ID   AROD_METBU              Reviewed;         233 AA.
AC   Q12UJ8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=3-dehydroquinate dehydratase;
DE            Short=3-dehydroquinase;
DE            EC=4.2.1.10;
DE   AltName: Full=Type I DHQase;
GN   Name=aroD; OrderedLocusNames=Mbur_1999;
OS   Methanococcoides burtonii (strain DSM 6242).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K.,
RA   Richardson P.;
RT   "Complete sequence of Methanococcoides burtonii DSM 6242.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 3/7.
CC   -!- SIMILARITY: Belongs to the type-I 3-dehydroquinase family.
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DR   EMBL; CP000300; ABE52878.1; -; Genomic_DNA.
DR   RefSeq; YP_566628.1; -.
DR   GeneID; 3996951; -.
DR   GenomeReviews; CP000300_GR; Mbur_1999.
DR   KEGG; mbu:Mbur_1999; -.
DR   NMPDR; fig|259564.8.peg.1910; -.
DR   HOGENOM; Q12UJ8; -.
DR   OMA; Q12UJ8; IAKLAVM.
DR   BioCyc; MBUR259564:MBUR_1999-MON; -.
DR   GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   HAMAP; MF_00214; -; 1.
DR   InterPro; IPR018508; 3-dehydroquinate_DH_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001381; DHquinase_I.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF01487; DHquinase_I; 1.
DR   ProDom; PD005337; DHquinase_I; 1.
DR   TIGRFAMs; TIGR01093; aroD; 1.
DR   PROSITE; PS01028; DEHYDROQUINASE_I; FALSE_NEG.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Schiff base.
FT   CHAIN         1    233       3-dehydroquinate dehydratase.
FT                                /FTId=PRO_1000043172.
FT   ACT_SITE    132    132       Proton acceptor (By similarity).
FT   ACT_SITE    159    159       Schiff-base intermediate with substrate
FT                                (By similarity).
SQ   SEQUENCE   233 AA;  25711 MW;  6A9ACC5FF57A2DF0 CRC64;
     MLKIGTFDLE ERPAIVAAIS NEPLQQCKTA AEHGADILEI RFDLLGITTS KEAANLLRML
     KGTTSLPCIA TNRLQSQGGN WEGTEENRIA LLEDIMHLTD AVDIELETDE QLRDRIVKKA
     KEESKTTIIS SHDFERTPDK ETLKSILDHS HDAGADIAKL AVMPENMQDV LNLLEVTLEV
     DDVCTISMGK LGKHTRIIAP LYGSKLTYAS VSDAVAPGQL KVEDLKKAME MME
//