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Protein

Catalase-peroxidase

Gene

katG

Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei91Transition state stabilizerUniRule annotation1
Active sitei95Proton acceptorUniRule annotation1
Metal bindingi263Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSDEN318161:G1G6C-1471-MONOMER

Protein family/group databases

PeroxiBasei2713 SdeCP01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Sden_1384
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001982 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_000035491722 – 720Catalase-peroxidaseAdd BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki94 ↔ 222Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-248)UniRule annotation
Cross-linki222 ↔ 248Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-94)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ12PF6

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi318161.Sden_1384

Structurei

3D structure databases

ProteinModelPortaliQ12PF6
SMRiQ12PF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiCPVVHTH
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12PF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENKCPVMH GSATTTENSM ANMNWWPKSL SLDILHQHDH KTNPMAADFN
60 70 80 90 100
YQDEVKKLDF VALKNDLHAL MTDSQAWWPA DWGHYGGLMI RLTWHAAGTY
110 120 130 140 150
RIADGRGGAG HGSQRFAPLN SWPDNGNLDK ARRLLWPIKK KYGNKLSWAD
160 170 180 190 200
LIAYAGTIAY ESMGLKTFGF AFGREDIWHP EKDIYWGAEK DWLLPTDNDN
210 220 230 240 250
SRYSGERNLE NPLAAVMMGL IYVNPEGVDG KPDPLKTAQD IRETFARMAM
260 270 280 290 300
NDEETVALTA GGHTVGKAHG NGNADLLGPE PEDADIHDQG FGWLNKAKRG
310 320 330 340 350
IGRDTVTSGI EGAWTTHPTQ WDNGYFTMLL NHEWELCKSP AGAWQWQPIN
360 370 380 390 400
IKEEDKPRDV EDPSISTMPM MTDADMAMKM DPEYRKISEH FHRDPEYFSK
410 420 430 440 450
VFSRAWFKLT HRDMGPKVRY LGPDVPVEDL LWQDPVPTGP KDFNVAVVKK
460 470 480 490 500
AIKETGLSIS DMVTTAWDSA RTFRGSDKRG GANGARIRLA LQKQWAGNEP
510 520 530 540 550
KRLASVLSVL EPIAASHGVS VADVIVLAGN LGIELAAKKA GFDVTVPFIS
560 570 580 590 600
GRGDATDEMT DNESFAVLEP LHDGYRNWLK QDFAVSAEEL MLDRTQLMGL
610 620 630 640 650
TAHEMTVLVG GMRVIGTNYA ETGHGVFTER KGALTNDFFV NLTDMNYIWK
660 670 680 690 700
PIGQNEYEIC ERETGKRKWT ASRVDLIFGS NSVLRSYAEV YAQDDNKQKF
710 720
VNDFISAWTK MMNADRFDVS
Length:720
Mass (Da):80,755
Last modified:August 22, 2006 - v1
Checksum:i776975A1B1174F09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000302 Genomic DNA Translation: ABE54670.1
RefSeqiWP_011495828.1, NC_007954.1

Genome annotation databases

EnsemblBacteriaiABE54670; ABE54670; Sden_1384
KEGGisdn:Sden_1384

Similar proteinsi

Entry informationi

Entry nameiKATG_SHEDO
AccessioniPrimary (citable) accession number: Q12PF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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