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Q12QM6 (CYSC_SHEDO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenylyl-sulfate kinase

EC=2.7.1.25
Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase
Gene names
Name:cysC
Ordered Locus Names:Sden_0962
OrganismShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP]
Taxonomic identifier318161 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of activated sulfate. HAMAP MF_00065

Catalytic activity

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065

Sequence similarities

Belongs to the APS kinase family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processsulfate assimilation

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylylsulfate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Adenylyl-sulfate kinase HAMAP MF_00065
PRO_1000009024

Regions

Nucleotide binding31 – 388ATP By similarity

Sites

Active site1051Phosphoserine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12QM6 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: E6747D86B6E245EE

FASTA20522,214
        10         20         30         40         50         60 
MTDIVWHQHS IDQAARGAQK SQNPVLLWFT GLSGAGKSTL AGALERALFD AGFHTYLLDG 

        70         80         90        100        110        120 
DNVRHGLCKD LGFSLSDRDE NLRRVGEVAK LMVDAGLVVL SAFISPTRAE RDRVRALFPE 

       130        140        150        160        170        180 
GRFIEVHVST PLSVCEARDP KGLYVKARSG EIKEFTGISS PYEAPTAAEL TIDTSRGDLA 

       190        200 
TQVQAMLAYL TAIEVIDANK LSALA 

« Hide

References

[1]"Complete sequence of Shewanella denitrificans OS217."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000302 Genomic DNA. Translation: ABE54250.1.
RefSeqYP_561973.1. NC_007954.1.

3D structure databases

ProteinModelPortalQ12QM6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12QM6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4016564.
GenomeReviewsGene locus Sden_0962 in contig CP000302_GR.
KEGGsdn:Sden_0962.
NMPDRfig|318161.14.peg.945.
PATRIC23487644. VBISheDen79529_1022.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0529.
HOGENOMHBG309946.
OMAIVWHQHS.
PhylomeDBQ12QM6.
ProtClustDBPRK03846.

Enzyme and pathway databases

BioCycSDEN318161:SDEN_0962-MONOMER.

Family and domain databases

HAMAPMF_00065. Adenylyl_sulf_kinase.
[Tree]
InterProIPR002891. APS_kinase_C.
[Graphical view]
KOK00860.
PfamPF01583. APS_kinase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00455. ApsK. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCYSC_SHEDO
AccessionPrimary (citable) accession number: Q12QM6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families