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Reviewed, UniProtKB/Swiss-Prot Q12VU4 (MTRE_METBU)

Last modified June 16, 2009. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tetrahydromethanopterin S-methyltransferase subunit E
    EC=2.1.1.86
Alternative name(s):
    N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E
Gene names
Name: mtrE
Ordered Locus Names: Mbur_1525
OrganismMethanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]
Taxonomic identifier259564 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step By similarity.

Catalytic activity

5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. HAMAP MF_01098

Subunit structure

The complex is composed of 8 subunits; mtrA, mtrB, mtrC, mtrD, mtrE, mtrF, mtrG and mtrH By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the mtrE family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Tetrahydromethanopterin S-methyltransferase subunit E HAMAP MF_01098
PRO_1000064943

Regions

Transmembrane85 – 10521 Potential
Transmembrane130 – 15021 Potential
Transmembrane151 – 17121 Potential
Transmembrane232 – 25221 Potential
Transmembrane258 – 27821 Potential

Sequences

Sequence LengthMass (Da)Tools
Q12VU4-1 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: E88BD4537D22C5C5

FASTA30131,934
        10         20         30         40         50         60 
MEPLMGMGVL ALMGAAATIA GTTEDLESDV GSQSNPNSQV QLAPQMMYPH RIYNKAISGE 

        70         80         90        100        110        120 
PPSNALICAI GGTVASVLMT ANLSVIFAIA IGALVASAVH GTYCITAYMG RTASQKRFRQ 

       130        140        150        160        170        180 
PIYLDILRSH TPVMMGYAFI TTFCILVVSY IMVAVLAHPF PLTLLAFIWG ITVGAIGSST 

       190        200        210        220        230        240 
GDVHYGAERE FQNVEFGSGL NAANSGNIVR KAESGLRNGI DNSWFCAKFG GPVTGLAFGM 

       250        260        270        280        290        300 
TVFLSGWVTA VFNPAISLTM GWLSVAAGVI LVLLLIIWNR KIEVAARKAF GPYKEEEEVA 


A 

« Hide

References

[1]"Complete sequence of Methanococcoides burtonii DSM 6242."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000300 Genomic DNA. Translation: ABE52432.1.
RefSeqYP_566182.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3997348.
GenomeReviewsGene locus Mbur_1525 in contig CP000300_GR.
KEGGmbu:Mbur_1525.
NMPDRfig|259564.8.peg.1452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ12VU4.
OMAQ12VU4. SNPNSQV.

Enzyme and pathway databases

BioCycMBUR259564:MBUR_1525-MON.

Family and domain databases

HAMAPMF_01098.
[Tree]
InterProIPR005780. MeTrfase_E.
[Graphical view]
PfamPF04206. MtrE. 1 hit.
[Graphical view]
PIRSFPIRSF016509. MtrE. 1 hit.
TIGRFAMsTIGR01113. mtrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTRE_METBU
AccessionPrimary (citable) accession number: Q12VU4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents