ID   DP2L_METBU              Reviewed;        1145 AA.
AC   Q12TF2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   22-JUL-2008, entry version 16.
DE   RecName: Full=DNA polymerase II large subunit;
DE            Short=Pol II;
DE            EC=2.7.7.7;
GN   Name=polC; OrderedLocusNames=Mbur_2423;
OS   Methanococcoides burtonii (strain DSM 6242).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K.,
RA   Richardson P.;
RT   "Complete sequence of Methanococcoides burtonii DSM 6242.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possesses two activities: a DNA synthesis (polymerase)
CC       and an exonucleolytic activity that degrades single stranded DNA
CC       in the 3'- to 5'-direction. Has a template-primer preference which
CC       is characteristic of a replicative DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts
CC       progressively in a 3'- to 5'-direction, releasing nucleoside 5'-
CC       phosphates.
CC   -!- SUBUNIT: Heterodimer of a large subunit and a small subunit (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the archaeal DNA polymerase II family.
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DR   EMBL; CP000300; ABE53274.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_567024.1; -.
DR   GeneID; 3999013; -.
DR   GenomeReviews; CP000300_GR; Mbur_2423.
DR   KEGG; mbu:Mbur_2423; -.
DR   NMPDR; fig|259564.8.peg.2327; -.
DR   HOGENOM; Q12TF2; -.
DR   BioCyc; MBUR259564:MBUR_2423-MON; -.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:HAMAP.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0000738; P:DNA catabolic process, exonucleolytic; IEA:HAMAP.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IEA:HAMAP.
DR   HAMAP; MF_00324; -; 1.
DR   InterPro; IPR004475; PolC_DP2.
DR   InterPro; IPR016033; PolC_DP2_N.
DR   Pfam; PF03833; PolC_DP2; 1.
DR   PIRSF; PIRSF016275; PolC_DP2; 1.
DR   TIGRFAMs; TIGR00354; polC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA replication; DNA-binding;
KW   DNA-directed DNA polymerase; Exonuclease; Hydrolase;
KW   Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1145       DNA polymerase II large subunit.
FT                                /FTId=PRO_0000294685.
SQ   SEQUENCE   1145 AA;  127582 MW;  2E4E696ABF9D18E4 CRC64;
     MAEIVASDEM NEYFNTLEGT LKKEIDIVND ARSRGKDPKP HVEIPLAKDL ADRVENLIGV
     KGVAELIRKL EETMSREEAA LALGREVAQG KVGEFDSKSE AIEAAIRVSV AMLTEGVVAA
     PIEGIDRASI GKNDDGSEYV SIFYAGPIRS AGGTAQALSV LVGDYVRRGV GIDRYKPRKE
     EVERYIEEIM LYKRVASLQY TPSEEEIRLI VENCPICIDG EPTEAEEVEG HRNLERIDTN
     RVRGGMALVL AEGLALKAPK IQKHVKNLKI DGWEWLEQLI SGVKSSSESD EDEETDGKPK
     IKPKDKYMRD LIAGRPVFSH PSRPGGFRLR YGRSRNTSFA AAGISPAGMI VMDDFIAPGT
     QLKVERPGKA AGMAPVDSIE GPTVRLNNGD VIRIDTIDEA YALRSEVEEI IDIGEILINY
     GDFLENNHPL APSPYCFEWW IQEYRKAAPD TETNEAELKE PTQEVALDLC KELNIPLHPK
     FTYLWHDIDN SQYTALADLI SKDGLLEADG SFLKLPLQRT IDTGMKKVLE DLLVQHKIQG
     QALTIEEPLP LIHSLGLDEE LSKGWDSLGH EELLENINEI AGFVVRPRAP TRIGARMGRP
     EKSDKRKMTP APHALFPIAE AGGNTRSLEK AANFKVNTNS KAGTIPVEIG NRICPACGVE
     GFEFRCECGE YTLPKLFCPR CGISVNKEKC PKCNSKTTCT SMRKIDFKSI YQKAFESIGE
     RDHLDSFKGV KKMMSKHMTP EPLEKGILRA KHGLFTFKDG TVRYDMSDIP LTHIRPAEIG
     VSCERMIELG YLKDIYGKPL IDSEQVLCLK VQDLVISYDA ADYILRITQY IDDLLVKYYK
     VAPYYNAKHI DDIVGVLLMG LAPHTSAGVL GRLIGFTTAS VGYAHPYFHA AKRRNCDGDE
     DCVMLLMDGL LNFSRDYLPD KRGGQMDAPL VLTTRLDPSE VDKEAHNIDM CASYPLEFYE
     ATQNIANPKD FEGTMDLVSG RLGTTLQYEE FMFTHDTSNI AAGPLKSAYK TLGTMVEKMD
     AQLELAKKIR AVDAPDVAER VLTSHFLPDM FGNLRAFSRQ RTRCVKCAAK FRRPPLTGSC
     PKCGGRVILT VHEGAVKKYL QVSIKIAEEY NVSSYTKQRI ELIGYDMKSL FENDKSKQMG
     LSDFM
//