Reviewed, UniProtKB/Swiss-Prot Q12QD2 (ASTD1_SHEDO)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase 1
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase 1
      Short name=SGSD 1

Gene names

Name:	astD1
Ordered Locus Names:	Sden_1056

Organism

Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP]

Taxonomic identifier

318161 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	N-succinylglutamate 5-semialdehyde dehydrogenase 1 HAMAP MF_01174		PRO_0000262423
Regions
	Nucleotide binding	231 – 236	6	NAD By similarity
Sites
	Active site	254	1	By similarity
	Active site	288	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12QD2-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: C82E1ABF63CFB1C6	FASTA	498	52,396
	10 20 30 40 50 60 MNQLEQLTPL TQTQFIAGQW LAGKGPSFSS VNPANGEVIW QGLGADAGQV DAAITSARAA 70 80 90 100 110 120 FYTWSAMSLT ERLVIVEAFA EQLKEHAELF ARTIALETGK ALWESRTEVG AMTGKIAISI 130 140 150 160 170 180 KANAERTGTV ENPMPGAKAF IRHKPHGVVA VFGPYNFPGH LPNGHIVPAL IAGNTVLFKP 190 200 210 220 230 240 SELTPKVAEL TMQLWQQAGL PNGVLNLLQG EIATGKALAS HKGIDGLFFT GSSNTGHLLH 250 260 270 280 290 300 QQYAGQPGKI LALEMGGNNP LIITEVANVD AAVHDIIQSA FISSGQRCTC ARRLFIPKTA 310 320 330 340 350 360 NGDAILAKLL TSTAKIALGD PFAETQPFFG AMISDKAAAG MVKAQADIQA AGGVSLIELT 370 380 390 400 410 420 QVTPGLGFVT PGIIDVTDAS PLADEEHFGP LLKVYRYTDF DAAIDEANNT SFGLSAGLLA 430 440 450 460 470 480 DSETDYQHFY RRIRAGIVNW NKPITGASSA APFGGIGASG NHRASAYYAA DYCAYPVSSV 490 EAQAVSLPAS LSPGLVIE

References

[1]

"Complete sequence of Shewanella denitrificans OS217." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000302 Genomic DNA. Translation: ABE54344.1.
RefSeq	YP_562067.1.
3D structure databases
SMR	Q12QD2. Positions 13-442.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12QD2.
Genome annotation databases
GeneID	4017563.
GenomeReviews	Gene locus Sden_1056 in contig CP000302_GR.
KEGG	sdn:Sden_1056.
NMPDR	fig|318161.14.peg.1038.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	GTVENPM.
PhylomeDB	Q12QD2.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD1_SHEDO

Accession

Primary (citable) accession number: Q12QD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	August 22, 2006
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)