Q12NX5 (Q12NX5_SHEDO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387
Short name=UDP-N-acetylglucosamine acyltransferase HAMAP MF_00387
EC=2.3.1.129 HAMAP MF_00387

Gene names

Name:	lpxA HAMAP MF_00387
Ordered Locus Names:	Sden_1566

Organism

Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP] EMBL ABE54851.1

Taxonomic identifier

318161 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP MF_00387

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00387 Lipid synthesis
Cellular component	Cytoplasm HAMAP MF_00387
Domain	Repeat HAMAP MF_00387
Molecular function	Acyltransferase HAMAP MF_00387 EMBL ABE54851.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q12NX5 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: A9A5799B4BAA530D	FASTA	256	27,566
	10 20 30 40 50 60 MIDKLAFVHP EAKIGNNVTI GPWTYIGAGV EIGDDTWISS HVVVKGPSVI GKGNKIFQFA 70 80 90 100 110 120 SVGEDCQDKK YAGEPTRLVM GDNNIIRESV TIHRGTVQDN SETRIGSNNL FMAYVHIAHD 130 140 150 160 170 180 CVVGNNVIMA NNASIAGHVH VGDWVILGGM TGVHQFVHIG AHAFAAGSSL ILQDVPPFVM 190 200 210 220 230 240 ASGQPAIPRG LNAEGLKRRG FSKESQLAVR RAYKTLYRQG LTVAEALDVL QGEAEKDEHV 250 KSLVDFVSSS SRGIIR

References

[1]

"Complete sequence of Shewanella denitrificans OS217." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000302 Genomic DNA. Translation: ABE54851.1.
RefSeq	YP_562574.1. NC_007954.1.
3D structure databases
ProteinModelPortal	Q12NX5.
SMR	Q12NX5. Positions 2-256.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12NX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4018040.
GenomeReviews	Gene locus Sden_1566 in contig CP000302_GR.
KEGG	sdn:Sden_1566.
NMPDR	fig|318161.14.peg.1533.
PATRIC	23488978. VBISheDen79529_1666.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1043.
HOGENOM	HBG659295.
OMA	REFCTFN.
PhylomeDB	Q12NX5.
ProtClustDB	PRK05289.
Enzyme and pathway databases
BioCyc	SDEN318161:SDEN_1566-MONOMER.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 4 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q12NX5_SHEDO

Accession

Primary (citable) accession number: Q12NX5

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)