ID   IDI2_METBU              Reviewed;         362 AA.
AC   Q12TH8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Isopentenyl-diphosphate delta-isomerase;
DE            Short=IPP isomerase;
DE            EC=5.3.3.2;
DE   AltName: Full=Isopentenyl pyrophosphate isomerase;
GN   Name=fni; OrderedLocusNames=Mbur_2397;
OS   Methanococcoides burtonii (strain DSM 6242).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K.,
RA   Richardson P.;
RT   "Complete sequence of Methanococcoides burtonii DSM 6242.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the 1,3-allylic rearrangement of the
CC       homoallylic substrate isopentenyl (IPP) to its allylic isomer,
CC       dimethylallyl diphosphate (DMAPP) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Isopentenyl diphosphate = dimethylallyl
CC       diphosphate.
CC   -!- COFACTOR: FMN (By similarity).
CC   -!- COFACTOR: NADPH (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the IPP isomerase type 2 family.
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DR   EMBL; CP000300; ABE53248.1; -; Genomic_DNA.
DR   RefSeq; YP_566998.1; -.
DR   GeneID; 3998985; -.
DR   GenomeReviews; CP000300_GR; Mbur_2397.
DR   KEGG; mbu:Mbur_2397; -.
DR   NMPDR; fig|259564.8.peg.2301; -.
DR   HOGENOM; Q12TH8; -.
DR   OMA; Q12TH8; AMGVGSQ.
DR   BioCyc; MBUR259564:MBUR_2397-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0004452; F:isopentenyl-diphosphate delta-isomerase act...; IEA:HAMAP.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00354; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000262; FMN-dep_DH.
DR   InterPro; IPR011179; IPdP_isomerase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR10578:SF3; IPdP_isomerase; 1.
DR   Pfam; PF01070; FMN_dh; 1.
DR   PIRSF; PIRSF003314; IPP_isomerase; 1.
DR   TIGRFAMs; TIGR02151; IPP_isom_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Flavoprotein; FMN; Isomerase;
KW   Isoprene biosynthesis; NADP.
FT   CHAIN         1    362       Isopentenyl-diphosphate delta-isomerase.
FT                                /FTId=PRO_1000048447.
SQ   SEQUENCE   362 AA;  38308 MW;  C0036E26AEE63CB5 CRC64;
     MSTSKRKIEH LELCAKRPVE SRNVTSGFDD VMLIHKALPQ IHMDEIDLST DFLGKSLKAP
     FLIASITGGH PDTTPVNAAL AEAAEELGVG IGVGSQRAAI EDPEQESSFS VVRDKAPNAF
     VYGNVGAAQI KEYGIEAIEK LVDMLDADAL AVHLNFLQEA IQPEGDRDAT GVLEMIKEVC
     SLNVPIIAKE TGAGISKEDA ALLKEAGVSA IDVGGVGGTS WSGVEVYRAH DSGDAISEDL
     GNLYWDFGIP TVSSVLECRS FVPVVATGGV RTGLDIAKSL SLGAYAASAA LPFVGPALIG
     ADEVVSSLSK MLNELRVAMF LCGCGNINEL RTSSKVTVTG WTKEYITQRG FDPKDLDIRS
     DL
//