Q12UE9 (Q12UE9_METBU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
EC=6.3.5.3 HAMAP MF_00420

Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP MF_00420

Gene names

Name:	purL HAMAP MF_00420 EMBL ABE52927.1
Ordered Locus Names:	Mbur_2051

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length	715 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420
Subunit structure	Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP MF_00420
Subcellular location	Cytoplasm By similarity HAMAP MF_00420.
Sequence similarities	Belongs to the FGAMS family. HAMAP MF_00420

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00420
Cellular component	Cytoplasm HAMAP MF_00420
Ligand	ATP-binding HAMAP MF_00420 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00420 EMBL ABE52927.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q12UE9 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 0F7EC04149C1BB83	FASTA	715	76,390
	10 20 30 40 50 60 MLPENDLKII TEEMGREPNL VEQGCFLNLW SEHCSYRSSA PLLKTFTTVG DRVIIGPGDD 70 80 90 100 110 120 AAIIRFGEGW VLAIGMESHN HPSYVDPYNG SATGVGGIVR DIISMGARPI ALMDPLYFGP 130 140 150 160 170 180 LNTPKNLYLF EHIIEGIAGY GNCIGVPVVR GETYFDESYS GNPLVNVVCV GLAREENIVT 190 200 210 220 230 240 ACAQKAGNKL VLIGSTTGRD GLGGASFASR DLSEEAEAED RPSIQIGDPF TEKLAIEATL 250 260 270 280 290 300 EAIGAGYVLS CRDLGAAGLA GASSEMASKG KLGMRLEADK VILREDGMTP YEIMIAESQE 310 320 330 340 350 360 RILMEVEPEN VDAVLAIGKK YDLHASMIGE LTERLYYTVE FEGEMVADIP VMLLTEGAPT 370 380 390 400 410 420 FERPSTAPPE REIGEKPDLP ADMKKVVLDI LSSHNIASKE WIYRQYDHEV QVRTVEKPGS 430 440 450 460 470 480 DAAVLRIGDG KGLAMSCGCN PRHTLLDPYE GGKGTLIENS MNLAVKGAEG IALVDCLNFG 490 500 510 520 530 540 NPERPDIYWQ FKQAILGLGD AARSLSIPVV GGNVSLYNES GEYGTAIAPT PSIGLIGITG 550 560 570 580 590 600 ELETVPQSHF AGEGNTIILV GNTLDEMGGS EYYNMVGLRL NGNVPKVTDE SVKVVETLIN 610 620 630 640 650 660 VVRDGNVVAA HDVSAGGLAV ALSEMCDSIG AEIDLTSVGD NLRADDVLFS ESHARAILVT 670 680 690 700 710 SSPEKVKEML ADVPHTVIGT VGGNNLSIKG NGFDLSLSLE EISDARASLT KMMME

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6242.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000300 Genomic DNA. Translation: ABE52927.1.
RefSeq	YP_566677.1. NC_007955.1.
3D structure databases
ProteinModelPortal	Q12UE9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12UE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3997433.
GenomeReviews	Gene locus Mbur_2051 in contig CP000300_GR.
KEGG	mbu:Mbur_2051.
NMPDR	fig|259564.8.peg.1961.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04101.
HOGENOM	HBG311214.
OMA	YGNSFGV.
ProtClustDB	PRK01213.
Family and domain databases
HAMAP	MF_00420. PurL_2. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR010074. PRibForGlyAmidine_synth_II. IPR016188. PurM_N-like. [Graphical view]
KO	K01952.
Pfam	PF00586. AIRS. 2 hits. PF02769. AIRS_C. 2 hits. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 2 hits. SSF55326. PurM_N-like. 2 hits.
TIGRFAMs	TIGR01736. FGAM_synth_II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q12UE9_METBU

Accession

Primary (citable) accession number: Q12UE9

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)