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Q12NA7

- ASTE_SHEDO

UniProt

Q12NA7 - ASTE_SHEDO

Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotation

    Catalytic activityi

    N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi67 – 671ZincUniRule annotation
    Metal bindingi70 – 701ZincUniRule annotation
    Metal bindingi164 – 1641ZincUniRule annotation
    Active sitei228 – 2281UniRule annotation

    GO - Molecular functioni

    1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
    2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
    2. arginine catabolic process to succinate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSDEN318161:GHKQ-1848-MONOMER.
    UniPathwayiUPA00185; UER00283.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
    Gene namesi
    Name:astEUniRule annotation
    Ordered Locus Names:Sden_1785
    OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
    Taxonomic identifieri318161 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001982: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Succinylglutamate desuccinylasePRO_0000262080Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi318161.Sden_1785.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12NA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2988.
    HOGENOMiHOG000280300.
    KOiK05526.
    OMAiTAPIEIC.
    OrthoDBiEOG613070.

    Family and domain databases

    HAMAPiMF_00767. Arg_catab_AstE.
    InterProiIPR007036. Aste_AspA.
    IPR016681. SuccinylGlu_desuccinylase.
    [Graphical view]
    PfamiPF04952. AstE_AspA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017020. AstE. 1 hit.
    TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q12NA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQHELMDNHD FLAFTLAHPH GIAQRFSFEL GQHTQVEVWD TGVIAFLPKE    50
    KYTAQAPKQV ILSCAVHGNE TAPIEICNRL ITELLTEKVQ AKHRTLFLIG 100
    NPPAIHNQTR FIEENMNRLF SGAHSKGEGL THAERIRAKA LEDYVAEFYL 150
    GAPSNEQRIH YDLHTAIRPS KHEKFAIYPY RPGRAYSGEQ IMFLAACGVD 200
    TILFHHEPTT TFSYYSSEQF NADAFTVELG KVMPFGQNDM SRFEQTQTML 250
    TKLVSGEALG LSAFSAEKVN LYKVCRSINK RFEDFAFNFA DQAENFSAFT 300
    KGEVLATEGG EQVLVEQPQE AIVFPNAKVP VGQRTVLCLV PAPNENIR 348
    Length:348
    Mass (Da):39,197
    Last modified:August 22, 2006 - v1
    Checksum:i3B18928CD9F64240
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000302 Genomic DNA. Translation: ABE55069.1.
    RefSeqiWP_011496226.1. NC_007954.1.
    YP_562792.1. NC_007954.1.

    Genome annotation databases

    EnsemblBacteriaiABE55069; ABE55069; Sden_1785.
    GeneIDi4018264.
    KEGGisdn:Sden_1785.
    PATRICi23489447. VBISheDen79529_1896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000302 Genomic DNA. Translation: ABE55069.1 .
    RefSeqi WP_011496226.1. NC_007954.1.
    YP_562792.1. NC_007954.1.

    3D structure databases

    ProteinModelPortali Q12NA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318161.Sden_1785.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE55069 ; ABE55069 ; Sden_1785 .
    GeneIDi 4018264.
    KEGGi sdn:Sden_1785.
    PATRICi 23489447. VBISheDen79529_1896.

    Phylogenomic databases

    eggNOGi COG2988.
    HOGENOMi HOG000280300.
    KOi K05526.
    OMAi TAPIEIC.
    OrthoDBi EOG613070.

    Enzyme and pathway databases

    UniPathwayi UPA00185 ; UER00283 .
    BioCyci SDEN318161:GHKQ-1848-MONOMER.

    Family and domain databases

    HAMAPi MF_00767. Arg_catab_AstE.
    InterProi IPR007036. Aste_AspA.
    IPR016681. SuccinylGlu_desuccinylase.
    [Graphical view ]
    Pfami PF04952. AstE_AspA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017020. AstE. 1 hit.
    TIGRFAMsi TIGR03242. arg_catab_astE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS217 / ATCC BAA-1090 / DSM 15013.

    Entry informationi

    Entry nameiASTE_SHEDO
    AccessioniPrimary (citable) accession number: Q12NA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3