Q12QM6 (CYSC_SHEDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylyl-sulfate kinase
EC=2.7.1.25

Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase

Gene names

Name:	cysC
Ordered Locus Names:	Sden_0962

Organism

Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP]

Taxonomic identifier

318161 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylylsulfate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000009024
Regions
	Nucleotide binding	31 – 38	8	ATP By similarity
Sites
	Active site	105	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12QM6 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: E6747D86B6E245EE	FASTA	205	22,214
	10 20 30 40 50 60 MTDIVWHQHS IDQAARGAQK SQNPVLLWFT GLSGAGKSTL AGALERALFD AGFHTYLLDG 70 80 90 100 110 120 DNVRHGLCKD LGFSLSDRDE NLRRVGEVAK LMVDAGLVVL SAFISPTRAE RDRVRALFPE 130 140 150 160 170 180 GRFIEVHVST PLSVCEARDP KGLYVKARSG EIKEFTGISS PYEAPTAAEL TIDTSRGDLA 190 200 TQVQAMLAYL TAIEVIDANK LSALA

References

[1]

"Complete sequence of Shewanella denitrificans OS217." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000302 Genomic DNA. Translation: ABE54250.1.
RefSeq	YP_561973.1. NC_007954.1.
3D structure databases
ProteinModelPortal	Q12QM6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12QM6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4016564.
GenomeReviews	Gene locus Sden_0962 in contig CP000302_GR.
KEGG	sdn:Sden_0962.
NMPDR	fig|318161.14.peg.945.
PATRIC	23487644. VBISheDen79529_1022.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0529.
HOGENOM	HBG309946.
OMA	IVWHQHS.
PhylomeDB	Q12QM6.
ProtClustDB	PRK03846.
Enzyme and pathway databases
BioCyc	SDEN318161:SDEN_0962-MONOMER.
Family and domain databases
HAMAP	MF_00065. Adenylyl_sulf_kinase. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
KO	K00860.
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00455. ApsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_SHEDO

Accession

Primary (citable) accession number: Q12QM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program