Reviewed, UniProtKB/Swiss-Prot Q12UX3 (PDAD_METBU)

Names and origin

Protein names

Recommended name:
    Pyruvoyl-dependent arginine decarboxylase
      Short name=PvlArgDC
    EC=4.1.1.19
Cleaved into the following 2 chains:
    1- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit beta
    2- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	pdaD
Ordered Locus Names:	Mbur_1870

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity.
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 40	40	Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity		PRO_1000068393
	Chain	41 – 180	140	Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity		PRO_1000068394
Sites
	Site	40 – 41	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	41	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12UX3-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: AD44697D865CD971	FASTA	180	19,688
	10 20 30 40 50 60 MIPKKAFVVK GTGVHKDKLA SFELALRDAG IEKFNLVTVS SILPPNCSIV SRKEGLEELA 70 80 90 100 110 120 PGQIVYCVMA KNQTNEPERM IAAAIGNAVP VDSNDYGYIS EHHSFGEDER TAGIYAEDLA 130 140 150 160 170 180 ATMLATTLGI EFDADSAWGE RERVYKASGH IFDTVHYCRC VKGDENGLWT TVVVSMVFVL

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000300 Genomic DNA. Translation: ABE52753.1.
RefSeq	YP_566503.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3997531.
GenomeReviews	Gene locus Mbur_1870 in contig CP000300_GR.
KEGG	mbu:Mbur_1870.
NMPDR	fig|259564.8.peg.1777.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q12UX3.
OMA	Q12UX3. YKMSGKI.
Enzyme and pathway databases
BioCyc	MBUR259564:MBUR_1870-MON.
Family and domain databases
HAMAP	MF_01404. [Tree]
InterPro	IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. DUF44. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00286. PvlArgDC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD_METBU

Accession

Primary (citable) accession number: Q12UX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 22, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)