Q12UJ8 (AROD_METBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	Mbur_1999

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000043172
Sites
	Active site	132	1	Proton acceptor By similarity
	Active site	159	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12UJ8 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 6A9ACC5FF57A2DF0	FASTA	233	25,711
	10 20 30 40 50 60 MLKIGTFDLE ERPAIVAAIS NEPLQQCKTA AEHGADILEI RFDLLGITTS KEAANLLRML 70 80 90 100 110 120 KGTTSLPCIA TNRLQSQGGN WEGTEENRIA LLEDIMHLTD AVDIELETDE QLRDRIVKKA 130 140 150 160 170 180 KEESKTTIIS SHDFERTPDK ETLKSILDHS HDAGADIAKL AVMPENMQDV LNLLEVTLEV 190 200 210 220 230 DDVCTISMGK LGKHTRIIAP LYGSKLTYAS VSDAVAPGQL KVEDLKKAME MME

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6242.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000300 Genomic DNA. Translation: ABE52878.1.
RefSeq	YP_566628.1. NC_007955.1.
3D structure databases
ProteinModelPortal	Q12UJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12UJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3996951.
GenomeReviews	Gene locus Mbur_1999 in contig CP000300_GR.
KEGG	mbu:Mbur_1999.
NMPDR	fig|259564.8.peg.1910.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12575.
HOGENOM	HBG732926.
OMA	VARRTVI.
PhylomeDB	Q12UJ8.
ProtClustDB	CLSK450616.
Enzyme and pathway databases
BioCyc	MBUR259564:MBUR_1999-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_METBU

Accession

Primary (citable) accession number: Q12UJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program