Q12SR9FPG_SHEDOFormamidopyrimidine-DNA glycosylaseFapy-DNA glycosylase3.2.2.23DNA-(apurinic or apyrimidinic site) lyase MutMAP lyase MutM4.2.99.18mutMfpgSden_0210Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)BacteriaPseudomonadotaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanellaComplete sequence of Shewanella denitrificans OS217.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)Zn(2+)Binds 1 zinc ion per subunit.Monomer.Belongs to the FPG family.DNA damageDNA repairDNA-bindingGlycosidaseHydrolaseLyaseMetal-bindingMultifunctional enzymeReference proteomeZincZinc-fingerDNADNADNAMPELPEVEVTRQGIAPYLVDQTVVELIVRNASLRWPVPDLAHNIVGQTILSVRRRAKYLLIDTEAGITIVHLGMSGSLRILPRNTPVEKHDHIDLVLANGRMLRFNDPRRFGAWLWYELPEEAHPLLAKLGPEPLSEAFNPLQLLTALKGKKKAIKLCLMDNHIVVGVGNIYANEALFAAGIHPESEAGKIDIEKLTLLVVEVKQILAQAIKQGGTTLKDFTNADGKPGYFAQKLHVYGRGSKSCTHCGNLLSEIRLGQRTTVFCGLCQTK
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