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Q12SM7

- ASSY_SHEDO

UniProt

Q12SM7 - ASSY_SHEDO

Protein

Argininosuccinate synthase

Gene

argG

Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei96 – 961CitrullineUniRule annotation
    Binding sitei101 – 1011CitrullineUniRule annotation
    Binding sitei126 – 1261ATP; via amide nitrogenUniRule annotation
    Binding sitei128 – 1281AspartateUniRule annotation
    Binding sitei132 – 1321AspartateUniRule annotation
    Binding sitei132 – 1321CitrullineUniRule annotation
    Binding sitei133 – 1331AspartateUniRule annotation
    Binding sitei136 – 1361CitrullineUniRule annotation
    Binding sitei185 – 1851CitrullineUniRule annotation
    Binding sitei194 – 1941CitrullineUniRule annotation
    Binding sitei270 – 2701CitrullineUniRule annotation
    Binding sitei282 – 2821CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 249ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSDEN318161:GHKQ-266-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Sden_0253
    OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
    Taxonomic identifieri318161 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001982: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Argininosuccinate synthasePRO_0000263969Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi318161.Sden_0253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12SM7.
    SMRiQ12SM7. Positions 12-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiPWNEPTK.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12SM7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTVKKTGV KKVVLAYSGG LDTSAIIPWL KETYDDCEIV AFCADVGQGE    50
    EELVGLTEKA LASGASECHI VDLKEEFVKD YIYPTIATGA IYEGTYLLGT 100
    SMARPIIAKA QVEVARKVGA DALCHGCTGK GNDQVRFEGC FAALAPDLKV 150
    IAPWREWEMR SREDLLAYLA ARDIQTSASA TKIYSRDANA WHISHEGGEL 200
    EDPWNEPSKG VWTLTVAPED APDEAEYVAL SIKHGRVTHV NEQVLSPYNA 250
    LMKLNDIASK HGVGRIDITE NRLVGMKSRG CYETPGGTVM FAGLRAIEEL 300
    VLDKTSRTWR EQVAAQMAHL VYDGRWFTPL CNSLLAASES LAEAVNGDVV 350
    IKLYKGQATA VKKRSPNSLY SESFATFGED DVYDQKHAEG FIRLYSLASR 400
    IRAMNSN 407
    Length:407
    Mass (Da):44,615
    Last modified:August 22, 2006 - v1
    Checksum:i3E1A76B912BBFAE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000302 Genomic DNA. Translation: ABE53549.1.
    RefSeqiYP_561272.1. NC_007954.1.

    Genome annotation databases

    EnsemblBacteriaiABE53549; ABE53549; Sden_0253.
    GeneIDi4020364.
    KEGGisdn:Sden_0253.
    PATRICi23486114. VBISheDen79529_0273.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000302 Genomic DNA. Translation: ABE53549.1 .
    RefSeqi YP_561272.1. NC_007954.1.

    3D structure databases

    ProteinModelPortali Q12SM7.
    SMRi Q12SM7. Positions 12-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318161.Sden_0253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE53549 ; ABE53549 ; Sden_0253 .
    GeneIDi 4020364.
    KEGGi sdn:Sden_0253.
    PATRICi 23486114. VBISheDen79529_0273.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi PWNEPTK.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci SDEN318161:GHKQ-266-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS217 / ATCC BAA-1090 / DSM 15013.

    Entry informationi

    Entry nameiASSY_SHEDO
    AccessioniPrimary (citable) accession number: Q12SM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3