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Reviewed, UniProtKB/Swiss-Prot Q12QD2 (ASTD1_SHEDO)

Last modified February 9, 2010. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase 1
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase 1
      Short name=SGSD 1
Gene names
Name: astD1
Ordered Locus Names: Sden_1056
OrganismShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP]
Taxonomic identifier318161 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process to glutamate

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498N-succinylglutamate 5-semialdehyde dehydrogenase 1 HAMAP MF_01174
PRO_0000262423

Regions

Nucleotide binding231 – 2366NAD By similarity

Sites

Active site2541 By similarity
Active site2881 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12QD2-1 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: C82E1ABF63CFB1C6

FASTA49852,396
        10         20         30         40         50         60 
MNQLEQLTPL TQTQFIAGQW LAGKGPSFSS VNPANGEVIW QGLGADAGQV DAAITSARAA 

        70         80         90        100        110        120 
FYTWSAMSLT ERLVIVEAFA EQLKEHAELF ARTIALETGK ALWESRTEVG AMTGKIAISI 

       130        140        150        160        170        180 
KANAERTGTV ENPMPGAKAF IRHKPHGVVA VFGPYNFPGH LPNGHIVPAL IAGNTVLFKP 

       190        200        210        220        230        240 
SELTPKVAEL TMQLWQQAGL PNGVLNLLQG EIATGKALAS HKGIDGLFFT GSSNTGHLLH 

       250        260        270        280        290        300 
QQYAGQPGKI LALEMGGNNP LIITEVANVD AAVHDIIQSA FISSGQRCTC ARRLFIPKTA 

       310        320        330        340        350        360 
NGDAILAKLL TSTAKIALGD PFAETQPFFG AMISDKAAAG MVKAQADIQA AGGVSLIELT 

       370        380        390        400        410        420 
QVTPGLGFVT PGIIDVTDAS PLADEEHFGP LLKVYRYTDF DAAIDEANNT SFGLSAGLLA 

       430        440        450        460        470        480 
DSETDYQHFY RRIRAGIVNW NKPITGASSA APFGGIGASG NHRASAYYAA DYCAYPVSSV 

       490 
EAQAVSLPAS LSPGLVIE 

« Hide

References

[1]"Complete sequence of Shewanella denitrificans OS217."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000302 Genomic DNA. Translation: ABE54344.1.
RefSeqYP_562067.1.

3D structure databases

SMRQ12QD2. Positions 13-442.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12QD2.

Genome annotation databases

GeneID4017563.
GenomeReviewsGene locus Sden_1056 in contig CP000302_GR.
KEGGsdn:Sden_1056.
NMPDRfig|318161.14.peg.1038.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAGTVENPM.
PhylomeDBQ12QD2.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03240. arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD1_SHEDO
AccessionPrimary (citable) accession number: Q12QD2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 22, 2006
Last modified: February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents