Reviewed, UniProtKB/Swiss-Prot Q12TH8 (IDI2_METBU)

Names and origin

Protein names

Recommended name:
    Isopentenyl-diphosphate delta-isomerase
      Short name=IPP isomerase
    EC=5.3.3.2
Alternative name(s):
    Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	Mbur_2397

Organism

Methanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]

Taxonomic identifier

259564 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity.
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354
Cofactor	FMN By similarity. NADPH By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354		PRO_1000048447

Sequences

	Sequence		Length	Mass (Da)
	Q12TH8-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: C0036E26AEE63CB5	FASTA	362	38,308
	10 20 30 40 50 60 MSTSKRKIEH LELCAKRPVE SRNVTSGFDD VMLIHKALPQ IHMDEIDLST DFLGKSLKAP 70 80 90 100 110 120 FLIASITGGH PDTTPVNAAL AEAAEELGVG IGVGSQRAAI EDPEQESSFS VVRDKAPNAF 130 140 150 160 170 180 VYGNVGAAQI KEYGIEAIEK LVDMLDADAL AVHLNFLQEA IQPEGDRDAT GVLEMIKEVC 190 200 210 220 230 240 SLNVPIIAKE TGAGISKEDA ALLKEAGVSA IDVGGVGGTS WSGVEVYRAH DSGDAISEDL 250 260 270 280 290 300 GNLYWDFGIP TVSSVLECRS FVPVVATGGV RTGLDIAKSL SLGAYAASAA LPFVGPALIG 310 320 330 340 350 360 ADEVVSSLSK MLNELRVAMF LCGCGNINEL RTSSKVTVTG WTKEYITQRG FDPKDLDIRS DL

References

[1]

"Complete sequence of Methanococcoides burtonii DSM 6242." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000300 Genomic DNA. Translation: ABE53248.1.
RefSeq	YP_566998.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3998985.
GenomeReviews	Gene locus Mbur_2397 in contig CP000300_GR.
KEGG	mbu:Mbur_2397.
NMPDR	fig|259564.8.peg.2301.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q12TH8.
OMA	Q12TH8. AMGVGSQ.
Enzyme and pathway databases
BioCyc	MBUR259564:MBUR_2397-MON.
Family and domain databases
HAMAP	MF_00354. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10578:SF3. IPdP_isomerase. 1 hit.
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_METBU

Accession

Primary (citable) accession number: Q12TH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)