Q12U23 (SURE_METBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Mbur_2188

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	5'-nucleotidase surE HAMAP MF_00060		PRO_0000335292
Sites
	Metal binding	10	1	Divalent metal cation By similarity
	Metal binding	11	1	Divalent metal cation By similarity
	Metal binding	41	1	Divalent metal cation By similarity
	Metal binding	96	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12U23 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 3EDDC6B0626B6FE2	FASTA	261	28,309
	10 20 30 40 50 60 MSKRILLTND DGVYAAGIRA AYRSVSDLGD VTVSAPAQQQ SGVGRSISIF EPLRITRTTI 70 80 90 100 110 120 DGIEVHAIGG TPTDSVILGI FTIMKELPDL ILSGFNIGEN ISTDTITTSG TIGAALEGAS 130 140 150 160 170 180 YGVPAIAASL QVTEEGLKFD DLRDFQHDFD VGIKFVNGVA KKVLKNGLPE NVDLLNINIP 190 200 210 220 230 240 HFVEEDSEVE ITRLARKFFR TGVEERRDPR GRPYYWIAGD LIHTAEKGTD VNAIEKGHIS 250 260 VTPISLDATS PINFSEIEHL M

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6242.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000300 Genomic DNA. Translation: ABE53053.1.
RefSeq	YP_566803.1. NC_007955.1.
3D structure databases
ProteinModelPortal	Q12U23.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12U23.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3997044.
GenomeReviews	Gene locus Mbur_2188 in contig CP000300_GR.
KEGG	mbu:Mbur_2188.
NMPDR	fig|259564.8.peg.2092.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05083.
HOGENOM	HBG600532.
OMA	NINIPEN.
PhylomeDB	Q12U23.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	MBUR259564:MBUR_2188-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_METBU

Accession

Primary (citable) accession number: Q12U23

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program