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Q12TH8 (IDI2_METBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isopentenyl-diphosphate delta-isomerase
Short name=IPP isomerase
EC=5.3.3.2
Alternative name(s):
Isopentenyl pyrophosphate isomerase
Gene names
Name:fni
Ordered Locus Names:Mbur_2397
OrganismMethanococcoides burtonii (strain DSM 6242) [Complete proteome] [HAMAP]
Taxonomic identifier259564 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanococcoides

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00354

Catalytic activity

Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354

Cofactor

FMN By similarity. HAMAP MF_00354

NADPH By similarity. HAMAP MF_00354

Subcellular location

Cytoplasm By similarity HAMAP MF_00354.

Sequence similarities

Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Cellular componentCytoplasm
   LigandFMN
Flavoprotein
NADP
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

isopentenyl-diphosphate delta-isomerase activity

Inferred from electronic annotation. Source: EC

oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354
PRO_1000048447

Sequences

Sequence LengthMass (Da)Tools
Q12TH8 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: C0036E26AEE63CB5

FASTA36238,308
        10         20         30         40         50         60 
MSTSKRKIEH LELCAKRPVE SRNVTSGFDD VMLIHKALPQ IHMDEIDLST DFLGKSLKAP 

        70         80         90        100        110        120 
FLIASITGGH PDTTPVNAAL AEAAEELGVG IGVGSQRAAI EDPEQESSFS VVRDKAPNAF 

       130        140        150        160        170        180 
VYGNVGAAQI KEYGIEAIEK LVDMLDADAL AVHLNFLQEA IQPEGDRDAT GVLEMIKEVC 

       190        200        210        220        230        240 
SLNVPIIAKE TGAGISKEDA ALLKEAGVSA IDVGGVGGTS WSGVEVYRAH DSGDAISEDL 

       250        260        270        280        290        300 
GNLYWDFGIP TVSSVLECRS FVPVVATGGV RTGLDIAKSL SLGAYAASAA LPFVGPALIG 

       310        320        330        340        350        360 
ADEVVSSLSK MLNELRVAMF LCGCGNINEL RTSSKVTVTG WTKEYITQRG FDPKDLDIRS 


DL

« Hide

References

[1]"Complete sequence of Methanococcoides burtonii DSM 6242."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6242.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000300 Genomic DNA. Translation: ABE53248.1.
RefSeqYP_566998.1. NC_007955.1.

3D structure databases

ProteinModelPortalQ12TH8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12TH8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3998985.
GenomeReviewsGene locus Mbur_2397 in contig CP000300_GR.
KEGGmbu:Mbur_2397.
NMPDRfig|259564.8.peg.2301.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04310.
HOGENOMHBG354479.
OMAGSQRAAI.
ProtClustDBPRK05437.

Enzyme and pathway databases

BioCycMBUR259564:MBUR_2397-MONOMER.

Family and domain databases

HAMAPMF_00354. Idi_2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR011179. IPdP_isomerase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01823.
PANTHERPTHR10578:SF3. IPdP_isomerase. 1 hit.
PfamPF01070. FMN_dh. 2 hits.
[Graphical view]
PIRSFPIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMsTIGR02151. IPP_isom_2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIDI2_METBU
AccessionPrimary (citable) accession number: Q12TH8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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