV.
ProtClustDBPRK00972.

Enzyme and pathway databases

BioCycMBUR259564:GHBZ-1583-MONOMER.

Family and domain databases

HAMAPMF_01098. MtrE.
InterProIPR005780. MeTrfase_E.
[Graphical view]
PfamPF04206. MtrE. 1 hit.
[Graphical view]
PIRSFPIRSF016509. MtrE. 1 hit.
TIGRFAMsTIGR01113. mtrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTRE_METBU
AccessionPrimary (citable) accession number: Q12VU4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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