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Q12R39

- SYL_SHEDO

UniProt

Q12R39 - SYL_SHEDO

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Protein

Leucine--tRNA ligase

Gene
leuS, Sden_0797
Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEN318161:GHKQ-822-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Sden_0797
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001982: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligaseUniRule annotationPRO_0000334816Add
BLAST

Proteomic databases

PRIDEiQ12R39.

Interactioni

Protein-protein interaction databases

STRINGi318161.Sden_0797.

Structurei

3D structure databases

ProteinModelPortaliQ12R39.
SMRiQ12R39. Positions 228-416.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi622 – 6265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12R39-1 [UniParc]FASTAAdd to Basket

« Hide

MQELYNPSEI EALVQKHWQE HKTFEVTEDE SKEKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA INNKTSPAPW 100
TYENIDYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGMVY 150
KKTSSVNWCP NDETVLANEQ VQDGCCWRCD TPVIQKEIPQ WFIKITDYAE 200
ELLNDIDTLD GWPEQVKAMQ RNWIGRSEGI EMTFKVKDSE QSFDIYTTRP 250
DTLMGVTYVA IAAGHPLAEQ AASTNPALAA FIEECKNADT TEAAMASMEK 300
KGVATGLEAV HPISGKLVPI WVANFVLMNY GTGAVMSVPA HDQRDYEFAK 350
AYGLEMQAVI KPADSEVDIS KEAYTEKGVL FNSGTAFPEL DGLEFQAAFD 400
AIDARLTAEG KGKRQVNYRL RDWGVSRQRY WGAPIPMVTL ADGTVMPTPE 450
DQLPVILPED VVMDGIQSPI KADKAWAETT VDGKPAFRET DTFDTFMESS 500
WYYARYCSPH ADEMLDPAKA NYWLPVDQYI GGIEHACMHL LYFRFFHKLL 550
RDAGLVNSNE PAKRLLTQGM VLADAYYYTN DKGARVWVSP LEAEVVEKDD 600
KGRVVKAVDS QGNELVYTGM SKMSKSKNNG IDPQTMVEKY GADTVRLFMM 650
FASPPELTLE WQESGVEGAH RFIKRLWKLA SDHVAAGPTE ALDVSKLSSS 700
QKALRRELHK TIAKVSDDIG RRQMFNTAVA AVMELMNHLS KAPQDSAQDR 750
ALLAEALSAV TRLLYPIIPH MSFTLWHELG NSNNIEDSRW PDVDEAALVE 800
DSKLIVVQVN GKVRAKITVA ADATKEAVEQ LGLDDEHVQK HLEGLTVRKV 850
IYVPGKLLSL VAN 863
Length:863
Mass (Da):97,238
Last modified:May 20, 2008 - v2
Checksum:i76F3AB92441C7F9A
GO

Sequence cautioni

The sequence ABE54087.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE54087.1. Different initiation.
RefSeqiYP_561810.1. NC_007954.1.

Genome annotation databases

EnsemblBacteriaiABE54087; ABE54087; Sden_0797.
GeneIDi4016961.
KEGGisdn:Sden_0797.
PATRICi23487282. VBISheDen79529_0848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE54087.1 . Different initiation.
RefSeqi YP_561810.1. NC_007954.1.

3D structure databases

ProteinModelPortali Q12R39.
SMRi Q12R39. Positions 228-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318161.Sden_0797.

Proteomic databases

PRIDEi Q12R39.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE54087 ; ABE54087 ; Sden_0797 .
GeneIDi 4016961.
KEGGi sdn:Sden_0797.
PATRICi 23487282. VBISheDen79529_0848.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SDEN318161:GHKQ-822-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Entry informationi

Entry nameiSYL_SHEDO
AccessioniPrimary (citable) accession number: Q12R39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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