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Q12R39

- SYL_SHEDO

UniProt

Q12R39 - SYL_SHEDO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSDEN318161:GHKQ-822-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Sden_0797
    OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
    Taxonomic identifieri318161 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001982: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Leucine--tRNA ligasePRO_0000334816Add
    BLAST

    Proteomic databases

    PRIDEiQ12R39.

    Interactioni

    Protein-protein interaction databases

    STRINGi318161.Sden_0797.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12R39.
    SMRiQ12R39. Positions 228-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12R39-1 [UniParc]FASTAAdd to Basket

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    MQELYNPSEI EALVQKHWQE HKTFEVTEDE SKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA INNKTSPAPW 100
    TYENIDYMKN QLKLLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGMVY 150
    KKTSSVNWCP NDETVLANEQ VQDGCCWRCD TPVIQKEIPQ WFIKITDYAE 200
    ELLNDIDTLD GWPEQVKAMQ RNWIGRSEGI EMTFKVKDSE QSFDIYTTRP 250
    DTLMGVTYVA IAAGHPLAEQ AASTNPALAA FIEECKNADT TEAAMASMEK 300
    KGVATGLEAV HPISGKLVPI WVANFVLMNY GTGAVMSVPA HDQRDYEFAK 350
    AYGLEMQAVI KPADSEVDIS KEAYTEKGVL FNSGTAFPEL DGLEFQAAFD 400
    AIDARLTAEG KGKRQVNYRL RDWGVSRQRY WGAPIPMVTL ADGTVMPTPE 450
    DQLPVILPED VVMDGIQSPI KADKAWAETT VDGKPAFRET DTFDTFMESS 500
    WYYARYCSPH ADEMLDPAKA NYWLPVDQYI GGIEHACMHL LYFRFFHKLL 550
    RDAGLVNSNE PAKRLLTQGM VLADAYYYTN DKGARVWVSP LEAEVVEKDD 600
    KGRVVKAVDS QGNELVYTGM SKMSKSKNNG IDPQTMVEKY GADTVRLFMM 650
    FASPPELTLE WQESGVEGAH RFIKRLWKLA SDHVAAGPTE ALDVSKLSSS 700
    QKALRRELHK TIAKVSDDIG RRQMFNTAVA AVMELMNHLS KAPQDSAQDR 750
    ALLAEALSAV TRLLYPIIPH MSFTLWHELG NSNNIEDSRW PDVDEAALVE 800
    DSKLIVVQVN GKVRAKITVA ADATKEAVEQ LGLDDEHVQK HLEGLTVRKV 850
    IYVPGKLLSL VAN 863
    Length:863
    Mass (Da):97,238
    Last modified:May 20, 2008 - v2
    Checksum:i76F3AB92441C7F9A
    GO

    Sequence cautioni

    The sequence ABE54087.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000302 Genomic DNA. Translation: ABE54087.1. Different initiation.
    RefSeqiYP_561810.1. NC_007954.1.

    Genome annotation databases

    EnsemblBacteriaiABE54087; ABE54087; Sden_0797.
    GeneIDi4016961.
    KEGGisdn:Sden_0797.
    PATRICi23487282. VBISheDen79529_0848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000302 Genomic DNA. Translation: ABE54087.1 . Different initiation.
    RefSeqi YP_561810.1. NC_007954.1.

    3D structure databases

    ProteinModelPortali Q12R39.
    SMRi Q12R39. Positions 228-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318161.Sden_0797.

    Proteomic databases

    PRIDEi Q12R39.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE54087 ; ABE54087 ; Sden_0797 .
    GeneIDi 4016961.
    KEGGi sdn:Sden_0797.
    PATRICi 23487282. VBISheDen79529_0848.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SDEN318161:GHKQ-822-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS217 / ATCC BAA-1090 / DSM 15013.

    Entry informationi

    Entry nameiSYL_SHEDO
    AccessioniPrimary (citable) accession number: Q12R39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3